Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Junji Hamuro"'
Autor:
Takafumi Miyatani, Hiroshi Tanaka, Kosaku Numa, Asako Uehara, Yohei Otsuki, Junji Hamuro, Shigeru Kinoshita, Chie Sotozono
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Age-related macular degeneration (AMD) is associated with the dysfunction and degeneration of retinal pigment epithelium (RPE) cells. Here, we examined how the formation and expansions of cell clusters are regulated by the differentiation of
Externí odkaz:
https://doaj.org/article/6eba146a1c6e4c98bb63eaafa763a217
Autor:
Morio Ueno, MD, PhD, Kengo Yoshii, PhD, Tomoko Yamashita, PhD, Kazuhiro Sonomura, PhD, Kazuko Asada, BEng, Eiko Ito, BSci, Tomoko Fujita, BEd, Chie Sotozono, MD, PhD, Shigeru Kinoshita, MD, PhD, Junji Hamuro, PhD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 3, Pp 100299- (2023)
Purpose: The purpose of the study was to clarify the interplay between metabolites and microRNAs (miRs) in the aqueous humor (AqH) of bullous keratopathy (BK) patients to retain human corneal endothelium (HCE) integrity. Design: Prospective, comparat
Externí odkaz:
https://doaj.org/article/cabf9c0d46004751afc2079ae9d7e9ea
Autor:
Munetoyo Toda, Morio Ueno, Jun Yamada, Asako Hiraga, Kazuko Asada, Junji Hamuro, Chie Sotozono, Shigeru Kinoshita
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract This study aims to clarify the immunogenicity in acquired and innate immune responses of cultured human corneal endothelial cells (hCECs) applied for cell injection therapy, a newly established modality for corneal endothelium failures. Thir
Externí odkaz:
https://doaj.org/article/0ac3782f0d1648d4906ef7600e52e045
Autor:
Hideto Deguchi, Tomoko Yamashita, Nao Hiramoto, Yohei Otsuki, Atsushi Mukai, Morio Ueno, Chie Sotozono, Shigeru Kinoshita, Junji Hamuro
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract This study aimed to uncover the mechanism responsible for the clinical efficacy of cell injection therapy with fully differentiated cultured cells. Analysis of polarized expression of ion transporters on cultured human corneal endothelial ce
Externí odkaz:
https://doaj.org/article/90321856ceb94fd58470874fa3fdc7a0
Cellular Interplay Through Extracellular Vesicle miR-184 Alleviates Corneal Endothelium Degeneration
Autor:
Tomoko Yamashita, PhD, Kazuko Asada, BEng, Morio Ueno, MD, PhD, Nao Hiramoto, PhD, Tomoko Fujita, BEd, Munetoyo Toda, PhD, Chie Sotozono, MD, PhD, Shigeru Kinoshita, MD, PhD, Junji Hamuro, PhD
Publikováno v:
Ophthalmology Science, Vol 2, Iss 4, Pp 100212- (2022)
Objective: The objective of the study was to reveal the presence of cellular interplay through extracellular vesicle (EV) microRNAs (miRs), to dampen the vicious cycle to degenerate human corneal endothelium (HCE) tissues. Design: Prospective, compar
Externí odkaz:
https://doaj.org/article/aa52be25f2df4ba9b6960edbc26679ba
Autor:
Nobuhiro Terao, Hideki Koizumi, Kentaro Kojima, Tetsuya Yamagishi, Yuji Yamamoto, Kengo Yoshii, Koji Kitazawa, Asako Hiraga, Munetoyo Toda, Shigeru Kinoshita, Chie Sotozono, Junji Hamuro
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV,
Externí odkaz:
https://doaj.org/article/96cf22a30aaf4687a79a10be48d9748d
Autor:
Naoki Okumura, EunDuck P Kay, Makiko Nakahara, Junji Hamuro, Shigeru Kinoshita, Noriko Koizumi
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e58000 (2013)
Corneal endothelial dysfunctions occurring in patients with Fuchs' endothelial corneal dystrophy, pseudoexfoliation syndrome, corneal endotheliitis, and surgically induced corneal endothelial damage cause blindness due to the loss of endothelial func
Externí odkaz:
https://doaj.org/article/1d4732e1bf6241769e429c85f2853e67
Autor:
Naoki Okumura, Munetoyo Toda, Kohsaku Numa, John Bush, Motomu Tanaka, Noriko Koizumi, Junji Hamuro, Akihisa Yamamoto, Kojiro Imai, Shigeru Kinoshita, Hiroshi Tanaka, Chie Sotozono, Satoshi Teramukai, Morio Ueno
Publikováno v:
American Journal of Ophthalmology. 237:267-277
PURPOSE To investigate the safety and efficacy of cultured human corneal endothelial cell (hCEC)-injection therapy with mature differentiated (mature) cell subpopulations (SPs) for corneal endothelial failure (CEF). DESIGN Comparative, interventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2222ab4278a79602ae9ee7e39561ff
https://doi.org/10.1016/j.ajo.2021.11.012
https://doi.org/10.1016/j.ajo.2021.11.012
Autor:
Koji Kitazawa, Chie Sotozono, Hiroshi Tanaka, Noriko Koizumi, Kojiro Imai, Naoki Okumura, Kohsaku Numa, Morio Ueno, John Bush, Satoshi Teramukai, Junji Hamuro, Shigeru Kinoshita
Publikováno v:
Ophthalmology. 128:504-514
Purpose To report the safety and efficacy of a novel cell injection therapy using cultured human corneal endothelial cells (hCECs) for endothelial failure conditions via the report of the long-term 5-year postoperative clinical data from a first-in-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d6e95df5e53e1c44b2deebe41a2ae0
https://doi.org/10.1016/j.ophtha.2020.09.002
https://doi.org/10.1016/j.ophtha.2020.09.002
Autor:
Atsushi Mukai, Hiroki Hatanaka, Eiko Ito, Junji Hamuro, Shigeru Kinoshita, Morio Ueno, Chie Sotozono
Publikováno v:
Biochemical and Biophysical Research Communications. 544:31-37
To clarify the influence of tumor necrosis factor (TNF)-α on fibrotic phenotypes induced by transforming growth factor (TGF)-β in retinal pigment epithelial cells (RPECs) by epigenetic regulation. Human primary retinal pigment epithelial cells (RPE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7332096173894f8143243624d75e87
https://doi.org/10.1016/j.bbrc.2021.01.060
https://doi.org/10.1016/j.bbrc.2021.01.060