Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Junko Horiguchi-Yamada"'
Autor:
Nobuakira Takeda, Tetsuaki Sekikawa, Junko Horiguchi-Yamada, Shinobu Takahara, Hisashi Yamada, Hideaki Suzuki
Publikováno v:
European Journal of Haematology. 78:264-269
Richter's syndrome occurs in 5-10% of patients with chronic lymphocytic leukemia, either by transformation of the primary neoplastic lymphocyte, or as a distinct B-cell neoplasm. We report a Japanese patient with lymphoplasmacytic lymphoma in whom a
Autor:
Miyuki Agawa, Shinobu Saito, Yasuhiko Kano, Hisashi Yamada, Junko Horiguchi-Yamada, Yasuhiro Arakawa
Publikováno v:
Leukemia Research. 30:723-734
Depsipeptide (FK228), a histone deacetylase inhibitor, is a promising new anticancer agent. The mechanism of resistance to this agent was studied using KU812 cells. Depsipeptide-resistant KU812 cells expressed P-glycoprotein (P-gp) and their resistan
Autor:
Satsuki Iwase, Yusuke Furukawa, Hisashi Yamada, Shinobu Saito, Takeshi Kawano, Yasuhiko Kano, Junko Horiguchi-Yamada
Publikováno v:
Leukemia Research. 28:623-629
Bcr-Abl tyrosine kinase inhibitor induces apoptosis and erythroid differentiation of K562 cells. During this erythroid differentiation, c-Myc and cyclin D1 transcripts are transiently downregulated. Accordingly, we studied the effect of cyclin D1 ove
Autor:
Takeshi Kawano, Satsuki Iwase, Yasuhiko Kano, Yusuke Furukawa, Junko Horiguchi-Yamada, Hisashi Yamada
Publikováno v:
Molecular and Cellular Biochemistry. 258:25-33
K562 cells contain a Bcr-Abl chimeric gene and differentiate into various lineages in response to different inducers. We studied the role of the mitogen-activated protein kinase (MAPK) kinase 1 (MEK1)/extracellular signal-regulated kinase (ERK) pathw
Autor:
Tetsuaki Sekikawa, Shuji Nakada, Satsuki Iwase, Kiyoshi Ito, Masayuki Kobayashi, Shinobu Takahara, Takeshi Kawano, Hisashi Yamada, Junko Horiguchi-Yamada
Publikováno v:
International Journal of Hematology. 76:453-459
B-cell diseases are classified on the basis of the normal differentiation stages. We report here a case of a patient with a long history of leukocytosis, splenomegaly without lymphadenopathy, and hyperviscosity symptoms. Clinically, the patient's dia
Autor:
Makoto Nagai, Sachiko Fukumi, Shuji Nakada, Tsuneya Ohno, Junko Horiguchi-Yamada, Hisashi Yamada
Publikováno v:
Molecular and Cellular Biochemistry. 206:43-50
Etoposide is a potent anticancer agent that is used to treat various tumors. We have investigated the dose-dependent effect of etoposide on apoptosis using chronic myeloid leukemia K562 cells treated with low (5 μM) or high (100 μM) concentrations
Autor:
Hisashi Yamada, Hideaki Mizoguchi, Yasutaka Hoshi, Masaharu Akiyama, Shinobu Saito, O Yamada, Junko Horiguchi-Yamada
Publikováno v:
European Journal of Cancer. 35:309-315
Telomerase, the enzyme that maintains the ends of linear eukaryotic chromosomes, is more active in the majority of malignant tumours than in normal somatic cells. Telomerase plays a key role in the maintenance of chromosomal stability in tumours, but
Autor:
Satsuki Iwase, Mayumi Takao, Hiroshi Ideguchi, Tetsuaki Sekikawa, Shinobu Takahara, Hisashi Yamada, Masafumi Iwasaki, Seibu Mochizuki, Junko Horiguchi-Yamada
Publikováno v:
Acta Haematologica. 100:200-203
We report a case of spherocytosis associated with erythrocyte band 3 deficiency. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of erythrocyte membrane proteins showed that the patient’s band 3 was reduced to about 80% of the control lev
Autor:
Makoto Nagai, Shinobu Takahara, Junko Horiguchi-Yamada, Satsuki Iwase, Tetsuaki Sekikawa, Takeshi Kawano, Hisashi Yamada, Sachiko Fukumi, Kiyoshi Itoh
Publikováno v:
Molecular and Cellular Biochemistry. 187:211-220
Therapeutic strategies for leukemia are directed to induction of differentiation and apoptosis as well as growth inhibition. One of the key antileukemic agents, 1-β-D-arabinofuranosylcytosine (ara C), is clinically applied according to these therape
Autor:
Satsuki Iwase, Osamu Yamada, Shinobu Saito, Yusuke Furukawa, Junko Horiguchi-Yamada, Tsuneya Ohno, Hisashi Yamada, Hideaki Mizoguchi, Masaharu Akiyama
Publikováno v:
Cancer Letters. 380:611