Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Junji Sagara"'
Autor:
Tadayoshi Karasawa, Akira Kawashima, Fumitake Usui, Hiroaki Kimura, Koumei Shirasuna, Yoshiyuki Inoue, Takanori Komada, Motoi Kobayashi, Yoshiko Mizushina, Junji Sagara, Masafumi Takahashi
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 348-356 (2015)
Increasing evidence indicates that caspase recruitment domain (CARD)‐mediated caspase‐1 (CASP1) assembly is an essential process for its activation and subsequent interleukin (IL)‐1β release, leading to the initiation of inflammation. Both CAR
Externí odkaz:
https://doaj.org/article/95e95b4fde7c4e91830b0160ad884702
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113289 (2014)
Proteins that belong to the protein phosphatase 1 and actin regulator (phactr) family are involved in cell motility and morphogenesis. However, the mechanisms that regulate the actin cytoskeleton are poorly understood. We have previously shown that p
Externí odkaz:
https://doaj.org/article/0589b439a4e44738a96158346918555e
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4247 (2009)
Scapinin, also named phactr3, is an actin and protein phosphatase 1 (PP1) binding protein, which is expressed in the adult brain and some tumor cells. At present, the role(s) of scapinin in the brain and tumors are poorly understood. We show that the
Externí odkaz:
https://doaj.org/article/30feccff4d984ad69792f9c52685c5bf
Autor:
Kazuhiko Matsushita, Michiko Takeoka, Junji Sagara, Naoki Itano, Yuka Kurose, Akihiro Nakamura, Shun'ichiro Taniguchi
Publikováno v:
Mediators of Inflammation, Vol 2009 (2009)
The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 an
Externí odkaz:
https://doaj.org/article/0ec5cff620fe43af9d51bbee3dbc884f
Autor:
Jun Nakayama, Yoshiko Sato, Masayoshi Kato, Mana Fukushima, Shigenori Yamada, Junji Sagara, Hiroyoshi Ota, Satoshi Ishizone, Takehisa Matsumoto, Meguru Ikeyama, Kazuki Horiuchi, Hitomi Komura, Masatomo Kawakubo
Publikováno v:
Histochemistry and Cell Biology. 148:463-471
Helicobacter suis (H. suis), formerly called Helicobacter heilmannii type 1 (H. heilmannii), is a gram-negative bacterium of the Helicobacter species. This pathogen infects the stomach of humans and animals such as dogs, cats, pigs, and rodents, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f0f4926b4e098608baa1b6225e4b91
https://doi.org/10.1007/s00418-017-1582-4
https://doi.org/10.1007/s00418-017-1582-4
Autor:
Tetsuo Noda, Akira Kawashima, Yoshikazu Yasuda, Fumitake Usui, Toshihiko Yada, Yoichiro Iwakura, Shun'ichiro Taniguchi, Masafumi Takahashi, Yoshiyuki Inoue, Tadayoshi Karasawa, Satoshi Nishimura, Ken Yanagisawa, Hiroaki Kimura, Junji Sagara, Koumei Shirasuna, Katsuya Dezaki, Kenji Tago, Hiroko Tsutsui
Publikováno v:
The Journal of Immunology. 192:4342-4351
Inflammation plays a key role in the pathophysiology of hepatic ischemia–reperfusion (I/R) injury. However, the mechanism by which hepatic I/R induces inflammatory responses remains unclear. Recent evidence indicates that a sterile inflammatory res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7232a3cf2d093e46198e663b0f83d78
https://doi.org/10.4049/jimmunol.1302039
https://doi.org/10.4049/jimmunol.1302039
Autor:
Fumitake Usui, Koumei Shirasuna, Masafumi Takahashi, Akira Kawashima, Shun'ichiro Taniguchi, Satoshi Nishimura, Takanori Komada, Tadayoshi Karasawa, Tetsuo Noda, Shigeaki Muto, Hiroaki Kimura, Junji Sagara, Eiji Kusano, Daisuke Nagata
Publikováno v:
The American Journal of Pathology. 184:1287-1298
Inflammation plays a crucial role in the pathophysiological characteristics of chronic kidney disease; however, the inflammatory mechanisms underlying the chronic kidney disease process remain unclear. Recent evidence indicates that sterile inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb7817f51428b7991ace201b69d75a5
https://doi.org/10.1016/j.ajpath.2014.01.014
https://doi.org/10.1016/j.ajpath.2014.01.014
Autor:
Junji Sagara, Seokwon Kang, Katherine A. Fitzgerald, Connor Anderson, Teresa Fernandes-Alnemri, Emad S. Alnemri
Publikováno v:
The Journal of Immunology. 191:3995-3999
Activation of the NLRP3 inflammasome by diverse stimuli requires a priming signal from TLRs and an activation signal from purinergic receptors or pore-forming toxins. In this study, we demonstrate, through detailed analysis of NLRP3 activation in mac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b4dcf6dbdeb9c0f75c605691f3559e
https://doi.org/10.4049/jimmunol.1301681
https://doi.org/10.4049/jimmunol.1301681
Autor:
Shigeaki Hida, Koumei Shirasuna, Junji Sagara, Akira Kawashima, Fumitake Usui, Kazuki Tatsumi, Shun'ichiro Taniguchi, Tadayoshi Karasawa, Hiroaki Kimura, Masafumi Takahashi
Publikováno v:
Biochemical and Biophysical Research Communications. 425:162-168
Objective Recent investigations have suggested that the inflammasome plays a role in the development of vascular inflammation and atherosclerosis; however, its precise role remains controversial. We produced double-deficient mice for apolipoprotien E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d5271588f26d17fa255890aab30635
https://doi.org/10.1016/j.bbrc.2012.07.058
https://doi.org/10.1016/j.bbrc.2012.07.058
Autor:
Atsushi Izawa, Takeki Hata, Fumitake Usui, Hajime Morimoto, Yuichiro Kashima, Masafumi Takahashi, Shun'ichiro Taniguchi, Masanori Kawaguchi, Jun Nakayama, Minoru Hongo, Uichi Ikeda, Jun Koyama, Tetsuo Noda, Junya Masumoto, Junji Sagara, Yasuko Takahashi
Publikováno v:
Circulation. 123:594-604
Background— Inflammation plays a key role in the pathophysiology of myocardial ischemia/reperfusion (I/R) injury; however, the mechanism by which myocardial I/R induces inflammation remains unclear. Recent evidence indicates that a sterile inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20eb39af6893128ce3545b26ef5ae7e4
https://doi.org/10.1161/circulationaha.110.982777
https://doi.org/10.1161/circulationaha.110.982777