Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Junko Kawawaki"'
Autor:
Yukiko, Yoshida, Makoto, Asahina, Arisa, Murakami, Junko, Kawawaki, Meari, Yoshida, Reiko, Fujinawa, Kazuhiro, Iwai, Ryuichi, Tozawa, Noriyuki, Matsuda, Keiji, Tanaka, Tadashi, Suzuki
Publikováno v:
Proc Natl Acad Sci U S A
Mutations in the human peptide:N-glycanase gene (NGLY1), which encodes a cytosolic de–N-glycosylating enzyme, cause a congenital autosomal recessive disorder. In rodents, the loss of Ngly1 results in severe developmental delay or lethality, but the
Autor:
Arisa Murakami, Tadashi Suzuki, Noriyuki Matsuda, Kazuhiro Iwai, Reiko Fujinawa, Yukiko Yoshida, Keiji Tanaka, Ryuichi Tozawa, Makoto Asahina, Meari Yoshida, Junko Kawawaki
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Significance Cytosolic peptide: N -glycanase (NGLY1) is a widely conserved enzyme involved in de– N -glycosylation of N -glycosylated proteins. Mutations in the human NGLY1 gene cause global developmental delay and multisystemic symptoms, but the m
Autor:
Yosuke Demizu, Ryota Hayashida, Waka Kojima, Fumika Koyano, Keiji Tanaka, Junko Kawawaki, Noriyuki Matsuda, Reika Kikuchi, Takuji Shoda, Koji Yamano, Mikihiko Naito
Publikováno v:
The Journal of Cell Biology
Damaged mitochondria are selectively eliminated by Parkin/PINK1-mediated autophagy. Kikuchi et al. show that in addition to binding ATG8 proteins, one of the critical autophagy adaptors, OPTN, possesses an ATG9A binding site that contributes to de no
Autor:
Sayaka Yasuda, Toshiharu Fujita, Keiji Tanaka, Yukiko Yoshida, Yasushi Saeki, Maho Hamasaki, Tamotsu Yoshimori, Arisa Murakami, Junko Kawawaki, Noriyuki Matsuda, Kazuhiro Iwai
Publikováno v:
Proceedings of the National Academy of Sciences. 114:8574-8579
Ubiquitination functions as a signal to recruit autophagic machinery to damaged organelles and induce their clearance. Here, we report the characterization of FBXO27, a glycoprotein-specific F-box protein that is part of the SCF (SKP1/CUL1/F-box prot
Autor:
Yukiko Yoshida, Makoto Asahina, Arisa Murakami, Junko Kawawaki, Meari Yoshida, Reiko Fujinawa, Kazuhiro Iwai, Ryuichi Tozawa, Noriyuki Matsuda, Keiji Tanaka, Tadashi Suzuki
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 7/6/2021, Vol. 118 Issue 27, p1-9, 9p
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 468:837-847
Acidification of the resorption pits, which is essential for dissolving bone, is produced by secretion of protons through vacuolar H(+)-ATPases in the plasma membrane of bone-resorbing cells, osteoclasts. Consequently, osteoclasts face highly acidic
Autor:
Tsunehiro Mizushima, Kenji Takagi, Junko Kawawaki, Mirai Tanigawa, Tatsuya Maeda, Yoko Kimura, Keiji Tanaka
Publikováno v:
Eukaryotic Cell. 14:976-982
Yeast Bro1 and Rim20 belong to a family of proteins which possess a common architecture of Bro1 and V domains. Alix and His domain protein tyrosine phosphatase (HD-PTP), mammalian Bro1 family proteins, bind YP(X) n L ( n = 1 to 3) motifs in their tar
Autor:
Yohei Ohnuma, Takahiro Takata, Kunihiko Yasuda, Junko Kawawaki, Yoko Kimura, Keiji Tanaka, Akira Kakizuka
Publikováno v:
FEBS Letters. 589:576-580
We identified a yeast mutant with temperature-sensitive growth defects that were rescued by VCP expression. The mutation occurred in GPI10, which encodes a mannosyl transferase for glycosylphosphatidylinositol anchor formation in the endoplasmic reti
Autor:
Yukiko, Yoshida, Sayaka, Yasuda, Toshiharu, Fujita, Maho, Hamasaki, Arisa, Murakami, Junko, Kawawaki, Kazuhiro, Iwai, Yasushi, Saeki, Tamotsu, Yoshimori, Noriyuki, Matsuda, Keiji, Tanaka
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(32)
Although lysosomes play a crucial role in autophagy, damaged lysosomes are eliminated by autophagy. The molecular mechanisms that recognize lysosomal damage in cells remain poorly understood, but ubiquitination is a known prerequisite for directing a
Autor:
Seiji Hori, Akira Kakizuka, Kei Okatsu, Junko Kawawaki, Yukie Kakiyama, Noriyuki Matsuda, Junpei Fukushi, Yoko Kimura, Keiji Tanaka
Publikováno v:
Genes to Cells. 18:1131-1143
VCP/p97 is a hexameric ring-shaped AAA(+) ATPase that participates in various ubiquitin-associated cellular functions. Mis-sense mutations in VCP gene are associated with the pathogenesis of two inherited diseases: inclusion body myopathy associated