Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Junichi Kushioka"'
Autor:
Masakazu Toya, Junichi Kushioka, Huaishuang Shen, Takeshi Utsunomiya, Hirohito Hirata, Masanori Tsubosaka, Qi Gao, Simon K. Chow, Ning Zhang, Stuart B. Goodman
Publikováno v:
Bone & Joint Research, Vol 13, Iss 1, Pp 28-39 (2024)
Aims: Transcription factor nuclear factor kappa B (NF-κB) plays a major role in the pathogenesis of chronic inflammatory diseases in all organ systems. Despite its importance, NF-κB targeted drug therapy to mitigate chronic inflammation has had lim
Externí odkaz:
https://doaj.org/article/03f1022965b94eff8b11a84c6fa79ee0
Autor:
Junichi Kushioka, Simon Kwoon-Ho Chow, Masakazu Toya, Masanori Tsubosaka, Huaishuang Shen, Qi Gao, Xueping Li, Ning Zhang, Stuart B. Goodman
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-13 (2023)
Abstract Aging of the global population increases the incidence of osteoporosis and associated fragility fractures, significantly impacting patient quality of life and healthcare costs. The acute inflammatory reaction is essential to initiate healing
Externí odkaz:
https://doaj.org/article/492df4d05c164f499f07ee14eaf74a2d
Autor:
Victoria Teissier, Qi Gao, Huaishuang Shen, Jiannan Li, Xueping Li, Elijah Ejun Huang, Junichi Kushioka, Masakazu Toya, Masanori Tsubosaka, Hirohito Hirata, Hossein Vahid Alizadeh, Chima V. Maduka, Christopher H. Contag, Yunzhi Peter Yang, Ning Zhang, Stuart B. Goodman
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Background Continuous cross talk between MSCs and macrophages is integral to acute and chronic inflammation resulting from contaminated polyethylene particles (cPE); however, the effect of this inflammatory microenvironment on mitochondrial
Externí odkaz:
https://doaj.org/article/9eaa6d674cab46c2b7f456805d523a83
Autor:
Xueping Li, Huaishuang Shen, Mao Zhang, Victoria Teissier, Ejun Elijah Huang, Qi Gao, Masanori Tsubosaka, Masakazu Toya, Junichi Kushioka, Chima V. Maduka, Christopher H. Contag, Simon Kwoon-Ho Chow, Ning Zhang, Stuart B. Goodman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundDysregulated inflammation is associated with many skeletal diseases and disorders, such as osteolysis, non-union of fractures, osteonecrosis, osteoarthritis and orthopaedic infections. We previously showed that continuous infusion of lipopo
Externí odkaz:
https://doaj.org/article/3866be4baf1b416a8fb5443f32339990
Autor:
Masakazu Toya, Ning Zhang, Masanori Tsubosaka, Junichi Kushioka, Qi Gao, Xueping Li, Simon Kwoon-Ho Chow, Stuart B. Goodman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Novel minimally invasive strategies are needed to obtain robust bone healing in complex fractures and bone defects in the elderly population. Local cell therapy is one potential option for future treatment. Mesenchymal stromal cells (MSCs) are not on
Externí odkaz:
https://doaj.org/article/d3bdbe354d65433cbe662f853eba4d44
Autor:
Issei Shinohara, Masanori Tsubosaka, Masakazu Toya, Max L. Lee, Junichi Kushioka, Masatoshi Murayama, Qi Gao, Xueping Li, Ning Zhang, Simon Kwoon-Ho Chow, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B. Goodman
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1665 (2023)
Local cell therapy has recently gained attention for the treatment of joint diseases and fractures. Mesenchymal stem cells (MSCs) are not only involved in osteogenesis and angiogenesis, but they also have immunomodulatory functions, such as inducing
Externí odkaz:
https://doaj.org/article/c36a4866e7264b459b7c3f69f7697fa7
Autor:
Shinichi Nakagawa, Rintaro Okada, Junichi Kushioka, Joe Kodama, Hiroyuki Tsukazaki, Zeynep Bal, Daisuke Tateiwa, Yuichiro Ukon, Hiromasa Hirai, Takahiro Makino, Shota Takenaka, Seiji Okada, Takashi Kaito
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The effects and inflammation-related side effects of bone morphogenetic protein (BMP)-2 on posterior lumbar interbody fusion are controversial. One of the potential causes for the inconsistent results is the uncontrolled release of BMP-2 fro
Externí odkaz:
https://doaj.org/article/dc520bc0743741bfb854db9e569f521c
Autor:
Hirohito Hirata, Ning Zhang, Masaya Ueno, Danial Barati, Junichi Kushioka, Huaishuang Shen, Masanori Tsubosaka, Masakazu Toya, Tzuhua Lin, Ejun Huang, Zhenyu Yao, Joy Y. Wu, Stefan Zwingenberger, Fan Yang, Stuart B. Goodman
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background Despite the high incidence of fractures and pseudoarthrosis in the aged population, a potential role for the use of mesenchymal stem cells (MSCs) in the treatment of bone defects in elderly patients has not been elucidated. Inflam
Externí odkaz:
https://doaj.org/article/4e47b8d5e4ec43a6a039cdfb7fe1fce0
Autor:
Joe Kodama, Anjar Anggraini Harumningtyas, Tomoko Ito, Miroslav Michlíček, Satoshi Sugimoto, Hidekazu Kita, Ryota Chijimatsu, Yuichiro Ukon, Junichi Kushioka, Rintaro Okada, Takashi Kamatani, Kunihiko Hashimoto, Daisuke Tateiwa, Hiroyuki Tsukazaki, Shinichi Nakagawa, Shota Takenaka, Takahiro Makino, Yusuke Sakai, David Nečas, Lenka Zajíčková, Satoshi Hamaguchi, Takashi Kaito
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Regeneration of large bone defects caused by trauma or tumor resection remains one of the biggest challenges in orthopedic surgery. Because of the limited availability of autograft material, the use of artificial bone is prevalent; however,
Externí odkaz:
https://doaj.org/article/b20d6767af774235b79c8b38f1f283c1
Autor:
Daisuke Tateiwa, Shinichi Nakagawa, Hiroyuki Tsukazaki, Rintaro Okada, Joe Kodama, Junichi Kushioka, Zeynep Bal, Yuichiro Ukon, Hiromasa Hirai, Takashi Kaito
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Although bone morphogenetic protein (BMP) has potent osteoinductivity, the potential adverse events attributed to its burst release prevent its widespread clinical application. Therefore, there is a strong need for BMP delivery systems that
Externí odkaz:
https://doaj.org/article/3d434f4005814c69917236e42c7b0c5c