Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Jung Bum, Shin"'
Publikováno v:
eLife, Vol 12 (2023)
The MRTF–SRF pathway has been extensively studied for its crucial role in driving the expression of a large number of genes involved in actin cytoskeleton of various cell types. However, the specific contribution of MRTF–SRF in hair cells remains
Externí odkaz:
https://doaj.org/article/71cbb9238dc447a79d1133f2d2d57e87
Autor:
Elizabeth L Wagner, Jun-Sub Im, Stefano Sala, Maura I Nakahata, Terence E Imbery, Sihan Li, Daniel Chen, Katherine Nimchuk, Yael Noy, David W Archer, Wenhao Xu, George Hashisaki, Karen B Avraham, Patrick W Oakes, Jung-Bum Shin
Publikováno v:
eLife, Vol 12 (2023)
Prolonged exposure to loud noise has been shown to affect inner ear sensory hair cells in a variety of deleterious manners, including damaging the stereocilia core. The damaged sites can be visualized as ‘gaps’ in phalloidin staining of F-actin,
Externí odkaz:
https://doaj.org/article/c58afd57aa30460798c8d8ef6686916d
Autor:
Courtney R. Rivet-Noor, Andrea R. Merchak, Sihan Li, Rebecca M. Beiter, Sangwoo Lee, Jalon Aaron Thomas, Anthony Fernández-Castañeda, Jung-Bum Shin, Alban Gaultier
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Current treatments for major depressive disorder are limited to neuropharmacological approaches and are ineffective for large numbers of patients. Recently, alternative means have been explored to understand the etiology of depression. Speci
Externí odkaz:
https://doaj.org/article/f8f17340c1414793a86253f65a3000ae
Autor:
Sihan Li, Andrew Mecca, Jeewoo Kim, Giusy A. Caprara, Elizabeth L. Wagner, Ting-Ting Du, Leonid Petrov, Wenhao Xu, Runjia Cui, Ivan T. Rebustini, Bechara Kachar, Anthony W. Peng, Jung-Bum Shin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
How the ear achieves its remarkable sensitivity is still not fully understood. In this study, the authors demonstrate that the deafness protein myosin-VIIa and its isoforms are essential for tensioning the tip link, thereby sensitizing the auditory r
Externí odkaz:
https://doaj.org/article/1e1c4ebb707d4e36929a5c7886e6304d
Autor:
Ting-Ting Du, James B. Dewey, Elizabeth L. Wagner, Runjia Cui, Jinho Heo, Jeong-Jin Park, Shimon P. Francis, Edward Perez-Reyes, Stacey J. Guillot, Nicholas E. Sherman, Wenhao Xu, John S Oghalai, Bechara Kachar, Jung-Bum Shin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
In contrast to the extensively studied mechanosensory hair bundle, the cuticular plate is not as well understood. In this study, authors describe the discovery of a hair cell protein called LIM only protein 7, which is localized in the cuticular plat
Externí odkaz:
https://doaj.org/article/c2ec714b45bc41bf96953f0212beec8a
Autor:
Eric R. Wengert, Ian C. Wenker, Elizabeth L. Wagner, Pravin K. Wagley, Ronald P. Gaykema, Jung-Bum Shin, Manoj K. Patel
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death amongst patients whose seizures are not adequately controlled by current therapies. Patients with SCN8A encephalopathy have an elevated risk for SUDEP. While transgenic mouse m
Externí odkaz:
https://doaj.org/article/c4a1dcfd7e464abf8d51bcd2c1132236
Autor:
Courtney Rivet-Noor, Andrea R Merchak, Caroline Render, Rebecca M. Beiter, Ryan Brown, Erica Slogar, Austin Keeler, G. Brett Moreau, Sihan Li, Deniz E. Olgun, Tobey Mihn Huu Phan, Jung-Bum Shin, Chris Deppmann, Alban Gaultier
Depression is a common mental health condition with a large social and economic impact. While depression etiology is multifactorial, chronic stress is a well-accepted contributor to disease onset. In addition, depression is associated with altered gu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c67d79d019f30214094cc579b32262c
https://doi.org/10.1101/2022.10.13.512135
https://doi.org/10.1101/2022.10.13.512135
Autor:
Wagner, Elizabeth L., Jun-Sub Im, Sala, Stefano, Nakahata, Maura I., Imbery, Terence E., Sihan Li, Chen, Daniel, Nimchuk, Katherine, Noy, Yael, Archer, David W., Wenhao Xu, Hashisaki, George, Avraham, Karen B., Oakes, Patrick W., Jung-Bum Shin
Publikováno v:
eLife; 6/9/2023, p1-31, 31p
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Cisplatin has been regarded as an effective and versatile chemotherapeutic agent for nearly 40 years. Though the associated dose-dependent ototoxicity is known, the cellular mechanisms by which cochleovestibular hair cell death occur are not well und
Externí odkaz:
https://doaj.org/article/e50d731cc7334070b9860c687c053f45
Autor:
Courtney R. Rivet-Noor, Andrea R. Merchak, Sihan Li, Rebecca M. Beiter, Sangwoo Lee, Jalon Aaron Thomas, Anthony Fernández-Castañeda, Jung-Bum Shin, Alban Gaultier
Current treatments for major depressive disorder are limited to neuropharmacological approaches and are ineffective for large numbers of patients. Recently, alternative means have been explored to understand the etiology of depression. Specifically,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63e07ac9ce454ba41e05347e9a32e15
https://doi.org/10.21203/rs.3.rs-1181536/v1
https://doi.org/10.21203/rs.3.rs-1181536/v1