Výsledky vyhledávání

Oligonucleotide-based Analysis of Differentially Expressed Genes in Hippocampus of Transgenic Mice Expressing NSE-controlled APPsw

Autor: Yang S. Kim, Su H. Lee, Dae Y. Hwang, Jung S. Cho, Sun B. Shim, Ji S. Sin, Seung Wan Jee, Chuel K. Kim, Soo Y. Choi, Jin H. Park, Yong K. Kim

Publikováno v: Neurochemical Research. 31:1035-1044

The complexity of Alzheimer's disease (AD) has made it difficult to examine its underlying mechanisms. A gene microarray offers a solution to the complexity through parallel analysis of most of the genes expressed in the hippocampal tissues from AD-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d3f8f81c42d6112323ee39fe8af621
https://doi.org/10.1007/s11064-006-9117-8

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NSE-Controlled Carboxyl-Terminus of APP Gene Over-Expressing in Transgenic Mice Induces Altered Expressions in Behavior, Aβ-42, and GSK3β Binding Proteins

Autor: Su H. Lee, Jae H. Oh, Jung S. Cho, Seung Wan Jee, Hwa J. Lim, Seok H. Lee, Yong K. Kim, Yhun Yhong Sheen, Sun B. Shim, Dae Y. Hwang

Publikováno v: Cellular and Molecular Neurobiology. 25:833-850

The amyloid protein precursor (APP) is cleaved in its intramembranous domain by gamma-secrease to generate amyloid beta and a free carboxyl-terminal intracellular fragment. The carboxyl-terminal of 105 amino acids of APP (APP-C105) plays a crucial ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a58e06953a19bc9703723144460594b
https://doi.org/10.1007/s10571-005-4937-7

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An In Vivo Bioassay for Detecting Antiandrogens Using Humanized Transgenic Mice Coexpressing the Tetracycline-Controlled Transactivator and Human CYP1B1 Gene

Autor: Yhun Yhong Sheen, Seung Wan Jee, Yong K. Kim, Dae Y. Hwang, Su J. Seo, Jung S. Cho, Su H. Lee, Jae H. Oh, Hyun Gu Kang, Sun B. Shim, Seok H. Lee

Publikováno v: International Journal of Toxicology. 24:157-164

The typical strategy used in analysis of antiandrogens involves the morphological changes of a marker in castrated rats Hershberger assay for the prostate, seminal vesicle, levator ani plus bulbocavernosus muscles (LABC), Cowper’s gland, and glans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23022dd416c77b95ef805ed109fa6d6c
https://doi.org/10.1080/10915810590948370

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MUTANT NICASTRIN PROTEIN CAN INDUCE THE CYTOCHROME C RELEASE AND THE BAX EXPRESSION

Autor: Dae Y. Hwang, Jung S. Cho, Yong K. Kim, Chul J. Lim

Publikováno v: International Journal of Neuroscience. 114:1277-1289

This study investigated whether nicastrin can induce apoptotic cell death in SK-N-MC cells. MTT assays revealed the transfected cells expressing mutant nicastrin, compared with those expressing wild nicastrin or the control vector, showing significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3e9c52b7c63dea280124064624e7f8
https://doi.org/10.1080/00207450490476048

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Differential expression of the tetracycline-controlled transactivator-driven human CYP1B1 gene in double-transgenic mice is due to androgens: application for detecting androgens and antiandrogens

Autor: Jin H. Hwang, Yhun Yhong Sheen, Sae H. Min, Su H. Lee, Dae Y. Hwang, Chae H. Lim, Hwa J. Lim, Jung S. Cho, Tae S. Kang, Kab Ryong Chae, Yong K. Kim, In S. Jang

Publikováno v: Archives of Biochemistry and Biophysics. 415:137-145

Differential expression of the tetracycline-controlled transactivator (tTA)-driven human cytochrome p450 (CYP) 1B1 gene was found in the livers of male mice, at high levels in neonates, but at low levels in adults. The goals of this study were to det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f7c6c33746573f6a2803677660ee7d
https://doi.org/10.1016/s0003-9861(03)00218-2

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Xenobiotic Response in Humanized Double Transgenic Mice Expressing Tetracycline-Controlled Transactivator and Human CYP1B1

Autor: Yun Y. Shin, Bum J. Kim, In S. Jang, Dae Youn Hwang, Kab Ryong Chae, Jin H. Hwang, Dong Hoon Shin, Yong K. Kim, Chae H. Lim, Jung S. Cho, Yeun J. Kim, Jun S. Goo

Publikováno v: Archives of Biochemistry and Biophysics. 395:32-40

The cytochrome P450 enzymes (P450s or CYPs) are a superfamily of hemeproteins that catalyze the monooxygenation of a wide range of endobiotic and xenobiotic substrates. A typical strategy in toxicological research and testing involves applying a toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34d732979a02dd46f774ac093a1a4cd
https://doi.org/10.1006/abbi.2001.2542

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Evaluation of Nasal Patency with 4‐Phase Rhinomanometry

Autor: Jung S. Cho, Sung M. Hong, Hyuk Soon Choi, Ju H. Kang, Heung Man Lee, Hye Rim Lee, Ji Young Um

Publikováno v: Otolaryngology–Head and Neck Surgery. 147

Objective: Objective assessment of nasal patency in patients with nasal septal deviation should be required to determine the severity of the symptoms. The purpose of this study was to compare results of nasal sound spectral analysis (NSSA) with resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72261e871a3037b92020ddb5ea090e70
https://doi.org/10.1177/0194599812451426a393

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Effect of Caffeic Acid on Nasal Polyp Derived Fibroblasts

Autor: Sung M. Hong, Ji Young Um, Seung Won Chung, Jung S. Cho, Heung Man Lee, Hye Rim Lee, Hyunkyung Park

Publikováno v: Otolaryngology–Head and Neck Surgery. 147

Objectives: Caffeic acids are known to have anti-oxidant, anti-inflammatory, immunomodulatory, and tissue reparative effects. The purposes of this study were to determine the effect of caffeic acid on transforming growth factor (TGF)-β1-induced myof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4f60ee65462c951dd9345b08c237621
https://doi.org/10.1177/0194599812451426a382

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The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

Autor: Joon Yong Cho, Chul H Kim, Dae Y. Hwang, Eun Bum Kang, In H. Cho, Hyun Seob Um, Jung S. Cho

Publikováno v: International Journal of Molecular Medicine. 25

Exercise training was suggested as a practical therapeutic strategy for human subjects suffering from Alzheimer's disease (AD) in our previous study. Therefore, the purpose of this study was to investigate the effects of combining exercise training w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d14a342615db6f2c917bb4ff18c62c
https://doi.org/10.3892/ijmm_00000350

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Differential effect of 7,12-dimethylbenz[a]anthracene on human and mouse CYP1B1 from livers of castrated transgenic mice

Autor: Su H. Lee, Chuel K. Kim, Yhun Yhong Sheen, Jung S. Cho, Kab Ryong Chae, Seung Wan Jee, Yong K. Kim, Mee K. Jang, Su J. Seo, Sun B. Shim, Min S. Kim, Soo Y. Choi, Dae Y. Hwang, Byoung Guk Kim, Ji S. Sin

Publikováno v: International journal of toxicology. 26(1)

Humanized transgenic mice coexpressing tetracycline-controlled transactivator ( tTA) and human cytochrome P450 1B1 (CYP1B1) ( hCYP1B1) have been created by this group. The aims of this study was to determine if 7,12-dimethylbenz[a]anthracene (DMBA) f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1434c73d65fd3df825d2340c8eda3fb1
https://pubmed.ncbi.nlm.nih.gov/17365149

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