Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Junichi, Ishiyama"'
Autor:
Minoru Ito, Michiaki Nagasawa, Naoki Omae, Masaki Tsunoda, Junichi Ishiyama, Tomohiro Ide, Yunike Akasaka, Koji Murakami
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 6, Pp 1531-1540 (2013)
Insulin plays important roles in apoptosis and lipid droplet (LD) formation, and it is one of the determinants involved in increasing fat mass. However, the mechanisms underlying insulin-induced enlargement of fat mass remain unclear. Our previous st
Externí odkaz:
https://doaj.org/article/bcf99b2cc6744823b0f6b09daacc0bdf
Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages
Autor:
Junichi Ishiyama, Ryoko Taguchi, Yunike Akasaka, Saiko Shibata, Minoru Ito, Michiaki Nagasawa, Koji Murakami
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 2, Pp 299-307 (2011)
Palmitic acid (PA) upregulates oxidized LDL receptor-1 (LOX-1), a scavenger receptor responsible for uptake of oxidized LDL (oxLDL), and enhances oxLDL uptake in macrophages. However, the precise underlying mechanism remains to be elucidated. PA is k
Externí odkaz:
https://doaj.org/article/47b4374b2ffe48e289257e55509725a7
Autor:
John A. Lupisella, Kiyoshi Fujii, David A. Gordon, Mei-Yin Hsu, Toshikazu Yamaoka, Yasuchi Kohno, Kohei Ohata, Kosuke Tsuda, Kazuto Arakawa, Nancy L. Carson, Kazunori Fukuchi, Ruth R. Wexler, Francisco Villarreal, Ellen K. Kick, Junichi Ishiyama, Jacek Ostrowski, Shingo Matsushima, Hitomi Yamada, Yoshifumi Saito, Bruce R. Ito, Yoshikazu Asahina, Ricardo Garcia, Nicholas R. Wurtz
Publikováno v:
Journal of medicinal chemistry. 63(17)
Formyl peptide receptor 2 (FPR2) agonists can stimulate resolution of inflammation and may have utility for treatment of diseases caused by chronic inflammation, including heart failure. We report the discovery of a potent and selective FPR2 agonist
Autor:
Shingo Matsushima, Junichi Ishiyama
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 311:L1050-L1061
MicroRNAs play an important role in the development and progression of various diseases, such as idiopathic pulmonary fibrosis (IPF). Although the accumulation of aberrant fibroblasts resistant to apoptosis is a hallmark in IPF lungs, the mechanism r
Autor:
Koji Murakami, Junichi Ishiyama, Minoru Ito, Tomohiro Ide, Naoki Omae, Masaki Tsunoda, Michiaki Nagasawa, Yunike Akasaka
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 6, Pp 1531-1540 (2013)
Insulin plays important roles in apoptosis and lipid droplet (LD) formation, and it is one of the determinants involved in increasing fat mass. However, the mechanisms underlying insulin-induced enlargement of fat mass remain unclear. Our previous st
Autor:
Allister Fraser, Kevin R. Shreder, Junichi Ishiyama, John W. Kozarich, Yi Hu, Yasushi Kohno, Heidi E. Brown, Lingling Du, Eric Okerberg, Christopher M. Amantea, Julia Cajica, Emme C.K. Lin, Lan M. Pham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1553-1556
AX10479, the phenyl amide of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid, was identified as a Zn2+-dependent, 27 nM inhibitor of human plasma Lp-PLA2. Structure–activity relationship studies focused on the AX10479 2-phenylamide gro
Autor:
Helge Weissig, Shyama Sidique, John W. Kozarich, Emme C.K. Lin, Tyzoon K. Nomanbhoy, Jonathan S. Rosenblum, Junichi Ishiyama, Yi Hu, Bei Li, Christopher M. Amantea
Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain. Genetic deletion of ERK5 is embryonic lethal, and tissue-restricted dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa0e539b27866c3e1d8419d25b4f8e3
https://europepmc.org/articles/PMC5081620/
https://europepmc.org/articles/PMC5081620/
Autor:
Helge Weissig, Bei Li, Junichi Ishiyama, Yi Hu, Shyama Sidique, Tyzoon K. Nomanbhoy, Jonathan S. Rosenblum, Emme C.K. Lin, Christopher A. Amantea, John W. Kozarich
Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain. Genetic deletion of ERK5 is embryonic lethal and tissue-restricted delet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb49cdb1aa5edb36cb53312a114b6d1f
https://doi.org/10.1101/038513
https://doi.org/10.1101/038513
Autor:
Eric Okerberg, Julia Cajica, Kevin R. Shreder, Yasushi Kohno, Lan M. Pham, Heidi E. Brown, Junichi Ishiyama, Yi Hu, John W. Kozarich, Allister Fraser, Lingling Du, Emme C.K. Lin, Christopher M. Amantea
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:868-871
AX10185, the phenyl amide of xanthurenic acid, was found to be a sub-100 nM inhibitor of Lp-PLA2. However, in the presence of EDTA the inhibitory activity of AX10185 was extinguished while the enzymatic activity of Lp-PLA2 did not change. Subsequent
Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages
Autor:
Yunike Akasaka, Saiko Shibata, Minoru Ito, Michiaki Nagasawa, Koji Murakami, Ryoko Taguchi, Junichi Ishiyama
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 2, Pp 299-307 (2011)
Journal of Lipid Research
Journal of Lipid Research
Palmitic acid (PA) upregulates oxidized LDL receptor-1 (LOX-1), a scavenger receptor responsible for uptake of oxidized LDL (oxLDL), and enhances oxLDL uptake in macrophages. However, the precise underlying mechanism remains to be elucidated. PA is k