Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jung Sun Yi"'
Autor:
Nam Hee Youn, Eun Ji Kim, Jung-Sun Yi, Joo Hwan Kim, Ye-Jin Cho, Ki Taek Nam, Ki Sook Park, Jong Kwon Lee
Publikováno v:
Laboratory Animal Research, Vol 36, Iss 1, Pp 1-7 (2020)
Abstract Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test method to evaluate this has not been established. This study aime
Externí odkaz:
https://doaj.org/article/916deeed495a48acbee8e382c837afb4
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 1, Pp 94-104 (2007)
Pyruvate markedly reduces neuronal death following transient global ischemia. In the present study, we investigated the possible neuroprotective effect of pyruvate in focal ischemia. Pyruvate (62.5–250 mg/kg) treatment, regardless of whether given
Externí odkaz:
https://doaj.org/article/30266eb7a5db4cc5bf8e507205736a63
Autor:
Jong Kwon Lee, Ki Sook Park, Eun Ji Kim, Nam Hee Youn, Ki Taek Nam, Jung-Sun Yi, Yejin Cho, Joo Hwan Kim
Publikováno v:
Toxicol Res
In vivo phototoxicity testing is important for predicting drug-induced phototoxicity in humans. Currently, there is no internationally validated in vivo test method for the photosafety evaluation of pharmaceuticals. In this study, we evaluated the ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9ef7d90683a615dea0ab969f3651ad
https://europepmc.org/articles/PMC8476693/
https://europepmc.org/articles/PMC8476693/
Autor:
Ilyoung Ahn, Tae Sung Kim, Jong Kwon Lee, Hye Lyun Jeon, Kyung Yuk Ko, Joo Hwan Kim, Yoon-hee Hong, Jung-Sun Yi
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 827:59-67
Evaluation of DNA damage is critical during the development of new drugs because it is closely associated with genotoxicity and carcinogenicity. The in vivo comet assay to assess DNA damage is globally harmonized as OECD TG 489. However, a comet test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef601dbd1cbecfd988f38d73f1d86504
https://doi.org/10.1016/j.mrgentox.2018.01.010
https://doi.org/10.1016/j.mrgentox.2018.01.010
Autor:
Tae Sung Kim, Il Young Ahn, Hye Lyun Jeon, Minseong Lee, Soo Jung Sohn, Jin Seok Bang, Jong Kwon Lee, Youkyung Oh, Joo Hwan Kim, Kyungyuk Ko, Kinarm Ko, Hye Jeong Lee, Hye-Kyung Park, Jung-Sun Yi
Publikováno v:
Toxicological Research
Although alternative test methods based on the 3Rs (Replacement, Reduction, Refinement) are being developed to replace animal testing in reproductive and developmental toxicology, they are still in an early stage. Consequently, we aimed to develop al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d916f1a901a0d3edcc7cc71225d8b7f
https://doi.org/10.5487/tr.2017.33.2.107
https://doi.org/10.5487/tr.2017.33.2.107
Autor:
Tae Sung Kim, Kyung Min Lim, Ilyoung Ahn, Kyungyuk Ko, Joo Hwan Kim, Soojung Sohn, Mi Sook Jung, Souk Jin Seo, Yong Sun Lee, Jung Sun Yi, Im Kwon Seo
Publikováno v:
Regulatory Toxicology and Pharmacology. 83:13-22
The local lymph node assay using 5-bromo-2-deoxyuridine (BrdU) with flow cytometry (LLNA: BrdU-FCM) is a modified LLNA that is used to identify skin sensitizers by counting BrdU-incorporated lymph node cells (LNCs) with flow cytometry. Unlike other L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c83294c96e9b49f1a088b609d7c965
https://doi.org/10.1016/j.yrtph.2016.10.021
https://doi.org/10.1016/j.yrtph.2016.10.021
Autor:
Tae Sung Kim, Soojung Sohn, Miyoung Park, Ilyoung Ahn, Seung Jin Bae, Jung Eun Park, Mi Sook Jung, Yong Heo, Chang Yul Kim, Ai Young Lee, Eui-Bae Jeung, Tae Cheon Jeong, Yeong Chul Park, Kyeong Uk Yeo, Ji Hoon Jo, Eun Sun Jung, Eun Young Jeon, Jung Sun Yi, Won Hee Jang, Young-Jin Chun, Kyoung Mi Jung, Kyung Min Lim, Won Keun Seong
Publikováno v:
Regulatory Toxicology and Pharmacology. 80:183-194
Local lymph node assay: 5-bromo-2-deoxyuridine-flow cytometry method (LLNA: BrdU-FCM) is a modified non-radioisotopic technique with the additional advantages of accommodating multiple endpoints with the introduction of FCM, and refinement and reduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27dcf3ec630099f5679a04db43947708
https://doi.org/10.1016/j.yrtph.2016.06.009
https://doi.org/10.1016/j.yrtph.2016.06.009
Autor:
Ji Young Kim, Ah Rang Cho, Tae Sung Kim, Kyung Yuk Ko, Bae-Hwan Kim, Susun An, Kyo-Hyun Park, Jong Kwon Lee, Hak Kim, Mi Kyung Jeong, Won-hee Jang, Sun-A Cho, Joo Hwan Kim, Hye Lyun Jeon, Se-Ra Park, Yoon-hee Hong, Jung-Sun Yi, Ki Sook Park
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 63
In order to overcome the limitations of single in vitro eye irritation tests, Integrated Approaches to Testing Assessment strategies have been suggested for evaluating eye irritation. This study developed two tiered approaches combining alternative t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13736ee0cc033dccbe903f02c207f680
https://pubmed.ncbi.nlm.nih.gov/31648046
https://pubmed.ncbi.nlm.nih.gov/31648046
Autor:
Tae Sung Kim, Ki Taek Nam, Kyung Yuk Ko, Ga Young Lee, Mi Hye Hong, Il Young Ahn, Jung Sun Yi, Joo Hwan Kim, Jong Kwon Lee
Publikováno v:
Journal of pharmacological and toxicological methods. 92
Introduction A variety of in vitro tests to replace the Draize test have been developed; however, there is no available method for assessing the full spectrum of Globally Harmonized System (GHS) categories. Human cornea-like three-dimensional (3D) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69042d0f80eeb5f7a4f6a8166925cf22
https://pubmed.ncbi.nlm.nih.gov/29471020
https://pubmed.ncbi.nlm.nih.gov/29471020
Autor:
Tae Sung Kim, Kyungyuk Ko, Ilyoung Ahn, Seung Jin Bae, Jong Kwon Lee, Jung Sun Yi, Joo Hwan Kim, Souk Jin Seo, Byeol I. Han
Publikováno v:
Regulatory Toxicology and Pharmacology. 107:104401
The local lymph node assay using 5-bromo-2-deoxyuridine with flow cytometry (LLNA: BrdU-FCM) is a modified LLNA used to identify skin sensitizers. This assay measures the proliferation of auricular lymph node cells (LNCs) during the induction phase o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896febdef1cefbca51087697b109ebcd
https://doi.org/10.1016/j.yrtph.2019.05.026
https://doi.org/10.1016/j.yrtph.2019.05.026