Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Jung-Hwa Oh"'
Autor:
Jürgen Borlak, Yari Ciribilli, Alessandra Bisio, Saravanakumar Selvaraj, Alberto Inga, Jung-Hwa Oh, Reinhard Spanel
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-34 (2024)
Abstract Background Doxorubicin is an important anticancer drug, however, elicits dose-dependently cardiomyopathy. Given its mode of action, i.e. topoisomerase inhibition and DNA damage, we investigated genetic events associated with cardiomyopathy a
Externí odkaz:
https://doaj.org/article/e2adbab09e374e0287dee8c39f980553
Autor:
Hyoung-Yun Han, Bo-Kyung Kim, Jinhyung Rho, Se-Myo Park, Mi-Sun Choi, Soojin Kim, Min Beom Heo, Young-Su Yang, Jung-Hwa Oh, Tae Geol Lee, Seokjoo Yoon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Cerium oxide nanoparticles (CeO2 NPs, NM-212) are well-known for their catalytic properties and antioxidant potential, and have many applications in various industries, drug delivery, and cosmetic formulations. CeO2 NPs exhibit strong antimi
Externí odkaz:
https://doaj.org/article/1b66a2d4ca9b4c10b99a0a6a3ef55664
Autor:
Se-Myo Park, Mi-Sun Choi, Soojin Kim, Hyun Jegal, Hyoung-Yun Han, Hyang Sook Chun, Sang Kyum Kim, Jung-Hwa Oh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract In the field of drug discovery, natural products have emerged as therapeutic agents for diseases such as cancer. However, their potential toxicity poses significant obstacles in the developing effective drug candidates. To overcome this limi
Externí odkaz:
https://doaj.org/article/e5c04e9dad1b4cf9abacfb09baf4044c
Autor:
Mi-Sun Choi, Se-Myo Park, Soojin Kim, Hyun Jegal, Hyang-Ae Lee, Hyoung-Yun Han, Seokjoo Yoon, Sang-Kyum Kim, Jung-Hwa Oh
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 280, Iss , Pp 116516- (2024)
The assessment of neurotoxicity for environmental chemicals is of utmost importance in ensuring public health and environmental safety. Multielectrode array (MEA) technology has emerged as a powerful tool for assessing disturbances in the electrophys
Externí odkaz:
https://doaj.org/article/1109831dd2084c1d9ddee85aeb091bf0
Publikováno v:
BMC Genomic Data, Vol 24, Iss 1, Pp 1-3 (2023)
Abstract Objectives Thrombocytopenia is a condition that causes a low amount of blood platelets. Platelets are blood cells that play an essential role in blood coagulation. Therefore, thrombocytopenia can put the patient at risk for mild to severe bl
Externí odkaz:
https://doaj.org/article/667456ba3a47479e8bea8b44b94bc20c
Autor:
Mi-Ok Lee, Su-gi Lee, Cho-Rok Jung, Ye Seul Son, Jae-Woon Ryu, Kwang Bo Jung, Jun-Ho Ahn, Jung-Hwa Oh, Hyang-Ae Lee, Jung Hwa Lim, Janghwan Kim, Insu Jang, Jinhyuk Choi, Jaeeun Jung, Kunhyang Park, Byungwook Lee, Dae-Soo Kim, Mi-Young Son, Hyun-Soo Cho
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Quantitative methods to assess the quality of hPSC-derived organoids have not been developed. Here they present a prediction algorithm to assess the transcriptomic similarity between hPSC-derived organoids and the corresponding human target organs an
Externí odkaz:
https://doaj.org/article/27708e935ee5482783e2d1c6359a3d60
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1445 (2023)
Diclofenac effectively reduces pain and inflammation; however, its use is associated with hepato- and nephrotoxicity. To delineate mechanisms of injury, we investigated a clinically relevant (3 mg/kg) and high-dose (15 mg/kg) in minipigs for 4 weeks.
Externí odkaz:
https://doaj.org/article/132bc49c0a214b3eae84edd14f40a813
Publikováno v:
Journal of Biological Engineering, Vol 13, Iss 1, Pp 1-15 (2019)
Abstract Background Various hepatic models mimicking liver lobules have been investigated to evaluate the potential hepatotoxic effects of chemicals and drugs, but in vitro hepatic models of zonal hepatotoxicity have not yet been established. Herein,
Externí odkaz:
https://doaj.org/article/96ea80e7fe184d5b8a22ebdb7f1a2725
Autor:
Kwang Bo Jung, Hana Lee, Ye Seul Son, Mi-Ok Lee, Young-Dae Kim, Soo Jin Oh, Ohman Kwon, Sunwha Cho, Hyun-Soo Cho, Dae-Soo Kim, Jung-Hwa Oh, Matthias Zilbauer, Jeong-Ki Min, Cho-Rok Jung, Janghwan Kim, Mi-Young Son
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Human pluripotent stem cell-derived intestinal organoids (hIOs) are a useful model with which to study intestinal development and disease, but they require in vivo maturation to resemble adult tissue. Here, the authors show that T lymphocyte-derived
Externí odkaz:
https://doaj.org/article/a475745ef0d7496ba465e8488bf0de6b
Autor:
Sunyoung Woo, Soojin Kim, Hyunhong Kim, Young Woo Cheon, Seokjoo Yoon, Jung-Hwa Oh, Jongnam Park
Publikováno v:
Nanomaterials, Vol 11, Iss 11, p 3068 (2021)
The surface charge of iron oxide nanoparticles (IONPs) plays a critical role in the interactions between nanoparticles and biological components, which significantly affects their toxicity in vitro and in vivo. In this study, we synthesized three dif
Externí odkaz:
https://doaj.org/article/714d038f910042e79ee90b6e6e063b39