Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Junji Kamon"'
Autor:
Kota Yano, Hideki Fujii, Takeshi Okanoue, Michihisa Moriguchi, Junji Kamon, Kohichiroh Yasui, Aya Takahashi, Yu Liu, Keiichiroh Okuda, Daiki Takahashi, Atsushi Umemura, Yoshito Itoh, Seita Kataoka, Kanji Yamaguchi, Yusuke Ito, Nozomi Tochiki, Yuya Seko, Hiroshi Ishiba, Shinya Okishio
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
We explored the beneficial effects of GW7647, a peroxisome proliferator activated receptor α (PPARα) agonist, and metformin, an anti-diabetic drug on an advanced nonalcoholic steatohepatitis (NASH) model in rodents and investigated the possible mec
Autor:
Shun Saito, Takehiko Inohana, Masahiko Irie, Misa Hayashi, Kenji Goryo, Junji Kamon, Kenta Kagaya, Masako Tanabe, Rieko Matsumura, Kuniyoshi Koyachi, Takashi Miyano
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 94:2-P1
Autor:
Kenzo Takahashi, Shiro Nakaike, Miyuki Hori, Akihiko Hoshino, Junji Kamon, Nobutomo Tsuruzoe, Yumiko Asakura, Takehisa Iwama, Shuya Takahashi, Masafumi Kawanishi
Publikováno v:
European Journal of Pharmacology. 618:63-69
We evaluated the effects of NT-702 (parogrelil hydrochloride, NM-702, 4-bromo-6-[3-(4-chlorophenyl) propoxy]-5-[(pyridine-3-ylmethyl) amino] pyridazin-3(2H)-one hydrochloride), a selective phosphodiesterase 3 inhibitor, on the asthmatic response in g
Autor:
Junji Kamon, Kajuro Komeda, Shunbun Kita, Junji Matsui, Toshimasa Yamauchi, Kazuhiro Eto, Naoto Kubota, Mitsuhiko Noda, Takashi Kadowaki, Tokuyuki Yamashita, Yasuo Terauchi, Iseki Takamoto
Publikováno v:
Diabetes. 53:2844-2854
Heterozygous peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-deficient (PPARgamma(+/-)) mice were protected from high-fat diet-induced insulin resistance. To determine the impact of systemic reduction of PPAR-gamma activity on beta-cell
Autor:
Junji Kamon, Shinichi Aizawa, Yasuo Terauchi, Motowo Tomita, Toshimasa Yamauchi, Junji Matsui, Naoto Kubota, Kajuro Komeda, Yasuo Akanuma, Takashi Kadowaki
Publikováno v:
Diabetes. 53:2261-2270
Mice lacking the p85alpha regulatory subunit of phosphoinositide (PI) 3-kinase (Pik3r1(-/-)) showed increased glucose uptake in white adipose tissue (WAT) and skeletal muscle due to increased phosphatidylinositol (3,4,5)-triphosphate [PtdIns(3,4,5)P3
Autor:
Shunbun Kita, Junji Kamon, Toshimasa Yamauchi, S. Uchida, Satoshi Kimura, Takashi Kadowaki, Kazuo Hara, Yusuke Hada, Yusuke Ito, Ryozo Nagai, Philippe Froguel, Francis Vasseur, Hironori Waki
Publikováno v:
Journal of Biological Chemistry. 278:40352-40363
Adiponectin is an adipocyte-derived hormone, which has been shown to play important roles in the regulation of glucose and lipid metabolism. Eight mutations in human adiponectin have been reported, some of which were significantly related to diabetes
Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis
Autor:
Kajuro Komeda, Yasushi Imai, Junji Matsui, Yusuke Ito, Ken Ichi Yamamura, Philippe Froguel, Junji Kamon, K. Hioki, Makoto Takata, Toshimasa Yamauchi, Yasuo Terauchi, Nobuhiro Shimozawa, Masaki Tsunoda, A. Ryozo Nagai, Yoshito Ueyama, Kazuhiro Eto, S. Uchida, Takeshi Naitoh, Koji Murakami, Hironori Waki, Satoshi Kimura, Keisuke Takakuwa, Takashi Kadowaki, Yasuyuki Ohnishi
Publikováno v:
Journal of Biological Chemistry. 278:2461-2468
The adipocyte-derived hormone adiponectin has been shown to play important roles in the regulation of energy homeostasis and insulin sensitivity. In this study, we analyzed globular domain adiponectin (gAd) transgenic (Tg) mice crossed with leptin-de
Autor:
Toshimasa Yamauchi, Naoto Kubota, Ryozo Nagai, Kajuro Komeda, Yasuo Terauchi, Kazuyuki Tobe, Yasuo Akanuma, Satoshi Kimura, Junji Kamon, Koji Murakami, Hiroshi Miki, Tomohiro Ide, Takashi Kadowaki, Atsuko Tsuchida, Hironori Waki, Kiyoto Motojima
Publikováno v:
Journal of Biological Chemistry. 276:41245-41254
Peroxisome proliferator-activated receptor (PPAR) gamma is a ligand-activated transcription factor and a member of the nuclear hormone receptor superfamily that is thought to be the master regulator of fat storage; however, the relationship between P
Autor:
Kiyoto Motojima, Junji Kamon, Akiko Itai, Koichi Shudo, Hiroyuki Kagechika, Hironori Waki, Nobuyo Tsuboyama-Kasaoka, Shigeaki Kato, Hiroshi Miki, Ryozo Nagai, Koji Murakami, Masashi Fukayama, Kajuro Komeda, Yasuo Terauchi, Naoko Yamauchi, Yasuo Akanuma, Kazuyuki Tobe, Tomohiro Ide, Toshimasa Yamauchi, Naoto Kubota, Takashi Kadowaki, Osamu Ezaki, Atsuko Tsuchida, Wataru Hori, Satoshi Kimura
Publikováno v:
Journal of Clinical Investigation. 108:1001-1013
PPARgamma is a ligand-activated transcription factor and functions as a heterodimer with a retinoid X receptor (RXR). Supraphysiological activation of PPARgamma by thiazolidinediones can reduce insulin resistance and hyperglycemia in type 2 diabetes,
Autor:
Junji Matsui, Yasuo Akanuma, Ryo Suzuki, Yasuo Terauchi, Atsuko Tsuchida, Takashi Kadowaki, Ryozo Nagai, Junji Kamon, Hiroshi Miki, Satoshi Kimura, Kajuro Komeda, Yasushi Kaburagi, Toshimasa Yamauchi, Naoto Kubota, Kazuyuki Tobe
Publikováno v:
Molecular and Cellular Biology. 21:2521-2532
To investigate the role of insulin receptor substrate 1 (IRS-1) and IRS-2, the two ubiquitously expressed IRS proteins, in adipocyte differentiation, we established embryonic fibroblast cells with four different genotypes, i.e., wild-type, IRS-1 defi