Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Jung-Ying Tzeng"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1010597 (2023)
Polygenic risk score (PRS) is a quantity that aggregates the effects of variants across the genome and estimates an individual's genetic predisposition for a given trait. PRS analysis typically contains two input data sets: base data for effect size
Externí odkaz:
https://doaj.org/article/4db4ebd25b214cdbb5eee2485837d56a
Autor:
Kaylyn Clark, Wei Fu, Chia-Lun Liu, Pei-Chuan Ho, Hui Wang, Wan-Ping Lee, Shin-Yi Chou, Li-San Wang, Jung-Ying Tzeng
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
To better capture the polygenic architecture of Alzheimer’s disease (AD), we developed a joint genetic score, MetaGRS. We incorporated genetic variants for AD and 24 other traits from two independent cohorts, NACC (n = 3,174, training set) and UPit
Externí odkaz:
https://doaj.org/article/49e6b655ea86473b9bfed9462e076da4
Autor:
Caizhi Huang, Benjamin J. Callahan, Michael C. Wu, Shannon T. Holloway, Hayden Brochu, Wenbin Lu, Xinxia Peng, Jung-Ying Tzeng
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Background The relationship between host conditions and microbiome profiles, typically characterized by operational taxonomic units (OTUs), contains important information about the microbial role in human health. Traditional association test
Externí odkaz:
https://doaj.org/article/bce6dd4844de483fac6372681157b1d2
Autor:
Jocelyn T. Chi, Ilse C. F. Ipsen, Tzu-Hung Hsiao, Ching-Heng Lin, Li-San Wang, Wan-Ping Lee, Tzu-Pin Lu, Jung-Ying Tzeng
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The explosion of biobank data offers unprecedented opportunities for gene-environment interaction (GxE) studies of complex diseases because of the large sample sizes and the rich collection in genetic and non-genetic information. However, the extreme
Externí odkaz:
https://doaj.org/article/e4bb29e559ea451c939fac65c1eff942
Autor:
Wan-Ping Lee, Albert A. Tucci, Mitchell Conery, Yuk Yee Leung, Amanda B. Kuzma, Otto Valladares, Yi-Fan Chou, Wenbin Lu, Li-San Wang, Gerard D. Schellenberg, Jung-Ying Tzeng
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Alzheimer’s Disease (AD) is a progressive neurologic disease and the most common form of dementia. While the causes of AD are not completely understood, genetics plays a key role in the etiology of AD, and thus finding genetic factors holds the pot
Externí odkaz:
https://doaj.org/article/631c6e2012e64644aa1bb9fe8e8e33d6
Autor:
Qi-You Yu, Tzu-Pin Lu, Tzu-Hung Hsiao, Ching-Heng Lin, Chi-Yun Wu, Jung-Ying Tzeng, Chuhsing Kate Hsiao
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Genomic studies have been a major approach to elucidating disease etiology and to exploring potential targets for treatments of many complex diseases. Statistical analyses in these studies often face the challenges of multiplicity, weak signals, and
Externí odkaz:
https://doaj.org/article/26dec9d359274d64b573f8c6a9638280
Autor:
Amanda Brucker, Wenbin Lu, Rachel Marceau West, Qi-You Yu, Chuhsing Kate Hsiao, Tzu-Hung Hsiao, Ching-Heng Lin, Patrik K E Magnusson, Patrick F Sullivan, Jin P Szatkiewicz, Tzu-Pin Lu, Jung-Ying Tzeng
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007797 (2020)
Copy number variants (CNVs) are the gain or loss of DNA segments in the genome that can vary in dosage and length. CNVs comprise a large proportion of variation in human genomes and impact health conditions. To detect rare CNV associations, kernel-ba
Externí odkaz:
https://doaj.org/article/88a8bc6a56c04085b78960c936494bce
Autor:
Sheng-Mao Chang, Hui-Ju Tsai, Jung-Ying Tzeng, Kuo-Wei Yeh, Li-Chen Chen, Shen-Hao Lai, Sui-Ling Liao, Man-Chin Hua, Ming-Han Tsai, Jing-Long Huang, Tsung-Chieh Yao
Publikováno v:
World Allergy Organization Journal, Vol 12, Iss 11, Pp - (2019)
Background and objective: This study aimed to establish reference equations for spirometry in healthy Taiwanese children and assess the applicability of the Global Lung Function Initiative (GLI)-2012 equations to Taiwanese children. Methods: Spiromet
Externí odkaz:
https://doaj.org/article/c61025ee14b54d59a1613b6c27f5de95
Autor:
Yiwen Luo, Lauren E. McCullough, Jung-Ying Tzeng, Thomas Darrah, Avner Vengosh, Rachel L. Maguire, Arnab Maity, Carmen Samuel-Hodge, Susan K. Murphy, Michelle A. Mendez, Cathrine Hoyo
Publikováno v:
BMC Public Health, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background Cadmium (Cd), lead (Pb) and arsenic (As) are common environmental contaminants that have been associated with lower birthweight. Although some essential metals may mitigate exposure, data are inconsistent. This study sought to eva
Externí odkaz:
https://doaj.org/article/3cd95f49ed1e40788ecd169601069487
Autor:
Rachel Marceau West, Wenbin Lu, Daniel M Rotroff, Melaine A Kuenemann, Sheng-Mao Chang, Michael C Wu, Michael J Wagner, John B Buse, Alison A Motsinger-Reif, Denis Fourches, Jung-Ying Tzeng
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 2, p e1006722 (2019)
Rare variants are of increasing interest to genetic association studies because of their etiological contributions to human complex diseases. Due to the rarity of the mutant events, rare variants are routinely analyzed on an aggregate level. While ag
Externí odkaz:
https://doaj.org/article/cfa869d9762a4af085de4661762e40ed