Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Junfeng Xia"'
Publikováno v:
PeerJ, Vol 12, p e17991 (2024)
Most computational methods for predicting driver mutations have been trained using positive samples, while negative samples are typically derived from statistical methods or putative samples. The representativeness of these negative samples in captur
Externí odkaz:
https://doaj.org/article/9ad4e40b1f6f40c9b1dd2fee86f1de0e
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
Osteoarthritis (OA) is a worldwide joint disease, leading to the physical pain, stiffness, and even disability. Lactate dehydrogenase A (LDHA) is known as a lactylation mediator that can regulate histone lactylation of its target genes. However, the
Externí odkaz:
https://doaj.org/article/d2cbd1710e834b98873a396db5072883
Publikováno v:
ACS Omega, Vol 8, Iss 44, Pp 41930-41942 (2023)
Externí odkaz:
https://doaj.org/article/58367753aec64a86ac8cc1c3b4b09e21
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107958- (2023)
Summary: Alternative splicing (AS) regulation has an essential role in complex diseases. However, the AS profiles in the hippocampal (HIPPO) region of human brain are underexplored. Here, we investigated cis-acting sQTLs of HIPPO region in 264 sample
Externí odkaz:
https://doaj.org/article/2eac700e6dd041ecaa1fd59dc8c5969e
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Driver mutations play a critical role in the occurrence and development of human cancers. Most studies have focused on missense mutations that function as drivers in cancer. However, accumulating experimental evidence indicates that syn
Externí odkaz:
https://doaj.org/article/eff0b747cf364a22a33ce9ffb8fa51f1
Publikováno v:
BMC Bioinformatics, Vol 22, Iss S3, Pp 1-16 (2021)
Abstract Background As one of the deadliest diseases in the world, cancer is driven by a few somatic mutations that disrupt the normal growth of cells, and leads to abnormal proliferation and tumor development. The vast majority of somatic mutations
Externí odkaz:
https://doaj.org/article/3c8bbb5747a4471bb5081cefd51baa78
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1010511 (2022)
Prediction of therapeutic peptide is a significant step for the discovery of promising therapeutic drugs. Most of the existing studies have focused on the mono-functional therapeutic peptide prediction. However, the number of multi-functional therape
Externí odkaz:
https://doaj.org/article/8acd601d76b5464088376fb514908d2b
Publikováno v:
BMC Bioinformatics, Vol 22, Iss S3, Pp 1-12 (2021)
Abstract Background DNA-binding hot spots are dominant and fundamental residues that contribute most of the binding free energy yet accounting for a small portion of protein–DNA interfaces. As experimental methods for identifying hot spots are time
Externí odkaz:
https://doaj.org/article/f4859ab812bb42e08f870caa3011217b
Publikováno v:
Buildings, Vol 13, Iss 6, p 1416 (2023)
Prestressed rebars are usually used to apply vertical prestress to concrete to prevent web cracking. The reduction of working stress will affect the durability of the structure. However, the existing working stress detection methods for prestressed r
Externí odkaz:
https://doaj.org/article/a0f11084e64349ec8b2f914676fb67c0
Publikováno v:
BMC Bioinformatics, Vol 21, Iss S13, Pp 1-10 (2020)
Abstract Background Identification of hot spots in protein-DNA interfaces provides crucial information for the research on protein-DNA interaction and drug design. As experimental methods for determining hot spots are time-consuming, labor-intensive
Externí odkaz:
https://doaj.org/article/159de50f043e4140a5014eaee5a0606a