Výsledky vyhledávání - "Junichi YANO"

Akademický článek

Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection.

Autor: Shin-ichiro Nakagawa, Yuichi Hirata, Takeshi Kameyama, Yuko Tokunaga, Yasumasa Nishito, Kazuko Hirabayashi, Junichi Yano, Takahiro Ochiya, Chise Tateno, Yasuhito Tanaka, Masashi Mizokami, Kyoko Tsukiyama-Kohara, Kazuaki Inoue, Makoto Yoshiba, Akinori Takaoka, Michinori Kohara

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59611 (2013)

BACKGROUND & AIMS:The interferon (IFN) system plays a critical role in innate antiviral response. We presume that targeted induction of IFN in human liver shows robust antiviral effects on hepatitis C virus (HCV) and hepatitis B virus (HBV). METHODS:

Externí odkaz: https://doaj.org/article/5b598e4cbbab4c8995d011dff0aefa26

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Data from Tumor Regression in Mice by Delivery of Bcl-2 Small Interfering RNA with Pegylated Cationic Liposomes

Autor: Junichi Yano, Tadaaki Ohgi, Kazuko Hirabayashi, Kazuchika Takagaki, Yohei Sato, Kae Fujiwara, Toshihiro Ueda, Satoru Sonoke

The pharmacokinetics and antitumor activity of pegylated small interfering RNA (siRNA)/cationic liposome complexes were studied after systemic administration to mice. We designed pegylated-lipid carriers for achieving increased plasma concentrations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83b26225a542ea55c1aa86776795955c
https://doi.org/10.1158/0008-5472.c.6497562

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Naked antisense double-stranded DNA oligonucleotide efficiently suppresses BCR-ABL positive leukemic cells

Autor: Toshimi Hoshiko, Shinya Kimura, Junichi Yano, Takuya Akisawa, Yasushi Kubota, Tatsuro Watanabe, Kazuaki Tanigawara

Publikováno v: Investigational New Drugs. 38:1012-1019

Oligonucleotide-based gene silencing, using molecules such as antisense oligonucleotides (ASOs), small interfering RNA, and aptamers, is widely studied. Another approach uses DNA/RNA heteroduplex oligonucleotides (HDOs). Here, we developed an antisen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0d1155dc450fa4755e9a95c9a6d6de
https://doi.org/10.1007/s10637-019-00862-9

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Synthesis and biological activity of artificial mRNA prepared with novel phosphorylating reagents

Autor: Hirofumi Masuda, Seigo Nagata, Koichi Uetake, Natsuhisa Oka, Tomohiro Hamasaki, Kazuchika Takagaki, Junichi Yano, Takeshi Wada, Tadaaki Ohgi

Publikováno v: Nucleic Acids Research

Though medicines that target mRNA are under active investigation, there has been little or no effort to develop mRNA itself as a medicine. Here, we report the synthesis of a 130-nt mRNA sequence encoding a 33-amino-acid peptide that includes the sequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3c41e62802a594291aa157c7e6d58d
http://europepmc.org/articles/PMC2995060

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Chemical synthesis of diastereomeric diadenosine boranophosphates (ApbA) from 2′-O-(2-cyanoethoxymethyl)adenosine by the boranophosphotriester method

Autor: Takeshi Wada, Hidetoshi Kitagawa, Yutaka Masutomi, Yukiko Enya, Tadaaki Ohgi, Seigo Nagata, Kazuchika Takagaki, Natsuhisa Oka, Junichi Yano

Publikováno v: Bioorganic & Medicinal Chemistry. 16:9154-9160

We have synthesized diastereomerically pure diadenosine 3′,5′-boranophosphates (Ap b A) by using the boranophosphotriester method from ribonucleosides protected with the 2′-hydroxy protecting group 2-cyanoethoxymethyl (CEM). Melting curves of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044560399b26d4023d036da32112614c
https://doi.org/10.1016/j.bmc.2008.09.040

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