Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Jung Yaw Lin"'
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126725 (2015)
Inhibition of VEGFR2 activity has been proposed as an important strategy for the clinical treatment of hepatocellular carcinoma (HCC). In this study, we identified corosolic acid (CA), which exists in the root of Actinidia chinensis, as having a sign
Externí odkaz:
https://doaj.org/article/29c13cfa3ba942c8ac010cbe76206631
Publikováno v:
The American Journal of Chinese Medicine. 47:1459-1481
To evaluate the therapeutic effects of Chinese herbal medicine (CHM) for Alzheimer’s disease (AD), we evaluated five CHMs in oligomeric A[Formula: see text]-treated mouse primary hippocampal neuronal cultures. The aqueous extract from the root of P
Autor:
Te-Hsien Lin, Wan-Ling Chen, Chih-Ying Chao, Chih-Hsin Lin, Jung Yaw Lin, Chiung-Mei Chen, Guey Jen Lee-Chen, Mu-Chun Chiang, Hsuan-Yuan Lin, Mei-Ling Cheng, Yih-Ru Wu, Chia-Ning Chang, I-Cheng Chen
Publikováno v:
The American Journal of Chinese Medicine. 47:63-95
Nine autosomal dominant spinocerebellar ataxias (SCAs) are caused by an abnormal expansion of CAG trinucleotide repeats that encodes a polyglutamine (polyQ) tract within different genes. Accumulation of aggregated mutant proteins is a common feature
Autor:
Li-Ching Lee, Chiung-Mei Chen, Hao-Chun Wang, Hsiao-Han Hsieh, I-Sheng Chiu, Ming-Tsan Su, Hsiu-Mei Hsieh-Li, Chung-Hsin Wu, Guan-Chiun Lee, Guey-Jen Lee-Chen, Jung-Yaw Lin
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35302 (2012)
Spinocerebellar ataxia 17 (SCA17) is caused by expansion of the polyglutamine (polyQ) tract in human TATA-box binding protein (TBP) that is ubiquitously expressed in both central nervous system and peripheral tissues. The spectrum of SCA17 clinical p
Externí odkaz:
https://doaj.org/article/9c8b513e7652499da69408c1cae0f26b
Autor:
Bai Jiun Kuo, Yu Chih Lo, Chao Yu Yang, Wen Pin Kao, Su Chang Lin, Tsung Wei Su, Jung Yaw Lin, Shan Meng Lin
Publikováno v:
Structure. 25:407-420
Death domain (DD)-fold assemblies play a crucial role in regulating the signaling to cell survival or death. Here we report the crystal structure of the caspase recruitment domain (CARD)-CARD disk of the human apoptosome. The structure surprisingly r
Autor:
Hsiu Mei Hsieh-Li, Chintakunta Ramesh, Chi Mei Lee, Hei Jen Huang, Shu Ling Chen, Te Hsien Lin, Chih Hsin Lin, Hon Chung Fung, Guey Jen Lee-Chen, Chen Hsiang Huang, Chung Hsin Wu, Kuo-Hsuan Chang, Yi-Chun Chen, Ming Chung Lee, Ya Jen Chiu, Chin Chang Huang, Jung Yaw Lin, Ching Fa Yao
Publikováno v:
Neuropharmacology. 101:309-319
Alzheimer's disease (AD) is the most prevalent form of dementia associated with progressive cognitive decline and memory loss. Extracellular β-amyloid (Aβ) is a major constituent of senile plaques, one of the pathological hallmarks of AD. Aβ depos
Autor:
Guey Jen Lee-Chen, Mina Mesri, Hsuan Yuan Lin, Te Hsien Lin, Chiung Mei Chen, Shin Ying Lee, Jung Yaw Lin, Ya Jen Chiu, Kuo-Hsuan Chang, Chi Mei Lee
Publikováno v:
The American journal of Chinese medicine.
Amyloid [Formula: see text] (A[Formula: see text]) plays a major role in the pathogenesis of Alzheimer’s disease (AD). The accumulation of misfolded A[Formula: see text] causes oxidative and inflammatory damage leading to apoptotic cell death. Chin
Autor:
Yui Ping Weng, Der Yen Lee, Chao-Jung Chen, Ching Liang Hsieh, Yang Chang Wu, Jung-Yaw Lin, Yu Huei Liu, Hsin Ying Tsai
Publikováno v:
Phytomedicine : international journal of phytotherapy and phytopharmacology. 46
Background Pancreatic cancer (PC) remains the leading cause of cancer mortality, with limited therapeutic targets, and alterations in endoplasmic reticulum (ER)-related proteostasis may be a potential target for therapy. The root bark of Paeonia suff
Autor:
Yui-Ping Weng, Yu-Huei Liu, Sai-Wen Tang, Chi-Jung Liang, Jung-Yaw Lin, Chung-Yu Ku, Hsuan-Yuan Lin, Chao-Jung Chen
Publikováno v:
Scientific Reports
Hepatocellular carcinoma (HCC) remains the leading cause of cancer mortality with limited therapeutic targets. The endoplasmic reticulum (ER) plays a pivotal role in maintaining proteostasis in normal cells. However, alterations in proteostasis are o
Publikováno v:
Evidence-Based Complementary and Alternative Medicine, Vol 2017 (2017)
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-based Complementary and Alternative Medicine : eCAM
One of the pathogenic systems of Alzheimer’s disease (AD) is the formation ofβ-amyloid plaques in the brains of patients, and amyloidogenic activity becomes one of the therapeutic targets. Here, we report wogonin, one of the major active constitut