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Abstract 933: Modeling acquired resistance to EGFR-directed therapies in mouse models of lung cancer
Autor:
Katerina Politi, William Pao, Zhongming Zhao, Jungfeng Xia, Valentina Pirazzoli, Elisa de Stanchina
Publikováno v:
Cancer Research. 73:933-933
Seventy percent of patients with Epidermal Growth Factor Receptor (EGFR) mutant lung cancer respond to treatment with the tyrosine kinase inhibitors (TKIs) erlotinib or gefitinib. Despite this high response rate, patients almost inevitably develop re