Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Junier Ivan"'
Publikováno v:
Front. Microbiol. 14:1192831 (2023)
DNA supercoiling is central to many fundamental processes of living organisms. Its average level along the chromosome and over time reflects the dynamic equilibrium of opposite activities of topoisomerases, which are required to relax mechanical stre
Externí odkaz:
http://arxiv.org/abs/2303.10819
Just as in eukaryotes, high-throughput chromosome conformation capture (Hi-C) data have revealed nested organizations of bacterial chromosomes into overlapping interaction domains. In this chapter, we present a multiscale analysis framework aiming at
Externí odkaz:
http://arxiv.org/abs/2010.01718
Autor:
Joyeux, Marc, Junier, Ivan
Publikováno v:
Biophysical Journal 119 (2020) 1215-1225
Bacterial genomes have been shown to be partitioned into several kilobases long chromosomal domains that are topologically independent from each other, meaning that change of DNA superhelicity in one domain does not propagate to neighbors. Both in vi
Externí odkaz:
http://arxiv.org/abs/2008.05973
Publikováno v:
Algorithms for Molecular Biology, Vol 5, Iss 1, p 31 (2010)
Abstract Background The specific position of functionally related genes along the DNA has been shown to reflect the interplay between chromosome structure and genetic regulation. By investigating the statistical properties of the distances separating
Externí odkaz:
https://doaj.org/article/1350b10f169d4fe5af98bcf4304cc1cd
Autor:
Walter, Jean-Charles, Lepage, Thibaut, Dorignac, Jérôme, Geniet, Frédéric, Parmeggiani, Andrea, Palmeri, John, Bouet, Jean-Yves, Junier, Ivan
We investigate the measurement of DNA supercoiling density ($\sigma$) along chromosomes using interaction frequencies between DNA and DNA-anchored clusters of proteins. Specifically, we show how the physics of DNA supercoiling leads, in bacteria, to
Externí odkaz:
http://arxiv.org/abs/2002.00111
Autor:
Lepage, Thibaut, Junier, Ivan
DNA supercoiling, the under or overwinding of DNA, is a key physical mechanism both participating to compaction of bacterial genomes and making genomic sequences adopt various structural forms. DNA supercoiling may lead to the formation of braided su
Externí odkaz:
http://arxiv.org/abs/1904.11453
Akademický článek
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In condensed matter physics, simplified descriptions are obtained by coarse-graining the features of a system at a certain characteristic length, defined as the typical length beyond which some properties are no longer correlated. From a physics stan
Externí odkaz:
http://arxiv.org/abs/1801.07585
Autor:
Lepage, Thibaut, Junier, Ivan
Under supercoiling constraints, naked DNA, such as a large part of bacterial DNA, folds into braided structures called plectonemes. The double-helix can also undergo local structural transitions, leading to the formation of denaturation bubbles and o
Externí odkaz:
http://arxiv.org/abs/1708.02194
Publikováno v:
In Cell Reports 3 November 2020 33(5)