Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Junfen Xu"'
Autor:
Ying Luo, Mengda Niu, Yanfei Liu, Miaochang Zhang, Yuanyuan Deng, Dan Mu, Junfen Xu, Shiyuan Hong
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Cervical cancer (CC) stands as a significant health threat to women globally, with high-risk human papillomaviruses as major etiologic agents. The DNA damage repair (DDR) protein topoisomerase I (TOP1) has been linked to various cancers,
Externí odkaz:
https://doaj.org/article/ce2fb40691f543fa91158c70ec526adc
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-14 (2022)
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors are efficacious in treating platinum-sensitive ovarian cancer (OC), but demonstrate limited efficiency in patients with platinum-resistant OC. Thus, further investigations into combined strategi
Externí odkaz:
https://doaj.org/article/7d21a15fc0d747189920e26c5a19a03b
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract High-grade serous ovarian, fallopian tube or peritoneal carcinoma is an aggressive subtype of ovarian cancer that frequently develops resistance to chemotherapy. It remains contested whether the resistance is caused by the acquisition of nov
Externí odkaz:
https://doaj.org/article/f3c765c40b9d49eda4d41a14ad474814
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract RNA-binding proteins (RBPs) have been related to cancer development. Their functions in cervical cancer, however, are virtually unknown. One of these proteins, Mex-3 RNA-binding family member D (MEX3D), has been recently found to exhibit onc
Externí odkaz:
https://doaj.org/article/ef7b1ad530694947a9cf003c756623af
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-10 (2022)
Abstract High grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer and HGSOC patients often appear with metastasis, leading to the poor prognosis. Up to date, the extrachromosomal circular DNAs (eccDNAs) have been show
Externí odkaz:
https://doaj.org/article/3f5e8f8391214bd5b721e30643369ee2
Autor:
Yangyang Li, Yixuan Cen, Mengyan Tu, Zhenzhen Xiang, Sangsang Tang, Weiguo Lu, Hongbo Zhang, Junfen Xu
Publikováno v:
Research, Vol 6 (2023)
Platinum-based chemotherapy remains the main systemic treatment of ovarian cancer (OC). However, the inevitable development of platinum and poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi) resistance is associated with poor outcomes,
Externí odkaz:
https://doaj.org/article/86b8a0d90dec484ea32eff84cb9c957c
Autor:
Yixuan Cen, Tingjia Zhu, Yanan Zhang, Lu Zhao, Jiawei Zhu, Lingfang Wang, Junfen Xu, Tian Ding, Xing Xie, Xinyu Wang, Weiguo Lu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 227-240 (2022)
Metastasis is the main cause of cervical cancer lethality, but to date, no effective treatment has been developed to block metastasis. Circular RNAs (circRNAs) were recently found to be involved in cancer metastasis. In this study, we identified a do
Externí odkaz:
https://doaj.org/article/90a2f4ef778f4d5b9f280d6784327b33
Autor:
Junfen Xu, Yuanming Shen, Conghui Wang, Sangsang Tang, Shiyuan Hong, Weiguo Lu, Xing Xie, Xiaodong Cheng
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract The poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors show survival benefits in ovarian cancer patients with BRCA1/2 mutation or homologous recombination (HR) deficiency, but only limited efficacy in HR-proficient ones. Another
Externí odkaz:
https://doaj.org/article/170f485243834593b335a1d6d286f515
Autor:
Junfen Xu, Yanan Zhang, Yongjie Huang, Xiaohui Dong, Zhenzhen Xiang, Jian Zou, Luyao Wu, Weiguo Lu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 1176-1190 (2020)
Circular RNAs (circRNAs) function as efficient microRNA (miRNA) sponges that regulate gene expression in the pathogenesis of many human malignancies. However, their roles in cervical adenocarcinoma remain largely unknown. In this study, we aimed to s
Externí odkaz:
https://doaj.org/article/b487891687774878891c07073fe41e16
Autor:
Yanan Zhang, Lu Zhao, Shizhou Yang, Yixuan Cen, Tingjia Zhu, Lingfang Wang, Lili Xia, Yuwan Liu, Jian Zou, Junfen Xu, Yang Li, Xiaodong Cheng, Weiguo Lu, Xinyu Wang, Xing Xie
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-18 (2020)
Abstract Background Circular RNAs (circRNAs) have been reported to play key roles in the development of various cancers. However, the biological functions and clinical significance of most circRNAs are still elusive. The purpose of this study was to
Externí odkaz:
https://doaj.org/article/b04e877c8e844f1e81dfc32b2330f0e8