Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Jung‐Nyoung Heo"'
The antitumor activity of a novel GCN2 inhibitor in head and neck squamous cell carcinoma cell lines
Autor:
Jeongjae Lee, Bhumsuk Keam, Soyeon Kim, Jung-Nyoung Heo, Eunkyo Joung, Miso Kim, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo
Publikováno v:
Translational Oncology, Vol 27, Iss , Pp 101592- (2023)
Background: General control nonderepressible 2 (GCN2) senses amino acid deprivation and activates activating transcription factor 4 (ATF4), which regulates many adaptive genes. We evaluated the impact of AST-0513, a novel GCN2 inhibitor, on the GCN2-
Externí odkaz:
https://doaj.org/article/cc6188dda1c8451bad50a54922dbe9cf
Autor:
Hyun‐Yi Kim, Sehee Choi, Ji‐Hye Yoon, Hwan Jung Lim, Hyuk Lee, Jiwon Choi, Eun Ji Ro, Jung‐Nyoung Heo, Weontae Lee, Kyoung Tai No, Kang‐Yell Choi
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 4, Pp 375-387 (2016)
Abstract Bone anabolic agents promoting bone formation and rebuilding damaged bones would ideally overcome the limitations of anti‐resorptive therapy, the current standard prescription for osteoporosis. However, the currently prescribed parathyroid
Externí odkaz:
https://doaj.org/article/2f40ad989b144c7692d267ba676ee2a5
Publikováno v:
ARKIVOC, Vol 2002, Iss 6, Pp 49-58 (2002)
Externí odkaz:
https://doaj.org/article/61f6e2a553114b8cb52955315f708d52
Synthesis and biological evaluation of benzoxepinoindol‐1‐one analogs as Brd4 bromodomain inhibitors
Publikováno v:
Bulletin of the Korean Chemical Society. 44:213-221
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5552fab63e3fff15617e119ba6cd353
https://doi.org/10.1002/bkcs.12656
https://doi.org/10.1002/bkcs.12656
The antitumor activity of a novel GCN2 inhibitor in head and neck squamous cell carcinoma cell lines
Autor:
Jeongjae Lee, Bhumsuk Keam, Soyeon Kim, Jung-Nyoung Heo, Eunkyo Joung, Miso Kim, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo
Publikováno v:
Translational oncology. 27
General control nonderepressible 2 (GCN2) senses amino acid deprivation and activates activating transcription factor 4 (ATF4), which regulates many adaptive genes. We evaluated the impact of AST-0513, a novel GCN2 inhibitor, on the GCN2-ATF4 pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8091a633a07d7a615657bdfa2c7122dd
https://pubmed.ncbi.nlm.nih.gov/36436443
https://pubmed.ncbi.nlm.nih.gov/36436443
Autor:
Dasol Lee, Byumseok Koh, Jung-Nyoung Heo, Sung-Bum Park, Sunjoo Ahn, Hee Min Yoo, Eunyoung Yoon
Publikováno v:
Journal of Pharmaceutical Sciences. 108:3704-3712
Integrin αvβ3 is widely expressed in various types of human cancer lines and plays a key role in angiogenesis for tumor growth and metastasis. Delivery of therapeutics to αvβ3-expressing tumors can thus be a promising approach for treating cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::584496787cb4143cac2f221880d288c3
https://doi.org/10.1016/j.xphs.2019.07.011
https://doi.org/10.1016/j.xphs.2019.07.011
Autor:
Chong Ock Lee, Sung Woong Moon, Heung Kyoung Lee, Chul Woong Chung, Sang Un Choi, Minjin Yoo, Young Hun Kim, Minsung Kim, Miyoun Yoo, Hye Kyung Chang, Chi Hoon Park, Ji-Eun Kim, Suhkneung Pyo, Kwan-Young Jung, Jung-Nyoung Heo, Chang-Soo Yun
Publikováno v:
Biochemical and Biophysical Research Communications. 503:882-887
Bromodomain-containing protein 4 (Brd4) is known to play a key role in tumorigenesis. It binds acetylated histones to regulate the expression of numerous genes. Because of the importance of brd4 in tumorigenesis, much research has been undertaken to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36e94d2e06ef81c94be197122569424
https://doi.org/10.1016/j.bbrc.2018.06.091
https://doi.org/10.1016/j.bbrc.2018.06.091
Autor:
Woosun Kwon, Kyoung Tai No, Jung Nyoung Heo, Xuemei Jin, Tae Soo Kim, Hyun Cheol Chung, Jiwon Choi
Publikováno v:
Bulletin of the Korean Chemical Society. 39:294-299
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a83aa87da239ef716340b3e242860668
https://doi.org/10.1002/bkcs.11382
https://doi.org/10.1002/bkcs.11382
Autor:
Ansook Yang, Jung-Nyoung Heo, Daeyong Kim, Ae-Kyeong Kim, Min Ju Jo, Min-Hyo Ki, Joo-Youn Lee, Eunyoung Yoon, Sang-Bae Han, Youngwook Ham, Kyu-Sun Lee, Sungchan Cho, Miri Choi
Publikováno v:
Phytomedicine. 92:153695
Background Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a significant pathogenic factor in Down syndrome (DS), wherein DYRK1A is overexpressed by 1.5-fold because of trisomy of human chromosome 21. Thus, DYRK1A inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56798e755c5226ee27ffd1419016bd2
https://doi.org/10.1016/j.phymed.2021.153695
https://doi.org/10.1016/j.phymed.2021.153695
Autor:
Hoon Jai Chun, Man So Han, Seung Taek Hong, Bong Rae Cho, Kyu Cheol Paik, Seong Jun Park, Sung An Kwon, Tae Hyeong Kim, Ji Woo Choi, Jung Nyoung Heo, Eun Sun Kim
Publikováno v:
Analytical Chemistry. 89:9830-9835
We have developed two-photon (TP) pH-sensitive probes (BH-2 and BHEt-1) that exhibit absorption and emission maxima at 370 and 466 nm, and TP absorption cross-section values of 51 and 61 GM (1 GM = 10–50cm4s/photon), respectively, at 750 nm and pH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c377ad0981f9b4ca5d08636c1c05fe9
https://doi.org/10.1021/acs.analchem.7b01804
https://doi.org/10.1021/acs.analchem.7b01804