Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Junhai Xiao"'
Autor:
Pengyun Li, Xiaotong Hu, Zhiya Fan, Shiyang Sun, Qijie Ran, Ting Wei, Pengli Wei, Qiyu Jiang, Jian Yan, Ning Yang, Changkai Jia, Tingting Yang, Yaqiu Mao, Xu Cai, Tingting Xu, Zhiyuan Zhao, Xiaohong Qian, Weijie Qin, Xiaomei Zhuang, Feng Fan, Junhai Xiao, Zhibing Zheng, Song Li
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-30 (2024)
Abstract Background Targeted protein degradation of neosubstrates plays a crucial role in hematological cancer treatment involving immunomodulatory imide drugs (IMiDs) therapy. Nevertheless, the persistence of inevitable drug resistance and hematolog
Externí odkaz:
https://doaj.org/article/53485170677d439b9bf56471960e9a2e
Autor:
Pengyun Li, Changkai Jia, Zhiya Fan, Xiaotong Hu, Wenjuan Zhang, Ke Liu, Shiyang Sun, Haoxin Guo, Ning Yang, Maoxiang Zhu, Xiaomei Zhuang, Junhai Xiao, Zhibing Zheng, Song Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 6, Pp 2715-2735 (2023)
Various c-mesenchymal-to-epithelial transition (c-MET) inhibitors are effective in the treatment of non-small cell lung cancer; however, the inevitable drug resistance remains a challenge, limiting their clinical efficacy. Therefore, novel strategies
Externí odkaz:
https://doaj.org/article/a6801985536042d3a2e104c93c866c0d
Publikováno v:
Molecules, Vol 29, Iss 10, p 2211 (2024)
Due to the resistance of Gram-negative bacteria Pseudomonas aeruginosa PAO1 to most clinically relevant antimicrobials, the use of traditional antibiotic treatments in hospitals is challenging. The formation of biofilms, which is regulated by the quo
Externí odkaz:
https://doaj.org/article/0edba6ba07134b749f0f4a36314ef1af
Autor:
Qianqian Shi, Huiqi Wen, Yijie Xu, Xu Zhao, Jing Zhang, Ye Li, Qingbin Meng, Fang Yu, Junhai Xiao, Xingzhou Li
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Introduction: Quorum sensing (QS) is a bacterial intracellular and intercellular communication system that regulates virulence factor production, biofilm formation, and antibiotic sensitivity. Quorum-sensing inhibitors (QSIs) are a novel class of ant
Externí odkaz:
https://doaj.org/article/6d67397a389348c1bfb949a1601db033
Autor:
Yijie Xu, Chunlan Zeng, Huiqi Wen, Qianqian Shi, Xu Zhao, Qingbin Meng, Xingzhou Li, Junhai Xiao
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 737 (2023)
Quorum sensing (QS) is a cell-to-cell communication mechanism that regulates bacterial pathogenicity, biofilm formation, and antibiotic sensitivity. Among the identified quorum sensing, AI-2 QS exists in both Gram-negative and Gram-positive bacteria
Externí odkaz:
https://doaj.org/article/e5f3a2f0ae4a48e6b974fce27ba5882d
Publikováno v:
Molecules, Vol 28, Iss 7, p 2906 (2023)
The stimulator-of-interferon-gene (STING) protein is involved in innate immunity. The drug DMXAA (5,6-dimethylxanthenone-4-acetic acid) proved to be a potent murine-STING (mSTING) agonist but had little effect on human-STING (hSTING). In this paper,
Externí odkaz:
https://doaj.org/article/a642f340b6214e62817955b40fcc032b
Autor:
Kai Jiang, Yijie Xu, Bo Yuan, Yuandong Yue, Meihua Zhao, Rui Luo, Hao Wu, Lei Wang, Yuanyuan Zhang, Junhai Xiao, Feng Lin
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Bacterial drug resistance caused by overuse and misuse of antibiotics is common, especially in clinical multispecies infections. It is of great significance to discover novel agents to treat clinical bacterial infections. Studies have demonstrated th
Externí odkaz:
https://doaj.org/article/0e4f12e4224b4abfa58380f10a0973e9
Publikováno v:
Molecules, Vol 27, Iss 10, p 3335 (2022)
Hydroxamate, as a zinc-binding group (ZBG), prevails in the design of histone deacetylase 6(HDAC6) inhibitors due to its remarkable zinc-chelating capability. However, hydroxamate-associated genotoxicity and mutagenicity have limited the widespread a
Externí odkaz:
https://doaj.org/article/f2c2ddc6a4c34e87b1607addebf4260b
Autor:
Hongquan Zhang, Chunxi Wen, Bingting Li, Xinlin Yan, Yangrong Xu, Jialin Guo, Shi Hou, Jiajia Chang, Song Li, Junhai Xiao
Publikováno v:
Molecules, Vol 27, Iss 8, p 2428 (2022)
Radiotherapy is a vital approach for brain tumor treatment. The standard treatment for glioblastoma (GB) is maximal surgical resection combined with radiotherapy and chemotherapy. However, the non-sensitivity of tumor cells in the hypoxic area of sol
Externí odkaz:
https://doaj.org/article/adf07cec77234590923700064bdc7caa
Autor:
Libao Xu, Yang Zhang, Wenjie Dai, Ying Wang, Dan Jiang, Lili Wang, Junhai Xiao, Xiaohong Yang, Song Li
Publikováno v:
Molecules, Vol 19, Iss 3, Pp 3539-3551 (2014)
The design, synthesis and structure-activity relationship studies of some novel trisubstituted pyrimidine amide derivatives prepared as CCR4 antagonists are described. The activities of these compounds were evaluated by the CCR4-MDC chemotaxis inhibi
Externí odkaz:
https://doaj.org/article/a0275585939f4778b255f39fb7db2055