Výsledky vyhledávání - "Junko Fukumura"

Polygenic architecture informs potential vulnerability to drug-induced liver injury

Autor: Paola Nicoletti, Hisashi Anayama, Yasunori Nio, Yui Noguchi, Paul B. Watkins, Takanori Takebe, Momoko Ohori, Eri Kawakami, Guruprasad P. Aithal, Masaru Koido, Tadahiro Shinozawa, Junko Fukumura, Ann K. Daly, Yvonne P. Dragan

Publikováno v: Nat Med

Drug-induced liver injury (DILI) is a leading cause of termination in drug development programs and removal of drugs from the market; this is partially due to the inability to identify patients who are at risk1. In this study, we developed a polygeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e2931a5dda5b2e2f7d2b4a5e3b0f9a
https://europepmc.org/articles/PMC8482794/

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Impact of bevacizumab in combination with erlotinib onEGFR-mutated non-small cell lung cancer xenograft models with T790M mutation orMETamplification

Autor: Junko Fukumura, Naoki Harada, Koh Furugaki, Kaname Yamamoto, Mitsue Kurasawa, Keigo Yorozu, Mieko Yanagisawa, Kenichi Suda, Yoichiro Moriya, Toshiki Iwai, Tetsuya Mitsudomi, Hiroshi Mizuuchi

Publikováno v: International Journal of Cancer. 138:1024-1032

Erlotinib (ERL), an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, shows notable efficacy against non-small cell lung cancer (NSCLC) harboring EGFR mutations. Bevacizumab (BEV), a humanized monoclonal antibody to vascular endothel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a39bec3135f564465aa0da5ac02d0da7
https://doi.org/10.1002/ijc.29848

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1α,25(OH)2D3 downregulates gene expression levels of muscle ubiquitin ligases MAFbx and MuRF1 in human myotubes

Autor: Naohiko Hayakawa, Hideyuki Yasuno, Junko Fukumura, Hidemitsu Kitamura, Kaori Fujimoto-Ouchi

Publikováno v: Biomedical Research. 36:71-80

Clinical trials involving in patients with osteoporosis have reported that activated vitamin D3 (1α,25(OH)2D3, calcitriol) can prevent falling by acting on the skeletal muscles. However, pharmacological mechanisms of 1α,25(OH)2D3 with respect to sk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf1ca3781abc494243a7e1f4f8f404ad
https://doi.org/10.2220/biomedres.36.71

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1α,25(OH)2D3 downregulates gene expression levels of muscle ubiquitin ligases MAFbx and MuRF1 in human myotubes

Autor: Naohiko, Hayakawa, Junko, Fukumura, Hideyuki, Yasuno, Kaori, Fujimoto-Ouchi, Hidemitsu, Kitamura

Publikováno v: Biomedical research (Tokyo, Japan). 36(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8fd11a05be268669f665405b9380cead
https://pubmed.ncbi.nlm.nih.gov/25876656

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Impact of bevacizumab in combination with erlotinib on EGFR-mutated non-small cell lung cancer xenograft models with T790M mutation or MET amplification

Autor: Koh, Furugaki, Junko, Fukumura, Toshiki, Iwai, Keigo, Yorozu, Mitsue, Kurasawa, Mieko, Yanagisawa, Yoichiro, Moriya, Kaname, Yamamoto, Kenichi, Suda, Hiroshi, Mizuuchi, Tetsuya, Mitsudomi, Naoki, Harada

Publikováno v: International journal of cancer. 138(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a4704a23504b4c6b611a99641fb40cf
https://pubmed.ncbi.nlm.nih.gov/26370161

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Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation

Autor: Hiroshi Iida, Junko Fukumura, Takeshi Sekiguchi, Takeharu Nishimoto

Publikováno v: Experimental Cell Research. 300:213-222

We investigated the function of DDX3Y, the Y chromosome AZFa region encoding a putative DEAD-box RNA helicase protein, the loss of which results in oligozoospermia or azoospermia in humans. The human DDX3Y amino acid sequence is similar to that of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2964482f165473d0dd4d28aa5d86a391
https://doi.org/10.1016/j.yexcr.2004.07.005

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A Temperature-Sensitive Mutant of the Mammalian RNA Helicase, DEAD-BOX X Isoform, DBX, Defective in the Transition from G1 to S Phase

Autor: Takeshi Sekiguchi, Takeharu Nishimoto, Junko Fukumura, Eishi Noguchi

Publikováno v: Journal of Biochemistry. 134:71-82

ts ET24 cells are a novel temperature-sensitive (ts) mutant for cell proliferation of hamster BHK21 cells. The human genomic DNA which rescued the temperature-sensitive lethality of ts ET24 cells was isolated and screened for an open reading frame in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a076615f199baf70225fdfbbdb061958
https://doi.org/10.1093/jb/mvg126

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WITHDRAWN: Phosphorylation of dead-box RNA helicase DDX3 by mitotic cyclin B/CDC2, but not cyclin A/CDK2

Autor: Junko Fukumura, Takeshi Sekiguchi

Publikováno v: The Journal of biological chemistry.

Withdrawn by the Author.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332b2fb032810afadd246c1367ca4cfe
https://pubmed.ncbi.nlm.nih.gov/16280325

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Initial Change Of Iron Metabolic Flux Prior To Differentiation Of Erythroid Progenitors After Epoetin Beta Pegol (C.E.R.A.) Treatment

Autor: Yusuke Sasaki, Mariko Noguchi-Sasaki, Yukari Matsuo, Junko Fukumura, Fumi Sato-Inomata, Keigo Yorozu, Yasushi Shimonaka

Publikováno v: Blood. 122:3444-3444

Introduction Erythropoiesis and iron metabolism are inextricably linked. Developing immature erythroblasts have an extremely high iron requirement, especially during hemoglobin synthesis. Hepcidin, which inhibits iron efflux by binding to iron export

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ddcaff13ebb154f3710b843f815f25e
https://doi.org/10.1182/blood.v122.21.3444.3444

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