Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Junko Kohara"'
Autor:
Tomohiro Okagawa, Satoru Konnai, Shinya Goto, Yamato Sajiki, Otgontuya Ganbaatar, Kei Watari, Hayato Nakamura, Cai-Xia Wang, Taro Tachibana, Yukinari Kato, Yayoi Kameda, Junko Kohara, Nobuhiro Terasaki, Manabu Kubota, Akira Takeda, Hirofumi Takahashi, Yasuhiko Suzuki, Naoya Maekawa, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
Veterinary Research, Vol 54, Iss 1, Pp 1-14 (2023)
Abstract Immune checkpoint molecules PD-1/PD-L1 cause T-cell exhaustion and contribute to disease progression in chronic infections of cattle. We established monoclonal antibodies (mAbs) that specifically inhibit the binding of bovine PD-1/PD-L1; how
Externí odkaz:
https://doaj.org/article/d1e0e81c1ed349c095a5bc6af2dd26e6
Autor:
Ayumi Nakatsuchi, Aronggaowa Bao, Sonoko Watanuki, Ryosuke Matsuura, Liushiqi Borjigin, Lanlan Bai, Maho Kuroda, Yasunobu Matsumoto, Junko Kohara, Yoko Aida
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
IntroductionBovine leukemia virus (BLV) belongs to the family Retroviridae and is a causative agent for enzootic bovine leucosis, the most common neoplastic disease affecting cattle worldwide. BLV proviral load (PVL) is associated with disease progre
Externí odkaz:
https://doaj.org/article/7a986a3eb9d341909525f6585d7944b3
Autor:
Yamato Sajiki, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Shinya Goto, Junko Kohara, Atsushi Nitanai, Hirofumi Takahashi, Kentaro Kubota, Hiroshi Takeda, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Immune suppression during pregnancy and parturition is considered a risk factor that is related to the progression of bovine chronic diseases, such as bovine leukosis, which is caused by bovine leukemia virus (BLV). Our previous studies have demonstr
Externí odkaz:
https://doaj.org/article/1fc529d9dc554e37891e8707f6dd9ce1
Publikováno v:
Pathogens, Vol 12, Iss 1, p 130 (2023)
Bovine leukemia virus (BLV) is the etiological agent of enzootic bovine leukosis. However, the propagation and distribution of BLV after primary infection still need to be fully elucidated. Here, we experimentally infected seven cattle with BLV and a
Externí odkaz:
https://doaj.org/article/63b84461d06943609a4d171c2e4d87a4
Autor:
Lanlan Bai, Shin-nosuke Takeshima, Masaaki Sato, William C. Davis, Satoshi Wada, Junko Kohara, Yoko Aida
Publikováno v:
Virology Journal, Vol 16, Iss 1, Pp 1-8 (2019)
Abstract Background Bovine leukemia virus (BLV), which is closely related to human T-cell leukemia virus, is the etiological agent of enzootic bovine leukosis, a disease characterized by a highly prolonged course involving persistent lymphocytosis an
Externí odkaz:
https://doaj.org/article/4c73345406584fb69e4f0a524fbd36b0
Autor:
Yamato Sajiki, Satoru Konnai, Shinya Goto, Tomohiro Okagawa, Kosuke Ohira, Honami Shimakura, Naoya Maekawa, Satoshi Gondaira, Hidetoshi Higuchi, Motoshi Tajima, Yuki Hirano, Junko Kohara, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2020)
Regulatory T cells (Tregs) regulate immune responses and maintain host immune homeostasis. Tregs contribute to the disease progression of several chronic infections by oversuppressing immune responses via the secretion of immunosuppressive cytokines,
Externí odkaz:
https://doaj.org/article/322f6ea3de6c4d969d146127ca9fc2e9
Autor:
Shinya Goto, Satoru Konnai, Yuki Hirano, Junko Kohara, Tomohiro Okagawa, Naoya Maekawa, Yamato Sajiki, Kei Watari, Erina Minato, Atsuhi Kobayashi, Satoshi Gondaira, Hidetoshi Higuchi, Masateru Koiwa, Motoshi Tajima, Eiji Taguchi, Ryoko Uemura, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, Keiichi Yamamoto, Mikihiro Toda, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2020)
Bovine mycoplasmosis caused by Mycoplasma bovis results in pneumonia and mastitis in cattle. We previously demonstrated that the programmed death 1 (PD-1)/PD-ligand 1 (PD-L1) pathway is involved in immune dysfunction during M. bovis infection and tha
Externí odkaz:
https://doaj.org/article/a6e71fa9104e4360be6bba148bb70726
Autor:
Tomohiro Okagawa, Satoru Konnai, Asami Nishimori, Naoya Maekawa, Shinya Goto, Ryoyo Ikebuchi, Junko Kohara, Yasuhiko Suzuki, Shinji Yamada, Yukinari Kato, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
Veterinary Research, Vol 49, Iss 1, Pp 1-12 (2018)
Abstract Bovine leukemia virus (BLV) is a retrovirus that infects B cells in cattle and causes bovine leukosis after a long latent period. Progressive exhaustion of T cell functions is considered to facilitate disease progression of BLV infection. Pr
Externí odkaz:
https://doaj.org/article/f4608a6016e34b98a040c72bdc125abb
Autor:
Tomohiro Okagawa, Satoru Konnai, Asami Nishimori, Naoya Maekawa, Ryoyo Ikebuchi, Shinya Goto, Chie Nakajima, Junko Kohara, Satoshi Ogasawara, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Blockade of immunoinhibitory molecules, such as programmed death-1 (PD-1)/PD-ligand 1 (PD-L1), is a promising strategy for reinvigorating exhausted T cells and preventing disease progression in a variety of chronic infections. Application of this the
Externí odkaz:
https://doaj.org/article/ece38efd907b407198c686f3f45704db
Autor:
Asami Nishimori, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Ryoyo Ikebuchi, Shinya Goto, Yamato Sajiki, Yasuhiko Suzuki, Junko Kohara, Satoshi Ogasawara, Yukinari Kato, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174916 (2017)
Programmed death-1 (PD-1), an immunoinhibitory receptor on T cells, is known to be involved in immune evasion through its binding to PD-ligand 1 (PD-L1) in many chronic diseases. We previously found that PD-L1 expression was upregulated in cattle inf
Externí odkaz:
https://doaj.org/article/014030c4e1884130b43fa0bb10f61216