Výsledky vyhledávání - "Junko Mizukami"

Skeletal Muscle FOXO1 (FKHR) Transgenic Mice Have Less Skeletal Muscle Mass, Down-regulated Type I (Slow Twitch/Red Muscle) Fiber Genes, and Impaired Glycemic Control

Autor: Shinji Miura, Ichizo Nishino, Yuko Kai, Junko Mizukami, Tomoyasu Taniguchi, Yasutomi Kamei, Miki Suzuki, Tomoko Hata, Osamu Ezaki, Keiji Mochida, Hiroyuki Aburatani, Junichiro Matsuda

Publikováno v: Journal of Biological Chemistry. 279:41114-41123

FOXO1, a member of the FOXO forkhead type transcription factors, is markedly up-regulated in skeletal muscle in energy-deprived states such as fasting and severe diabetes, but its functions in skeletal muscle have remained poorly understood. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e38696aac00ae5456b9397d0eeda27d
https://doi.org/10.1074/jbc.m400674200

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A forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle

Autor: Miki Suzuki, Nobuyuki Takahashi, Yasutomi Kamei, Tomoyasu Taniguchi, Teruo Kawada, Osamu Ezaki, Shinji Miura, Junko Mizukami

Publikováno v: FEBS Letters. 536:232-236

Lipoprotein lipase (LPL) plays a role in lipid usage in skeletal muscle by hydrolyzing plasma triglycerides into fatty acids, which are further utilized for β-oxidation. Lipid usage is stimulated during fasting, diabetes mellitus and exercise, conco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bf71589154b4ada73d3e6957653435
https://doi.org/10.1016/s0014-5793(03)00062-0

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Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1

Autor: Hiroaki Sakurai, Hidetaka Miyoshi, Takahisa Sugita, Junko Mizukami

Publikováno v: FEBS Letters. 474:141-145

TAK1 is a mitogen-activated protein kinase kinase kinase (MAP3K) that is involved in the c-Jun N-terminal kinase/p38 MAPKs and NF-κB signaling pathways. Here, we characterized the molecular mechanisms of TAK1 activation by its specific activator TAB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8aae326124d7c3c0d013c86e061fdc
https://doi.org/10.1016/s0014-5793(00)01588-x

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The Antidiabetic Agent Thiazolidinedione Stimulates the Interaction between PPARγ and CBP

Autor: Tomoyasu Taniguchi, Junko Mizukami

Publikováno v: Biochemical and Biophysical Research Communications. 240:61-64

The peroxisome proliferator-activated receptor (PPAR) gamma is a member of the nuclear hormone receptor family, which is predominantly expressed on adipocytes and considered to be involved in the process of adipogenesis. The new thiazolidinedione (TZ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1adeb11ba28ff94f70a67aa718aad04b
https://doi.org/10.1006/bbrc.1997.7602

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TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways

Autor: Takahisa Sugita, Hidetaka Miyoshi, Hiroaki Sakurai, Akito Nishi, Naoya Sato, Junko Mizukami

Publikováno v: Biochemical and biophysical research communications. 297(5)

TAK1 mitogen-activated protein kinase kinase kinase (MAP3K) is activated by its specific activator, TAK1-binding protein 1 (TAB1). A constitutively active TAK1 mutant has not yet been generated due to the indispensable requirement of TAB1 for TAK1 ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95bc69fc37528e986aac92c7b1e62c7
https://pubmed.ncbi.nlm.nih.gov/12372426

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Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6

Autor: Giichi Takaesu, Hiroyuki Akatsuka, Naoki Sakurai, Hiroaki Sakurai, Kunihiro Matsumoto, Junko Mizukami, Jun Ninomiya-Tsuji

Publikováno v: Molecular and cellular biology. 22(4)

The receptor activator of NF-kappaB (RANK) and its ligand RANKL are key molecules for differentiation and activation of osteoclasts. RANKL stimulates transcription factors AP-1 through mitogen-activated protein kinase (MAPK) activation, and NF-kappaB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c27129aca4bafc03b5a3a13225740c
https://pubmed.ncbi.nlm.nih.gov/11809792

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The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha

Autor: Etsuro Sugimoto, Junko Mizukami, Teruo Kawada, Yasutomi Kamei

Publikováno v: Life sciences. 55(16)

Retinoids, especially all-trans retinoic acid (RA), have been shown to inhibit the differentiation of preadipose cells. It is important to human health, especially to obesity, that the regulatory system for the differentiation of adipocytes is well d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1fa4f29b2fa67ecdbc2e12fa6f8e19
https://pubmed.ncbi.nlm.nih.gov/7934625

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