Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Junhui Zhen"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundMinimal change disease (MCD) is a common cause of adult nephrotic syndrome. Most adults with MCD achieve complete remission (CR) after initial steroid therapy. However, approximately 30% of adults who respond to steroids experience frequent
Externí odkaz:
https://doaj.org/article/975fc8cfae8e47769ff62a5f724402f7
Publikováno v:
Chronic Diseases and Translational Medicine, Vol 9, Iss 4, Pp 345-348 (2023)
Externí odkaz:
https://doaj.org/article/342098f16f4649adb5cbcf4c573d34b9
Autor:
Yang Zhang, Yujie Yang, Fan Yang, Xiaohan Liu, Ping Zhan, Jichao Wu, Xiaojie Wang, Ziying Wang, Wei Tang, Yu Sun, Yan Zhang, Qianqian Xu, Jin Shang, Junhui Zhen, Min Liu, Fan Yi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Renal tubular epithelial cells (TECs) play a key role in kidney fibrosis by mediating cycle arrest at G2/M. However, the key HDAC isoforms and the underlying mechanism that are involved in G2/M arrest of TECs remain unclear. Here, we find th
Externí odkaz:
https://doaj.org/article/11ae85f9158f47a3ae1c1d0040c59134
Autor:
Jinxiu Hu, Qimeng Wang, Xiaoting Fan, Junhui Zhen, Cheng Wang, Huimin Chen, Yingxiao Liu, Ping Zhou, Tingwei Zhang, Tongtong Huang, Rong Wang, Zhimei Lv
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-16 (2023)
Abstract Dysfunction of podocytes has been regarded as an important early pathologic characteristic of diabetic kidney disease (DKD), but the regulatory role of long noncoding RNAs (lncRNAs) in this process remains largely unknown. Here, we performed
Externí odkaz:
https://doaj.org/article/1931bd53e71941849b7f8b7d47de7170
Autor:
Yanfang Zhao, Xiaoting Fan, Qimeng Wang, Junhui Zhen, Xia Li, Ping Zhou, Yating Lang, Qinghao Sheng, Tingwei Zhang, Tongtong Huang, Yucheng Zhao, Zhimei Lv, Rong Wang
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102674- (2023)
Renal fibrosis is the common histopathological feature of chronic kidney diseases (CKD), and there is increasing evidence that epigenetic regulation is involved in the occurrence and progression of renal fibrosis. N-myc downstream-regulated gene 2 (N
Externí odkaz:
https://doaj.org/article/415a9ad0fd924996b7d94af64db16132
Autor:
Ziyang Wang, Ying Chang, Yue Liu, Bing Liu, Junhui Zhen, Xiaobing Li, Jiangong Lin, Qun Yu, Zhimei Lv, Rong Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 136-153 (2022)
Podocyte damage is strongly associated with the progression of diabetic nephropathy. Mitotic catastrophe plays an essential role in accelerating podocyte loss and detachment from the glomerular basement membrane. In the current study, we observed tha
Externí odkaz:
https://doaj.org/article/ac98c5c0eaff444d9e2b55ad3a56fcfb
Autor:
Jinxiu Hu, Jiao Qiao, Qun Yu, Bing Liu, Junhui Zhen, Yue Liu, Qiqi Ma, Yanmei Li, Qianhui Wang, Cheng Wang, Zhimei Lv
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Background Acute kidney injury (AKI), with a high morbidity and mortality, is recognized as a risk factor for chronic kidney disease (CKD). AKI-CKD transition has been regarded as one of the most pressing unmet needs in renal diseases. Recen
Externí odkaz:
https://doaj.org/article/e8c198a2da714906b70f096082a85303
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mitochondrial injury of tubular epithelial cells (TECs) is the key pathogenic event underlying various kidney diseases and a potential intervening target as well. Our previous study demonstrated that ING2 is ubiquitously expressed at tubulointerstiti
Externí odkaz:
https://doaj.org/article/16593aaf5d5a4037820ec8448f0d486a
Autor:
Zhao Wang, Yuxin Xu, Linbo Tian, Qingjin Chi, Fengrong Zhao, Rongqi Xu, Guilei Jin, Yansong Liu, Junhui Zhen, Sasa Zhang
Publikováno v:
Diagnostics, Vol 12, Iss 8, p 1849 (2022)
Targeted therapy is an effective treatment for non-small cell lung cancer. Before treatment, pathologists need to confirm tumor morphology and type, which is time-consuming and highly repetitive. In this study, we propose a multi-task deep learning m
Externí odkaz:
https://doaj.org/article/304b71dedc094e8ebb479e11a18a1c1a
SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101428- (2020)
Summary: Mitochondrial DNA (mtDNA) encodes thirteen core components of OXPHOS complexes, and its steady expression is crucial for cellular energy homeostasis. However, the regulation of mtDNA expression machinery, along with its sensing mechanism to
Externí odkaz:
https://doaj.org/article/e2e952833dd942dcb82f2155a60a66c8