Thyroid hormone protects human lung epithelial cells from cold preservation and warm reperfusion-induced injury

Autor: Dejan Bojic, Tanroop Aujla, Junichi Sugihara, Aaron Wong, Shaf Keshavjee, Mingyao Liu

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)

Abstract Background Cellular stress associated with static-cold storage (SCS) and warm reperfusion of donor lungs can contribute to ischemia–reperfusion (IR) injury during transplantation. Adding cytoprotective agents to the preservation solution m

Externí odkaz: https://doaj.org/article/8ed0a47679e54bb49fd99fb6c471c0ec

Ischemia-Reperfusion Injury in a Simulated Lung Transplant Setting Differentially Regulates Transcriptomic Profiles between Human Lung Endothelial and Epithelial Cells

Autor: Gaowa Saren, Aaron Wong, Yun-Bi Lu, Cristina Baciu, Wenyong Zhou, Ricardo Zamel, Sahar Soltanieh, Junichi Sugihara, Mingyao Liu

Publikováno v: Cells, Vol 10, Iss 10, p 2713 (2021)

Current understanding of mechanisms of ischemia-reperfusion-induced lung injury during lung preservation and transplantation is mainly based on clinical observations and animal studies. Herein, we used cell and systems biology approaches to explore t

Externí odkaz: https://doaj.org/article/4be11fc175e44188a3a354569d3e788a

XB130 Plays an Essential Role in Folliculogenesis Through Mediating Interactions Between Microfilament and Microtubule Systems in Thyrocytes

Autor: Junichi Sugihara, Peter Arvan, Mingyao Liu, Samuel Refetoff, Yingchun Wang, Wei-Yang Lu, Yun-Yan Xiang, Xiao Hui Liao

Publikováno v: Thyroid

Background: XB130 (actin filament-associated protein 1-like 2, AFAP1L2) is a thyroid-abundant adaptor/scaffold protein. Xb130(−/−) mice exhibit transient growth retardation postnatally due to congenital hypothyroidism with diminished thyroglobuli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd34d94abb33955d0e6cd45a2f15cf75
https://pubmed.ncbi.nlm.nih.gov/34652970

Arg302 governs the pK a of Glu325 in LacY

Autor: H. Ronald Kaback, Junichi Sugihara, Ana Filipa Santos Seica, Petra Hellwig, Natalia Grytsyk

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (11), pp.4934-4939. ⟨10.1073/pnas.1820744116⟩

Significance The alkaline pK for galactoside binding by the lactose permease of Escherichia coli correlates precisely with the pK a of Glu325, as determined by reaction-induced surface-enhanced infrared absorption spectroscopy (SEIRAS). Glu325 must b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc2fba7852c204111a814557c212a12
https://doi.org/10.1073/pnas.1820744116

L-alanyl-L-glutamine Improves Lung Performance during Ex Vivo Lung Perfusion: From Cellular Mechanism to Porcine Donor Lungs

Autor: Shaf Keshavjee, A. Gower, L. Jing, S. Soltanieh, X. Gao, Ravi N. Vellanki, Bradly G. Wouters, Xiao-Hui Bai, L. Huang, Marcelo Cypel, Junichi Sugihara, Mingyao Liu

Publikováno v: The Journal of Heart and Lung Transplantation. 39:S197-S198

Purpose Ex vivo lung perfusion (EVLP) is an established technology to assess marginal donor lungs. EVLP application has increased the use of donor lungs and is being further developed as a platform for the repair of lung injury. Steen solution is one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::127804ba3a7427c622b9f86621e93289
https://doi.org/10.1016/j.healun.2020.01.800