Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Junjun, Ding"'
Autor:
Wei Jin, Shaoshuai Jiang, Xinyi Liu, Yi He, Tuo Li, Jingchun Ma, Zhihong Chen, Xiaomei Lu, Xinguang Liu, Weinian Shou, Guoxiang Jin, Junjun Ding, Zhongjun Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Studies of laminopathy-based progeria offer insights into aging-associated diseases and highlight the role of LMNA in chromatin organization. Mandibuloacral dysplasia type A (MAD) is a largely unexplored form of atypical progeria that lacks
Externí odkaz:
https://doaj.org/article/4634a1454bc443bca2dcfc2e0909fc24
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract The genome is intricately folded into chromatin compartments, topologically associating domains (TADs) and loops unique to each cell type. How this higher-order genome organization regulates cell fate transition remains elusive. Here we show
Externí odkaz:
https://doaj.org/article/90e4a1a5bceb488d938ca33319a8d56b
Autor:
Xiuxiao Tang, Pengguihang Zeng, Kezhi Liu, Li Qing, Yifei Sun, Xinyi Liu, Lizi Lu, Chao Wei, Jia Wang, Shaoshuai Jiang, Jun Sun, Wakam Chang, Haopeng Yu, Hebing Chen, Jiaguo Zhou, Chengfang Xu, Lili Fan, Yi-Liang Miao, Junjun Ding
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved protein, is known to play a critical role in chromatin structure. Post-translational modifications (PTMs) diversify the functions of protein to regulate numerous cell
Externí odkaz:
https://doaj.org/article/faa4b4d14dbe448096a8ea86944969cd
Autor:
Jun Sun, Jiale Qu, Cai Zhao, Xinyao Zhang, Xinyu Liu, Jia Wang, Chao Wei, Xinyi Liu, Mulan Wang, Pengguihang Zeng, Xiuxiao Tang, Xiaoru Ling, Li Qing, Shaoshuai Jiang, Jiahao Chen, Tara S. R. Chen, Yalan Kuang, Jinhang Gao, Xiaoxi Zeng, Dongfeng Huang, Yong Yuan, Lili Fan, Haopeng Yu, Junjun Ding
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Understanding intracellular phase separation is crucial for deciphering transcriptional control, cell fate transitions, and disease mechanisms. However, the key residues, which impact phase separation the most for protein phase separation fu
Externí odkaz:
https://doaj.org/article/e247857cd6f6444bb354b68e462cbba0
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Externí odkaz:
https://doaj.org/article/b741e370895440ef94bf44d6b9c125c6
Publikováno v:
Clinical and Molecular Hepatology, Vol 29, Iss 3, Pp 643-669 (2023)
Liver organoids are three-dimensional cellular tissue models in which cells interact to form unique structures in culture. During the past 10 years, liver organoids with various cellular compositions, structural features, and functional properties ha
Externí odkaz:
https://doaj.org/article/01b4425f5fc14deca211bc0bfa23437a
Publikováno v:
Cell Regeneration, Vol 11, Iss 1, Pp 1-22 (2022)
Abstract Cell fate transition is a fascinating process involving complex dynamics of three-dimensional (3D) chromatin organization and phase separation, which play an essential role in cell fate decision by regulating gene expression. Phase separatio
Externí odkaz:
https://doaj.org/article/445186545c4448f09514c1b9db350b57
Autor:
Mingsen Li, Huaxing Huang, Bofeng Wang, Shaoshuai Jiang, Huizhen Guo, Liqiong Zhu, Siqi Wu, Jiafeng Liu, Li Wang, Xihong Lan, Wang Zhang, Jin Zhu, Fuxi Li, Jieying Tan, Zhen Mao, Chunqiao Liu, Jianping Ji, Junjun Ding, Kang Zhang, Jin Yuan, Yizhi Liu, Hong Ouyang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Genome topology provides a structural basis for epigenome-mediated transcriptional regulation in eukaryotes. Here the authors characterized the 3D genome of stratified squamous epithelia. They generated a Hi-C map of human limbal stem/progenitor cell
Externí odkaz:
https://doaj.org/article/5fa2a3c85bea42989dbd0bb933848395
Publikováno v:
Molecules, Vol 28, Iss 19, p 6915 (2023)
In this study, we present a straightforward and highly effective photo-triggered hydrogenation method for aryl halides, devoid of transition-metal catalysts. Through the synergistic utilization of light, PhNHNH2, and a base, we have successfully init
Externí odkaz:
https://doaj.org/article/e936696bf7c841df8fce6e2807c6d6d8
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-29 (2021)
Abstract Background Biomolecular condensates have been implicated in multiple cellular processes. However, the global role played by condensates in 3D chromatin organization remains unclear. At present, 1,6-hexanediol (1,6-HD) is the only available t
Externí odkaz:
https://doaj.org/article/87cfdac85a1e4dc1977bd0aa9aee2df9