Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Junji Ezaki"'
Autor:
Yuzuru Watanabe, Naoyuki Okabe, Junji Ezaki, Yutaka Shio, Satoshi Waguri, Shinya Watanabe, Reiko Honma, Yuki Matsumura, Hironori Takagi, Hirosumi Tamura, Jun-ichi Imai, Satoshi Muto, Hiroyuki Suzuki, Takeo Hasegawa, Mitsuro Fukuhara, Emi Ito, Mika Hoshino, Yuki Ozaki, Takuya Inoue, Yuka Yanagisawa, Takumi Yamaura, Jun Osugi
Publikováno v:
Oncology Letters
Lung adenocarcinoma (ADC) patients with tumors that harbor no targetable driver gene mutation, such as epidermal growth factor receptor (EGFR) gene mutations, have unfavorable prognosis, and thus, novel therapeutic targets are required. Family with s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9d424f50953a3b73949cf78249984c
http://europepmc.org/articles/PMC5776887
http://europepmc.org/articles/PMC5776887
Autor:
Yuu Dobashi, Kiyoaki Katahira, Shinya Watanabe, Michiyuki Hakozaki, Takahiro Tajino, Shinichi Konno, Yoichi Kaneuchi, Hirosumi Tamura, Kouki Kato, Junji Ezaki, Hitoshi Yamada, Satoshi Waguri, Aki Yoshida
Publikováno v:
Anticancer research. 38(9)
Background/aim Clear cell sarcoma (CCS) of soft tissue is exceedingly rare and frequently exhibits aggressive behavior. Toward the goals of improving the aggressive course and poor prognosis of CCS, and establish new therapeutic methods, molecular ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855bee9371740695e649c1d03ae2c76e
https://pubmed.ncbi.nlm.nih.gov/30194147
https://pubmed.ncbi.nlm.nih.gov/30194147
Autor:
Jun Osugi, Emi Ito, Naoyuki Okabe, Reiko Honma, Hirosumi Tamura, Shinya Watanabe, Jun-ichi Imai, Yuka Yanagisawa, Junji Ezaki, Mitsukazu Gotoh, Satoshi Waguri, Takumi Yamaura, Satoshi Muto, Hiroyuki Suzuki
Publikováno v:
International Journal of Oncology
Personalized therapy for non-small cell lung cancer (NSCLC), particularly lung adenocarcinoma, has recently been significantly improved by the discovery of various molecular targets. However, this has not been the case for lung squamous cell carcinom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d24ad39b7efa06481be1465879a2ba
https://doi.org/10.3892/ijo.2015.2817
https://doi.org/10.3892/ijo.2015.2817
Autor:
Tsutomu Fujimura, Masaaki Komatsu, Shigeto Sato, Keiji Tanaka, Junji Ezaki, Sanae Soma, Takashi Ueno, Norihiko Furuya, Shin-ichi Ikeda, Nobutaka Hattori, Norihiro Tada, Eri Arikawa-Hirasawa, Eiki Kominami, Juan Alejandro Oliva Trejo, Mitsue Takeda-Ezaki
Publikováno v:
Autophagy. 10:631-641
Skeletal muscle atrophy is thought to result from hyperactivation of intracellular protein degradation pathways, including autophagy and the ubiquitin–proteasome system. However, the precise contributions of these pathways to muscle atrophy are unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43b2d8bf6c8cb0114fe7f718c627bdc
https://doi.org/10.4161/auto.27785
https://doi.org/10.4161/auto.27785
Autor:
Junji Ezaki, Takashi Ueno, Dong-Mei Zheng, Norihiro Tada, Juan Alejandro Oliva Trejo, Zehua Bian, Norihiko Furuya
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:120-124
Ferulic acid (FA), a naturally occurring polyphenol abundant in vegetables and rice bran, is known to possess a potent antioxidant activity, thereby protecting cells from oxidative stress. In the present study, we show that in addition to its known a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e285a89ca8f0c78776e861eac13eb3
https://doi.org/10.1248/bpb.b12-00695
https://doi.org/10.1248/bpb.b12-00695
Autor:
Reiko Honma, Zenichiro Saze, Akira Nishikawa, Shigeru Marubashi, Yuko Hashimoto, Takeshi Tada, Satoshi Waguri, Michihiko Kogure, Mitsukazu Gotoh, Shinya Watanabe, Masamitu Unakami, Kazuhiro Tasaki, Junji Ezaki, Hirosumi Tamura, Jun-ichi Imai
Publikováno v:
International journal of oncology. 51(3)
Basaloid squamous cell carcinoma of the esophagus (BSCE) is a rare variant of squamous cell carcinoma that is difficult to distinguish from other carcinomas by preoperative endoscopic biopsy because of its histological varieties. Accurate diagnosis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f456b6fff9ec464621ac8c95b3ebed1f
https://pubmed.ncbi.nlm.nih.gov/28731134
https://pubmed.ncbi.nlm.nih.gov/28731134
Autor:
Manabu Funayama, Yasuo Uchiyama, Shigeto Sato, Masato Koike, Takahiro Fukuda, Junji Ezaki, Takashi Ueno, Nobutaka Hattori
Publikováno v:
The American journal of pathology. 186(12)
Kufor-Rakeb syndrome (KRS) is an autosomal recessive form of early-onset parkinsonism linked to the PARK9 locus. The causative gene for KRS is Atp13a2 , which encodes a lysosomal type 5 P-type ATPase. We recently showed that KRS/ PARK9 -linked mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51944131eb2a80cd2a6615a66341d520
https://pubmed.ncbi.nlm.nih.gov/28071821
https://pubmed.ncbi.nlm.nih.gov/28071821
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1824:51-58
Pioneering work on autophagy was achieved soon after the discovery of lysosomes more than 50 years ago. Due to its prominent lysosomal activity and technical ease of handling, the liver has been at the center of continuous and vigorous investigations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6de3ca45bf02b6109cc8b4fb07abc8
https://doi.org/10.1016/j.bbapap.2011.06.019
https://doi.org/10.1016/j.bbapap.2011.06.019
Publikováno v:
IUBMB Life. 63:1001-1008
This review summarizes the historical aspects of the study of peroxisome degradation in mammalian cells. Peroxisomes have diverse metabolic roles in response to environmental changes and are degraded in a preferential manner, by comparison with cytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429782b74478a21175d475e25cfd3bbb
https://doi.org/10.1002/iub.537
https://doi.org/10.1002/iub.537
Autor:
Junji Ezaki, Eiki Kominami, Yoshinobu Ichimura, Taichi Kumanomidou, Takashi Ueno, Masaaki Komatsu, Tsunehiro Mizushima, Takashi Yamane, Yu-shin Sou, Keiji Tanaka
Publikováno v:
Journal of Biological Chemistry. 283:22847-22857
Impairment of autophagic degradation of the ubiquitin- and LC3-binding protein "p62" leads to the formation of cytoplasmic inclusion bodies. However, little is known about the sorting mechanism of p62 to autophagic degradation. Here we identified a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cff62a95c8cc0adcc6d2090a8c7c386
https://doi.org/10.1074/jbc.m802182200
https://doi.org/10.1074/jbc.m802182200