Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Junji Morokuma"'
Publikováno v:
Frontiers in Ophthalmology, Vol 4 (2024)
The aim of the present study is to investigate the role of c-Jun N-terminal kinase (JNK) and matrix metalloproteinase-2 (MMP-2) in mediating the effects of interleukin-1β (IL-1β) on the function of lacrimal gland myoepithelial cells (MECs). MECs is
Externí odkaz:
https://doaj.org/article/ba2ae144cdd84af7a954db41482fc6c1
Autor:
Maya Emmons-Bell, Fallon Durant, Angela Tung, Alexis Pietak, Kelsie Miller, Anna Kane, Christopher J. Martyniuk, Devon Davidian, Junji Morokuma, Michael Levin
Publikováno v:
iScience, Vol 22, Iss , Pp 147-165 (2019)
Summary: Anatomical homeostasis results from dynamic interactions between gene expression, physiology, and the external environment. Owing to its complexity, this cellular and organism-level phenotypic plasticity is still poorly understood. We establ
Externí odkaz:
https://doaj.org/article/87cd9d4ff53047e7b78641f8e8551f22
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006904 (2019)
Control of axial polarity during regeneration is a crucial open question. We developed a quantitative model of regenerating planaria, which elucidates self-assembly mechanisms of morphogen gradients required for robust body-plan control. The computat
Externí odkaz:
https://doaj.org/article/9db2fa1326de4be9884213d00bc331f8
Autor:
Maya Emmons-Bell, Fallon Durant, Jennifer Hammelman, Nicholas Bessonov, Vitaly Volpert, Junji Morokuma, Kaylinnette Pinet, Dany S. Adams, Alexis Pietak, Daniel Lobo, Michael Levin
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 11, Pp 27865-27896 (2015)
The shape of an animal body plan is constructed from protein components encoded by the genome. However, bioelectric networks composed of many cell types have their own intrinsic dynamics, and can drive distinct morphological outcomes during embryogen
Externí odkaz:
https://doaj.org/article/c7aea5e8cf5f4ee481eaf0ab00dcba46
Publikováno v:
Front Ophthalmol (Lausanne)
In the lacrimal gland, myoepithelial cells (MEC) express muscle contractile proteins such as alpha smooth muscle actin (SMA) and calponin and therefore can contract to help expel lacrimal fluid. In a previous study, we demonstrated that lacrimal glan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609dead6a16def93225213c64747d69d
https://doi.org/10.3389/fopht.2022.873486
https://doi.org/10.3389/fopht.2022.873486
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9f68fbba30000958ff30670d8b50241
https://doi.org/10.2139/ssrn.4295698
https://doi.org/10.2139/ssrn.4295698
Autor:
Anna Kane, Christopher J. Martyniuk, Fallon Durant, Angela Tung, Maya Emmons-Bell, Junji Morokuma, Kelsie A. Miller, Michael Levin, Alexis Pietak, Devon Davidian
Publikováno v:
iScience, Vol 22, Iss, Pp 147-165 (2019)
iScience
iScience
Summary Anatomical homeostasis results from dynamic interactions between gene expression, physiology, and the external environment. Owing to its complexity, this cellular and organism-level phenotypic plasticity is still poorly understood. We establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b2b1ad4fdf9a6e9e614fa7f1af68b1
http://www.sciencedirect.com/science/article/pii/S258900421930464X
http://www.sciencedirect.com/science/article/pii/S258900421930464X
Autor:
Katherine B. Williams, Junji Morokuma, Kelsie A. Miller, Jennifer V. LaPalme, Chris Fields, Michael Levin, Johanna Bischof
Regeneration requires the production of large numbers of new cells, and thus cell division regulators, particularly ERK signaling, are critical in regulating this process. In the highly regenerative planarian flatworm, questions remain as to whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbfa589976bb2c24d0f4e5e70417d444
https://doi.org/10.1101/2021.01.15.426822
https://doi.org/10.1101/2021.01.15.426822
Autor:
Junji Morokuma, Quentin Wattiaux, Driss Zoukhri, Gustavo Ortiz, Georgios Hatzipetrou, Pedram Hamrah, Michael Mariano, Salome Aubry, Angela Gárriz, Maytal Bowman, Darlene A. Dartt, Jeffrey Bair
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose We reported that oxytocin (OXT), added to freshly prepared lacrimal gland lobules, induced myoepithelial cell (MEC) contraction. In other systems, OXT activates phospholipase C (PLC) generating Inositol 1,4,5-trisphosphate (IP3) which increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5d26a15f93f854f744722092b9f17b
https://doi.org/10.1167/iovs.62.14.25
https://doi.org/10.1167/iovs.62.14.25
Autor:
Katherine B. Williams, Kris Kimel, Mahendra Jain, Fallon Durant, Douglas J. Blackiston, Junji Morokuma, Michael Levin, Twyman Clements, David W. Reed, Michael Roberts, Sunia A. Trauger, Joshua M. Finkelstein, Benjamin E. Wolfe
Publikováno v:
Regeneration
Regeneration is regulated not only by chemical signals but also by physical processes, such as bioelectric gradients. How these may change in the absence of the normal gravitational and geomagnetic fields is largely unknown. Planarian flatworms were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c171e5fb007393f648a15b596982c106
https://doi.org/10.1002/reg2.79
https://doi.org/10.1002/reg2.79