Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jung Beom Son"'
Autor:
Debra Dorotea, Songling Jiang, Eun Seon Pak, Jung Beom Son, Hwan Geun Choi, Sung-Min Ahn, Hunjoo Ha
Publikováno v:
Experimental & Molecular Medicine. 54:1086-1097
Src family kinases (SFKs) have been implicated in the pathogenesis of kidney fibrosis. However, the specific mechanism by which SFKs contribute to the progression of diabetic kidney disease (DKD) remains unclear. Our preliminary transcriptome analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed6e65ee41cc542f51eb7ba282bb6ba
https://doi.org/10.1038/s12276-022-00810-3
https://doi.org/10.1038/s12276-022-00810-3
Autor:
Hong-ryul Jung, Sunghwan Kim, Jihye Yoo, Chan mi Park, Somi Lee, Hyoju Lee, Youngyi Lee, Jinhee Park, Kyungah Seo, Dong-Hyuk Seo, Eunhwa Ko, Jung Beom Son, Deakwon Kim, Hwan Geun Choi, Nam Doo Kim
Publikováno v:
Cancer Research. 82:P2-13
Breast cancer (BC) is the second most common cancer associated with brain metastasis (BM) and among patients with breast cancer brain metastasis (BCBM), human epidermal growth factor receptor 2 (HER2)-positive breast cancer is most likely to develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3170c068e75cf611b8cd2ba82f43cac3
https://doi.org/10.1158/1538-7445.sabcs21-p2-13-15
https://doi.org/10.1158/1538-7445.sabcs21-p2-13-15
Autor:
Yuancheng Mao, Chang Yeob Han, Lihua Hao, Younho Lee, Jung Beom Son, Hwangeun Choi, Mi Rin Lee, Jae Do Yang, Suk Kyun Hong, Kyung‐Suk Suh, Hee Chul Yu, Nam Doo Kim, Eun Ju Bae, Byung‐Hyun Park
Publikováno v:
Hepatology (Baltimore, Md.)REFERENCES. 76(2)
p21-activated kinase 4 (PAK4), an oncogenic protein, has emerged as a promising target for anticancer drug development. Its role in oxidative stress conditions, however, remains elusive. We investigated the effects of PAK4 signaling on hepatic ischem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81a4dede041582a15b186885855bf8e
https://pubmed.ncbi.nlm.nih.gov/35108418
https://pubmed.ncbi.nlm.nih.gov/35108418
Autor:
Kwangwoo Hwang, SeoHyun Jo, Jieun Choi, Ga-young Choi, Jiseon Choi, Ji-Hye Kwon, Dong-Guk Shin, Jiyeon Kim, Se-Hyuk Kim, Haelee Kim, Ha Yeon Cho, Jung Beom Son, Nam Doo Kim, Hwan Geun Choi, Daekwon Kim, Sunghwan Kim
Publikováno v:
Cancer Research. 82:LB521-LB521
FDA approved three RAF inhibitors for the treatment of tumors containing BRAFV600 mutations, but one of the major drawbacks of these type I RAF inhibitors is to activate MAPK signaling pathway, instead of inhibiting signaling, which is referred to as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eed613962e35bc81098d392570afd873
https://doi.org/10.1158/1538-7445.am2022-lb521
https://doi.org/10.1158/1538-7445.am2022-lb521
Autor:
Younho, Lee, Hyunkyung, Kim, Haelee, Kim, Ha Yeon, Cho, Jun-Goo, Jee, Kyung-Ah, Seo, Jung Beom, Son, Eunhwa, Ko, Hwan Geun, Choi, Nam Doo, Kim, Ikyon, Kim
Publikováno v:
Journal of medicinal chemistry. 64(10)
Triple-negative breast cancer (TNBC) is an aggressive breast-cancer subtype associated with poor prognosis and high relapse rates. Monopolar spindle 1 kinase (MPS1) is an apical dual-specificity protein kinase that is over-expressed in TNBC. We herei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5318148535a7bed12adc0dfbcf524041
https://pubmed.ncbi.nlm.nih.gov/33942608
https://pubmed.ncbi.nlm.nih.gov/33942608
Autor:
Melissa R. Junttila, Jason E. Long, Robert Warne, Sunghwan Kim, Younho Lee, Hwan Kim, Juhee Kang, Jiyoon Seok, Jihye Yoo, Youngyi Lee, Dong-Hyuk Seo Seo, Jung Beom Son, Daekwon Kim, Hwan Geun Choi, Nam Doo Kim, Tatiana Zavorotinskaya, Chelsea Chan, Matthew Panuwat, Jessica Sun, Jae H. Chang, Lori S. Friedman
Publikováno v:
Molecular Cancer Therapeutics. 20:P234-P234
Amplification of human epidermal growth factor receptor 2 (HER2) is an oncogenic driver found in approximately 25% of breast cancer. Despite the arsenal of HER2-directed therapies available to patients, more than 50% of patients with HER2 amplificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d03df66b667546d6cf07c2b636b629
https://doi.org/10.1158/1535-7163.targ-21-p234
https://doi.org/10.1158/1535-7163.targ-21-p234
Publikováno v:
Tetrahedron Letters. 51:4942-4946
Naturally occurring L-783277 which belongs to 14-membered resorcylic acid lactones (RALs) turned out to be a potent kinase inhibitor against MEK (MAP kinase kinase). We successfully accomplished efficient and enantioselective total synthesis of L-783
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6940c535e99f651b0b475edf84332b8
https://doi.org/10.1016/j.tetlet.2010.07.122
https://doi.org/10.1016/j.tetlet.2010.07.122
Publikováno v:
Bulletin of the Korean Chemical Society. 31:653-663
Enantioselective total synthesis of (-)-clavosolide A and B was reported in full including the synthesis of proposed structure of (-)-clavosoldie A (1), revised structure of (-)-clavosoldie A (5), and revised structure of (-)-clavosoldie B (6). The r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98020cbf3e8a8c04dddc5ebff772ac75
https://doi.org/10.5012/bkcs.2010.31.03.653
https://doi.org/10.5012/bkcs.2010.31.03.653
Publikováno v:
Tetrahedron Letters. 46:7721-7723
Cyclopropyl derivative of 2,6-di-tert-butylphenol is synthesized as a probe to investigate the mechanism of base-catalyzed autooxidation of phenol derivatives. Our study indicates that one electron reduction of molecular oxygen from phenolate gives p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb6c22f958b1cfa61dc405c3d6684a0e
https://doi.org/10.1016/j.tetlet.2005.09.029
https://doi.org/10.1016/j.tetlet.2005.09.029
Publikováno v:
ChemInform. 41
Enantioselective total synthesis of (-)-clavosolide A and B was reported in full including the synthesis of proposed structure of (-)-clavosoldie A (1), revised structure of (-)-clavosoldie A (5), and revised structure of (-)-clavosoldie B (6). The r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::197f6d43cbb186d661d37170b3bc1c92
https://doi.org/10.1002/chin.201031208
https://doi.org/10.1002/chin.201031208