Výsledky vyhledávání - "Jung Mao Hsu"

Akademický článek

Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

Autor: Riyao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Jun Yao, Hui Li, Meisi Yan, Wei-Chao Chang, Jung-Mao Hsu, Jong-Ho Cha, Jennifer L. Hsu, Cheng-Wei Chou, Xian Sun, Yalan Deng, Chao-Kai Chou, Dihua Yu, Mien-Chie Hung

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Galectin-9 regulates several cellular processes including TIM-3-mediated T cell death. Here the authors show that co-expressed PD-1 protects TIM-3+ T cells from galectin-9-induced cell death and that anti-galectin-9 in combination with GITR agonism p

Externí odkaz: https://doaj.org/article/d523a90c2f74464eb447b3b58eea546f

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Akademický článek

Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro

Publikováno v: EBioMedicine, Vol 74, Iss , Pp 103712- (2021)

Background: Despite clinical success with anti-spike vaccines, the effectiveness of neutralizing antibodies and vaccines has been compromised by rapidly spreading SARS-CoV-2 variants. Viruses can hijack the glycosylation machinery of host cells to sh

Externí odkaz: https://doaj.org/article/8fed32a6141e421c81852255ebc22345

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Akademický článek

CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

EZH2 phosphorylation by CDK2 promotes progression of triple-negative breast cancer (TNBC). Here, the authors show that this signaling axis downregulates ERα, and thus combinatorial blockade of CDK2 and EZH2 sensitizes TNBC cells to tamoxifen.

Externí odkaz: https://doaj.org/article/db070b7abc844972aa2cc8c48facb949

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Akademický článek

STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

Autor: Jung-Mao Hsu, Weiya Xia, Yi-Hsin Hsu, Li-Chuan Chan, Wen-Hsuan Yu, Jong-Ho Cha, Chun-Te Chen, Hsin-Wei Liao, Chu-Wei Kuo, Kay-Hooi Khoo, Jennifer L. Hsu, Chia-Wei Li, Seung-Oe Lim, Shih-Shin Chang, Yi-Chun Chen, Guo-xin Ren, Mien-Chie Hung

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

PD-L1 accumulates on cancer stem cells and favours immune evasion but the mechanism underlying this accumulation are unknown. Here the authors show that epithelial-mesenchymal transition induces glycosylation and stabilisation of PD-L1; antagonising

Externí odkaz: https://doaj.org/article/b6e5e0697fa048aeb6392035c75e7d85

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