Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Junichi Enokizono"'
Publikováno v:
Drug Metabolism and Disposition. 51:338-347
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f1fb87e5ccc45b4cc573db99e6abaad
https://doi.org/10.1124/dmd.122.001098
https://doi.org/10.1124/dmd.122.001098
Autor:
Daisuke Shinmi, Ryosuke Nakano, Keisuke Mitamura, Minami Suzuki‐Imaizumi, Junko Iwano, Yuya Isoda, Junichi Enokizono, Yasuhisa Shiraishi, Emi Arakawa, Kazuma Tomizuka, Kazuhiro Masuda
Publikováno v:
Cancer Medicine, Vol 6, Iss 4, Pp 798-808 (2017)
Abstract Carcinoembryonic antigen (CEA) is a classic tumor‐specific antigen that is overexpressed in several cancers, including gastric cancer. Although some anti‐CEA antibodies have been tested, to the best of our knowledge, there are currently
Externí odkaz:
https://doaj.org/article/bb89aaf8f1514e1dadc670cc4bef52df
Autor:
Norie Shimai, Akihiro Tokunaga, Tomoyuki Naoi, Hayato Yabuuchi, Eri Taguchi, Junichi Enokizono, Maki Hasegawa, Toshihiko Ishii, Kohei Kubota, Yumi Sasayama, Takeshi Kuboyama, Miyoko Asano
Publikováno v:
Journal of Controlled Release. :245-256
We developed a lipid nanoparticle formulation (LNPK15) to deliver siRNA to a tumor for target gene knock down. LNPK15 is highly PEGylated with 3.3% 1,2-distearoyl-sn-glycero-3-phosphatidylethanolamine-N-(polyethylene glycol-2000) (PEG-DSPE) and shows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e375b08aa99eae41ebfcfa91715dd17
https://doi.org/10.1016/j.jconrel.2019.09.004
https://doi.org/10.1016/j.jconrel.2019.09.004
Publikováno v:
Drug Metabolism and Disposition. 47:1240-1246
Carcinoembryonic antigen (CEA) is a tumor-specific antigen overexpressed in multiple cancers. CEA is expressed as a membrane protein, a part of which is cleaved from the cell membrane and secreted into blood. The soluble form of CEA (sCEA) has been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2ba709a577de57ba49c0194b98364c
https://doi.org/10.1124/dmd.119.088179
https://doi.org/10.1124/dmd.119.088179
Autor:
Shota Warashina, Nobuhiro Yagi, Kazuya Narushima, Maiko Takahashi, Junko Iwano, Yasuhiro Wada, Hayato Yabuuchi, Takeshi Kuboyama, Yasuyoshi Watanabe, Kentaro Hatanaka, Maki Zouda, Junichi Enokizono, Hidefumi Mukai
Publikováno v:
Journal of Controlled Release. 294:185-194
In vivo biodistribution analyses, especially in tumors, of nucleic acids delivered with nanoparticles are important to develop drug delivery technologies for medical use. We previously developed wrapsome® (WS), an ~100 nm liposomal nanoparticle that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f63d875ab3d2581529d36544107a8fd
https://doi.org/10.1016/j.jconrel.2018.12.006
https://doi.org/10.1016/j.jconrel.2018.12.006
Autor:
Kazuma Tomizuka, Aiko Uchida, Junichi Enokizono, Yasuhisa Shiraishi, Yuya Isoda, Eri Taguchi, Kiyomi Yoshikawa, Junko Iwano, Shigeki Takaoka, Wen Piao, Emi Arakawa, Kazuhiro Masuda
Publikováno v:
Oncotarget
Photodynamic therapy (PDT) utilize a photosensitizing agent and light for cancer therapy. It exerts anti-cancer effect mainly by inducing vascular occlusion at the irradiated site. By controlling the irradiation area, PDT can be used in a tumor-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6693300c1db9a5fbe52012bb3f4dd3
https://doi.org/10.18632/oncotarget.25831
https://doi.org/10.18632/oncotarget.25831
Autor:
Junichi Enokizono, Emi Arakawa, Ryosuke Nakano, Junko Iwano, Kazuhiro Masuda, Daisuke Shinmi, Keisuke Mitamura, Yuya Isoda, Minami Suzuki-Imaizumi, Yasuhisa Shiraishi, Kazuma Tomizuka
Publikováno v:
Cancer Medicine
Carcinoembryonic antigen (CEA) is a classic tumor‐specific antigen that is overexpressed in several cancers, including gastric cancer. Although some anti‐CEA antibodies have been tested, to the best of our knowledge, there are currently no clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4eaa0744279dacecdf06e50d6ad7ca
https://pubmed.ncbi.nlm.nih.gov/28211613
https://pubmed.ncbi.nlm.nih.gov/28211613
Autor:
Yasuhisa Shiraishi, Junko Iwano, Daisuke Shinmi, Kazuhiro Masuda, Tsuyoshi Yamaguchi, Junichi Enokizono, Eri Taguchi
Publikováno v:
Bioconjugate chemistry. 27(5)
Engineered cysteine residues are particularly convenient for site-specific conjugation of antibody-drug conjugates (ADC), because no cell engineering and additives are required. Usually, unpaired cysteine residues form mixed disulfides during ferment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e6d554a19e1bb2cc6bf3372dfefb7a
https://pubmed.ncbi.nlm.nih.gov/27074832
https://pubmed.ncbi.nlm.nih.gov/27074832
Autor:
Junichi Enokizono
Publikováno v:
Folia Pharmacologica Japonica. 134:78-81
薬物の多くは，血漿中でアルブミンやα1-酸性糖タンパクなどのタンパク質へ結合している．アルブミンは脂溶性の高い酸性化合物，α1-酸性糖タンパクは塩基性化合物に対し高い親和性
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492f5c593a980bd9cfa4e79678ae51b1
https://doi.org/10.1254/fpj.134.78
https://doi.org/10.1254/fpj.134.78
Publikováno v:
Drug Metabolism and Disposition. 36:995-1002
The role of breast cancer resistance protein (BCRP/ABCG2) in limiting the brain and testis penetration of xenobiotic compounds in the blood-brain and -testis barriers was investigated using Bcrp(-/-) mice. Tissue/plasma concentration ratios in the br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb3a71a704ddac72e7742afa57d943c
https://doi.org/10.1124/dmd.107.019257
https://doi.org/10.1124/dmd.107.019257