Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Junko, Murai"'
Autor:
Kohei Fujiwara, Masashi Maekawa, Yuki Iimori, Akane Ogawa, Takeshi Urano, Nobuaki Kono, Hiroyuki Takeda, Shigeki Higashiyama, Makoto Arita, Junko Murai
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108529- (2023)
Summary: Schlafen (SLFN) 11 enhances cellular sensitivity to various DNA-damaging anticancer agents. Among the human SLFNs (SLFN5/11/12/13/14), SLFN11 is unique in its drug sensitivity and ability to block replication under DNA damage. In biochemical
Externí odkaz:
https://doaj.org/article/4c15fe539cfc4f56bec45ef141dc2f8a
Autor:
Christopher Noyes, Shunsuke Kitajima, Fengkai Li, Yusuke Suita, Saradha Miriyala, Shakson Isaac, Nagib Ahsan, Erik Knelson, Amir Vajdi, Tetsuo Tani, Tran C. Thai, Derek Xu, Junko Murai, Nikos Tapinos, Chiaki Takahashi, David A. Barbie, Mamiko Yajima
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
DDX4, a conserved germline factor and RNA helicase, increases small cell lung cancer cell survival by regulating DNA damage and immune response pathways and contributes to cisplatin-mediated drug resistance.
Externí odkaz:
https://doaj.org/article/fe86a334b97d47fd9a7feeb2bdd23dba
Autor:
Yoichiro Harada, Yu Mizote, Takehiro Suzuki, Akiyoshi Hirayama, Satsuki Ikeda, Mikako Nishida, Toru Hiratsuka, Ayaka Ueda, Yusuke Imagawa, Kento Maeda, Yuki Ohkawa, Junko Murai, Hudson H Freeze, Eiji Miyoshi, Shigeki Higashiyama, Heiichiro Udono, Naoshi Dohmae, Hideaki Tahara, Naoyuki Taniguchi
Publikováno v:
eLife, Vol 12 (2023)
Mannose has anticancer activity that inhibits cell proliferation and enhances the efficacy of chemotherapy. How mannose exerts its anticancer activity, however, remains poorly understood. Here, using genetically engineered human cancer cells that per
Externí odkaz:
https://doaj.org/article/3060d83b96b647d589cb47315ff0fe2d
Autor:
Seijiro Hamada, Satoshi Kano, Junko Murai, Takayoshi Suzuki, Nayuta Tsushima, Takatsugu Mizumachi, Masanobu Suzuki, Tsuyoshi Takashima, Daiki Taniyama, Naoya Sakamoto, Yoichiro Fujioka, Yusuke Ohba, Akihiro Homma
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Recently, Schlafen family member 11 (SLFN11) has been reported to increase the sensitivity of cancer cells to DNA-damaging agents, including platinum derivatives; thus, SLFN11 may be a predictive biomarker for platinum-based chemoradiotherapy (CRT).
Externí odkaz:
https://doaj.org/article/6736169236714c84b7fe1c69b6f463b5
Autor:
Ami Maruyama, Yuzo Sato, Joji Nakayama, Junko Murai, Takamasa Ishikawa, Tomoyoshi Soga, Hideki Makinoshima
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Deoxyribonucleotide biosynthesis from ribonucleotides supports the growth of active cancer cells by producing building blocks for DNA. Although ribonucleotide reductase (RNR) is known to catalyze the rate-limiting step of de novo deoxyribonu
Externí odkaz:
https://doaj.org/article/e15465d288934f60aca475f9ca9bc802
Autor:
Takuma Kagami, Mihoko Yamade, Takahiro Suzuki, Takahiro Uotani, Shinya Tani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima, Satoshi Baba, Haruhiko Sugimura, Junko Murai, Yves Pommier, Takahisa Furuta
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Schlafen 11 (SLFN11) was recently identified as a dominant determinant of sensitivity to DNA-targeting agents including platinum-based drugs. SLFN11 also reportedly enhances cellular radiosensitivity. In this study, we examined th
Externí odkaz:
https://doaj.org/article/256db8d93cab4603a8ad3a8b3cfe40de
Autor:
Lorinc S. Pongor, Jacob M. Gross, Roberto Vera Alvarez, Junko Murai, Sang-Min Jang, Hongliang Zhang, Christophe Redon, Haiqing Fu, Shar-Yin Huang, Bhushan Thakur, Adrian Baris, Leonardo Marino-Ramirez, David Landsman, Mirit I. Aladjem, Yves Pommier
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-13 (2020)
Abstract Background Next-generation sequencing allows genome-wide analysis of changes in chromatin states and gene expression. Data analysis of these increasingly used methods either requires multiple analysis steps, or extensive computational time.
Externí odkaz:
https://doaj.org/article/b9ba48dd06a743eb8bd1a06c73e19853
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103173- (2021)
Summary: Schlafen11 (SLFN11) is referred to as interferon (IFN)-inducible. Based on cancer genomic databases, we identified human acute myeloid and lymphoblastic leukemia cells with gain-of-function mutations in the Janus kinase (JAK) family as exhib
Externí odkaz:
https://doaj.org/article/8d911496bc5d4627b0a2353ed7b9a677
Autor:
Fumiya Moribe, Momoko Nishikori, Tsuyoshi Takashima, Daiki Taniyama, Nobuyuki Onishi, Hiroshi Arima, Hiroyuki Sasanuma, Remi Akagawa, Fathi Elloumi, Shunichi Takeda, Yves Pommier, Eiichi Morii, Akifumi Takaori-Kondo, Junko Murai
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0237554 (2021)
BackgroundSLFN11 has recently been reported to execute cancer cells harboring replicative stress induced by DNA damaging agents. However, the roles of SLFN11 under physiological conditions remain poorly understood. Germinal center B-cells (GCBs) unde
Externí odkaz:
https://doaj.org/article/bd3783f480924af5b7bd34d5f263915e
Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress
Autor:
Junko Murai, Hongliang Zhang, Lorinc Pongor, Sai-Wen Tang, Ukhyun Jo, Fumiya Moribe, Yixiao Ma, Masaru Tomita, Yves Pommier
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4137-4151.e6 (2020)
Summary: Schlafen 11 (SLFN11) was recently discovered as a cellular restriction factor against replication stress. Here, we show that SLFN11 increases chromatin accessibility genome wide, prominently at active promoters in response to replication str
Externí odkaz:
https://doaj.org/article/c7b01b99da8341dabfbc2cba59cb282c