Výsledky vyhledávání - "Jung-Jin Park"

Akademický článek

Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema

Autor: Jung-Jin Park, Kwangseok Oh, Gun-Wu Lee, Geul Bang, Jin-Hee Park, Han-Byeol Kim, Jin Young Kim, Eun-Young Shin, Eung-Gook Kim

Publikováno v: Experimental and Molecular Medicine, Vol 55, Iss 4, Pp 794-805 (2023)

Abstract Senescence, a hallmark of aging, is a factor in age-related diseases (ARDs). Therefore, targeting senescence is widely regarded as a practicable method for modulating the effects of aging and ARDs. Here, we report the identification of regor

Externí odkaz: https://doaj.org/article/596467903462476eabef0d4df5a126ae

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Akademický článek

p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1

Autor: So-Yoon Won, Jung-Jin Park, Soon-Tae You, Jong-A Hyeun, Hyong-Kyu Kim, Byung Kwan Jin, Catriona McLean, Eun-Young Shin, Eung-Gook Kim

Publikováno v: Cell Death and Disease, Vol 13, Iss 6, Pp 1-13 (2022)

Abstract Aggregation of misfolded alpha-synuclein (α-synuclein) is a central player in the pathogenesis of neurodegenerative diseases. Therefore, the regulatory mechanism underlying α-synuclein aggregation has been intensively studied in Parkinson�

Externí odkaz: https://doaj.org/article/ea5257c7141342b589cea8d0d933be1d

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Akademický článek

PAK4 signaling in health and disease: defining the PAK4–CREB axis

Autor: So-Yoon Won, Jung-Jin Park, Eun-Young Shin, Eung-Gook Kim

Publikováno v: Experimental and Molecular Medicine, Vol 51, Iss 2, Pp 1-9 (2019)

Gene expression: The role of a regulatory enzyme in disease An enzyme that regulates an important controller of gene expression may offer a therapeutic target for cancer and other diseases. cAMP response element-binding protein (CREB) interacts with

Externí odkaz: https://doaj.org/article/71acb65c8b374f5989c068766fbc5147

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