Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Junfa Fan"'
Autor:
Tonika Bohnert, Brian T. Hopkins, Stig Hansen, Laura Silvian, Patrick Cullen, Min Zhong, Stacey A. Heumann, Junfa Fan, Noah Bell, Elisabeth Mertsching, Tracy J. Jenkins, Ella Negrou, Eris Bame, Douglas Marcotte, Kevin L. Otipoby, Michael J. Romanowski, Bob McDowell, Wenjin Yang, Daniel A. Erlanson, Patrick Conlon, Mark T. Cancilla, Minna Bui, Urjana Poreci, Daniel Scott, Tarra Fuchs-Knotts, Jon K. Bowden-Verhoek
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2905-2913
Since the approval of ibrutinib for the treatment of B-cell malignancies in 2012, numerous clinical trials have been reported using covalent inhibitors to target Bruton's tyrosine kinase (BTK) for oncology indications. However, a formidable challenge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f47fdcd71f2c89e2f54cba793dfbcb
https://doi.org/10.1016/j.bmc.2019.05.021
https://doi.org/10.1016/j.bmc.2019.05.021
Autor:
Ella Negrou, Tracy J. Jenkins, Mark T. Cancilla, Douglas Marcotte, Minna Bui, Wenjin Yang, Brian T. Hopkins, Mukush Lulla, Daniel A. Erlanson, Eris Bame, Patrick Conlon, Stig Hansen, Elisabeth Mertsching, Tonika Bohnert, Noah Bell, Daniel Scott, Marx Isaac, Stacey A. Heumann, Junfa Fan, Ying Liu, Tarra Fuchs-Knotts, Laura Silvian, Chuck Gua, YuTing Liu, Jon K. Bowden-Verhoek, Michael J. Romanowski, Bob McDowell, Patrick Cullen, Min Zhong
Publikováno v:
Bioorganic & Medicinal Chemistry. 44:116275
Bruton's tyrosine kinase (BTK) is an essential node on the BCR signaling in B cells, which are clinically validated to play a critical role in B-cell lymphomas and various auto-immune diseases such as Multiple Sclerosis (MS), Pemphigus, and rheumatoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08827c5ed0774a88dae1ef91956919b8
https://doi.org/10.1016/j.bmc.2021.116275
https://doi.org/10.1016/j.bmc.2021.116275
Publikováno v:
Buildings, Vol 14, Iss 9, p 2705 (2024)
The shear stirrups and bend-up reinforcement in ultra-high-performance concrete (UHPC) beams could potentially be excluded due to the superior mechanical properties of UHPC. This paper reports the new findings of an experimental research into the fac
Externí odkaz:
https://doaj.org/article/ac29d85395454eb4878acc3bd79a9655
Publikováno v:
Buildings, Vol 14, Iss 5, p 1374 (2024)
Due to the extraordinary mechanical properties of ultra-high-performance concrete (UHPC), the shear stirrups in UHPC beams could potentially be eliminated. This study aimed to determine the effect of beam height and steel fiber volume content on the
Externí odkaz:
https://doaj.org/article/b94da1597442414ba7f9fbd5745cae81
Publikováno v:
Tetrahedron Letters. 51:828-831
An efficient method is developed for the synthesis of imidazo[1,5-a]pyridine from the reaction of 1,1-dibromo-1-alkenes with 2-aminomethylpyridines. The reaction requires an inorganic base, such as Na2CO3, and moderate heating in DMF to proceed. Mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e932bee6afe73be079f901eb652eb08d
https://doi.org/10.1016/j.tetlet.2009.12.013
https://doi.org/10.1016/j.tetlet.2009.12.013
Publikováno v:
Journal of Fluorine Chemistry. 129:112-118
Horner-Emmons fluoroolefination of an aryl aldehyde followed by introduction of a second fluorine via "FBr" addition provides an original approach to the preparation of 1-alkyl-2-aryl-1,2-difluoroethenes. The utility of this procedure is demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b3826d365cd005d63895e22094c285
https://doi.org/10.1016/j.jfluchem.2007.09.006
https://doi.org/10.1016/j.jfluchem.2007.09.006
Publikováno v:
Journal of Medical Microbiology. 55:407-415
A bromotyrosine alkaloid family of antimicrobial agents was synthesized using the known structure of a natural inhibitor of the mycobacterial mycothiolS-conjugate amidase (MCA) as a template. This series of compounds represents a novel class of anti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07c4f299f33506567ad93bc9c976ab7
https://doi.org/10.1099/jmm.0.46319-0
https://doi.org/10.1099/jmm.0.46319-0
Publikováno v:
The Journal of Organic Chemistry. 68:2798-2802
Tryptamines disubstituted at the β-position with fluorine have been synthesized as part of our research program to study the effects of fluorine substitution on the biological activities of neuroactive amines. Treatment of N-Boc-3-azidoacetyl indole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3741b87b47d4058359336e04799a877
https://doi.org/10.1021/jo020731c
https://doi.org/10.1021/jo020731c
Publikováno v:
Journal of Fluorine Chemistry. 115:137-142
Horner–Wadsworth–Emmons olefination of ring-fluorinated N -trityl-imidazole carboxaldehydes with dialkyphosphonoacetic acid esters produced ring-fluorinated imidazolyl- E - and Z -acrylate esters. Stereochemistry was controlled by choice of phosh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01618c0bb5727faea9a27b3cfb1dfbc9
https://doi.org/10.1016/s0022-1139(02)00045-3
https://doi.org/10.1016/s0022-1139(02)00045-3
Publikováno v:
Journal of Fluorine Chemistry. 115:27-32
6-Fluoro- meta -tyrosine ( 1 ) was prepared from 2-fluoro-5-hydroxybenzaldehyde ( 6 ) based on an Erlenmeyer–Plochl azlactone strategy. Products of expected metabolism of the amino acid, including 6-fluoro- meta -tyramine ( 2 ) and its O -sulfate c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e96ef2fb376441eec08d10a2172ed4a4
https://doi.org/10.1016/s0022-1139(02)00013-1
https://doi.org/10.1016/s0022-1139(02)00013-1