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Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection.

Autor: Martin GM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Pholcharee T; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; Department of Biochemistry, University of Oxford, Oxford, OX1 3DR, UK., Oyen D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; Pfizer Inc, San Diego, CA, 92121, USA., Flores-Garcia Y; Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Gibson G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Moskovitz R; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Beutler N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Jung DD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Copps J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Gonzalez-Paez G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Emerling D; Atreca Inc, San Carlos, CA, 94070, USA., MacGill RS; PATH's Malaria Vaccine Initiative, Washington, DC, 20001, USA., Locke E; PATH's Malaria Vaccine Initiative, Washington, DC, 20001, USA., King CR; PATH's Malaria Vaccine Initiative, Washington, DC, 20001, USA., Zavala F; Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA. andrew@scripps.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jul 28; Vol. 14 (1), pp. 4546. Date of Electronic Publication: 2023 Jul 28.