Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Junichi Nagakawa"'
Autor:
Shuichi Suzuki, Daisuke Iida, Hironori Fukumoto, Misako Watanabe, Kazuma Takase, Kazuto Yamazaki, Takashi Seiki, Junichi Nagakawa, Mika Aoki, Hiroki Terauchi, Kappei Tsukahara, Takaki Kagaya, Tohru Arai
Publikováno v:
Biomedical Research. 33:337-344
Glucagon-like peptide 2 (GLP-2) is an intestinotropic peptide that binds to GLP-2 receptor (GLP- 2R), a class-B G protein-coupled receptor (GPCR) coupled with Gα(s). Few small-molecule agonists had been reported for class-B GPCRs, but we recently re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6afe4a52cfc5afceb671fc6b861065
https://doi.org/10.2220/biomedres.33.337
https://doi.org/10.2220/biomedres.33.337
Publikováno v:
Japanese Journal of Pharmacology. 76:279-288
The effects of rabeprazole (E3810), omeprazole and chloroquine on hepatic lysosomal function were studied. After chloroquine (50 mg/kg), rabeprazole (5 mg/kg) or omeprazole (5 mg/kg) was given intraperitoneally to rats for 6 days, the bile was collec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642491d1e1d144bda31ae00b3d9881e7
https://doi.org/10.1254/jjp.76.279
https://doi.org/10.1254/jjp.76.279
Autor:
Shuichi Suzuki, Kazuma Takase, Daisuke Iida, Hironori Fukumoto, Kappei Tsukahara, Takaki Kagaya, Hiroki Terauchi, Mika Aoki, Takashi Seiki, Tohru Arai, Junichi Nagakawa, Misako Watanabe, Kazuto Yamazaki
Publikováno v:
Biomedical research (Tokyo, Japan). 34(3)
Glucagon-like peptide 2 (GLP-2) is an intestinotropic peptide that binds to GLP-2 receptor (GLP-2R), a class-B G protein-coupled receptor. The GLP-2R antagonist GLP-2(3-33) has relatively high partial agonistic activity, and there are as yet no ideal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0544787c26e0039d3e327f220ee7fad8
https://pubmed.ncbi.nlm.nih.gov/23782746
https://pubmed.ncbi.nlm.nih.gov/23782746
Autor:
Takaki Kagaya, Misako Watanabe, Junichi Nagakawa, Hironori Fukumoto, Kappei Tsukahara, Koichiro Koyama, Shuichi Suzuki, Kazuto Yamazaki, Mika Aoki, Daisuke Iida, Kazuma Takase, Hiroki Terauchi, Tohru Arai, Takashi Seiki
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(19)
Glucagon-like peptide 2 (GLP-2) is an intestinotropic peptide that binds to GLP-2 receptor (GLP-2R), a class-B G protein-coupled receptor (GPCR). Few synthetic agonists have been reported so far for class-B GPCRs. Here, we report the first scaffold c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633a4500ac37ce8e6b7aa2e11c3b7bf9
https://pubmed.ncbi.nlm.nih.gov/22944117
https://pubmed.ncbi.nlm.nih.gov/22944117
Autor:
Hideo Tonomura, Miwa Jindo, Kotaro Kodama, Misako Watanabe, Junichi Nagakawa, Hideaki Fujisaki, Noriaki Takeguchi
Publikováno v:
Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a spectrum of multifunctional disorder caused by the failure of the normal antireflux mechanism with frequent acid reflux. Patients with GERD experience primary symptoms of heartburn and/or acid regurgitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203ec9946ee53253e82474fc468af39b
http://www.intechopen.com/articles/show/title/e3710-long-acting-ppi-as-new-approach-for-the-treatment-of-unmet-medical-needs-of-gerd
http://www.intechopen.com/articles/show/title/e3710-long-acting-ppi-as-new-approach-for-the-treatment-of-unmet-medical-needs-of-gerd
Autor:
Hiroki Terauchi, Hiroshi Kato, Sou Yasui, Daisuke Iida, Masanobu Shinoda, Yoshikuni Tabata, Kotaro Kodama, Hitoshi Harada, Hiroko Kuramochi, Tetsuya Kawahara, Masato Ueda, Hideaki Fujisaki, Junichi Nagakawa, Kubota Atsuhiko, Miki Murota, Shuhei Miyazawa, Kazuo Hirota, Nobuhisa Watanabe
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 334(2)
We have investigated the pharmacology of sodium (R)-2-[4-(2,2-dimethyl-1,3-dioxan-5-yl) methoxy-3,5-dimethylpyridin-2-yl]methylsulfinyl-1H-benzimidazol (E3710), a new proton pump inhibitor (PPI), and its effect on gastric acid secretion. E3710 irreve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b06d5f878b1b39eab24295f04c7ebd
https://pubmed.ncbi.nlm.nih.gov/20484556
https://pubmed.ncbi.nlm.nih.gov/20484556
Autor:
Isao Yamatsu, Kouichi Katayama, Masahiro Yasuda, Kaname Miyamoto, Takashi Yamanaka, Junichi Nagakawa, Kazuo Hirota, Ieharu Hishinuma
Publikováno v:
Agents and Actions. 37:297-304
E3330 [(2E)-3-[5-(2,3-dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2- propenoic acid], a novel synthesized hepatoprotective compound, has suppressive effects on tumor necrosis factor-alpha (TNF-alpha) generation from monocytes/macrophages in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab2b8c998b2563a1d6c527723de5d55
https://doi.org/10.1007/bf02028123
https://doi.org/10.1007/bf02028123
Autor:
Kaname Miyamoto, Takashi Yamanaka, Kazuo Hirota, Kouichi Katayama, Masahiro Yasuda, Ieharu Hishinuma, Junichi Nagakawa
Publikováno v:
Immunopharmacology and Immunotoxicology. 13:485-498
The possible involvement of interleukin-lα (IL-lα) in the pathogenesis of murine hepatitis model induced with galactosamine and lipopolysaccharide (LPS) was investigated. the injection of 10 ng/mouse of LPS in combination with 10 mg/mouse of galact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a857f669862dcc6b5e3d2573cc162285
https://doi.org/10.3109/08923979109019718
https://doi.org/10.3109/08923979109019718
Autor:
Takashi Yamanaka, Isao Yamatsu, Kazuo Tsukidate, Kaname Miyamoto, Kazuo Hirota, Junichi Nagakawa, Ieharu Hishinuma, Kouichi Katayama
Publikováno v:
Hepatology. 12:1187-1191
Intravenous injection of lipopolysaccharide and D-galactosamine, at doses of 0.2 μg/kg and 800 mg/kg, respectively, elicited massive hepatic necrosis within 24 hr in C3H/HeN mice. The plasma L-alanine aminotransferase (ALT, E.C. 2.6.1.2) or L-aspart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3782494cf0c8788bb336eb403d8f495c
https://doi.org/10.1002/hep.1840120518
https://doi.org/10.1002/hep.1840120518
Autor:
Kazuo Hirota, Kazuo Tsukidate, Takashi Yamanaka, Kouichi Katayama, Kaname Miyamoto, Isao Yamatsu, Ieharu Hishinuma, Junichi Nagakawa
Publikováno v:
Gastroenterology. 99:758-765
The possible involvement of tumor necrosis factor-alpha in the pathogenesis of an experimentally induced hepatitis was investigated. Balb/c mice were primed with Propionibacterium acnes to induce the infiltration of mononuclear cells into the liver.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4d946ec6b91485d82df5a68e87d16e
https://doi.org/10.1016/0016-5085(90)90965-4
https://doi.org/10.1016/0016-5085(90)90965-4