Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Jungsan, Sohn"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract cGAS activates innate immune responses against cytosolic double-stranded DNA. Here, by determining crystal structures of cGAS at various reaction stages, we report a unifying catalytic mechanism. apo-cGAS assumes an array of inactive conform
Externí odkaz:
https://doaj.org/article/c60f0c63974344418747e02f012b8014
Autor:
Shuai Wu, Archit Garg, Zachary Mazanek, Gretchen Belotte, Jeffery J Zhou, Christina M Stallings, Jacob Lueck, Aubrey Roland, Michael A Chattergoon, Jungsan Sohn
Publikováno v:
eLife, Vol 13 (2024)
Inflammasomes are filamentous signaling platforms essential for host defense against various intracellular calamities such as pathogen invasion and genotoxic stresses. However, dysregulated inflammasomes cause an array of human diseases including aut
Externí odkaz:
https://doaj.org/article/7d9bf18aaa8f48739b5717b8995d9018
Autor:
Mariusz Matyszewski, Weili Zheng, Jacob Lueck, Zachary Mazanek, Naveen Mohideen, Albert Y. Lau, Edward H. Egelman, Jungsan Sohn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
AIM2-ASC inflammasomes are filamentous signalling platforms that play a central role in host innate defence. Here, the authors present the filament cryo-EM structure of the inflammasome receptor AIM2, which is very similar to the adaptor ASC filament
Externí odkaz:
https://doaj.org/article/e9f87d25b7154a22a54ca96eb6816da0
Autor:
Brendan Antiochos, Daniela Trejo-Zambrano, Paride Fenaroli, Avi Rosenberg, Alan Baer, Archit Garg, Jungsan Sohn, Jessica Li, Michelle Petri, Daniel W Goldman, Christopher Mecoli, Livia Casciola-Rosen, Antony Rosen
Publikováno v:
eLife, Vol 11 (2022)
Background: Nucleic acid binding proteins are frequently targeted as autoantigens in systemic lupus erythematosus (SLE) and other interferon (IFN)-linked rheumatic diseases. The AIM-like receptors (ALRs) are IFN-inducible innate sensors that form sup
Externí odkaz:
https://doaj.org/article/4190c93887f34785aebea47cdf1069aa
Publikováno v:
Nucleic Acids Research. 51:2574-2585
Upon sensing cytosolic- and/or viral double-stranded (ds)DNA, absent-in-melanoma-2 (AIM2)-like-receptors (ALRs) assemble into filamentous signaling platforms to initiate inflammatory responses. The versatile yet critical roles of ALRs in host innate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae6495134cd81fd2f45269fa3f3294b6
https://doi.org/10.1093/nar/gkad090
https://doi.org/10.1093/nar/gkad090
Autor:
Richard M Hooy, Jungsan Sohn
Publikováno v:
eLife, Vol 7 (2018)
Cyclic G/AMP synthase (cGAS) initiates type-1 interferon responses against cytosolic double-stranded (ds)DNA, which range from antiviral gene expression to apoptosis. The mechanism by which cGAS shapes this diverse signaling landscape remains poorly
Externí odkaz:
https://doaj.org/article/f5d15df6b52c4f2d908057af9ec61efa
Autor:
Jungsan Sohn
Publikováno v:
Molecular Cell. 83:502-503
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fd658660b0fbb45380cde4ed746e50e
https://doi.org/10.1016/j.molcel.2023.01.021
https://doi.org/10.1016/j.molcel.2023.01.021
Autor:
Zachary Mazanek, Shuai Wu, Gretchen Belotte, Jeffery J. Zhou, Christina M. Stallings, Archit Garg, Jacob Lueck, Jungsan Sohn
Inflammasomes are filamentous signaling platforms essential for host defense against various intracellular calamities such as pathogen invasion and genotoxic stresses. However, dysregulated inflammasomes cause an array of human diseases including aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c8f4125023043cbd030086505b0c37e
https://doi.org/10.1101/2022.08.02.502519
https://doi.org/10.1101/2022.08.02.502519
