Zobrazeno 1 - 10
of 22
pro vyhledávání: '"June-Chul Lee"'
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Type 1 autoimmune diabetes is an autoimmune disease characterized by specific destruction of pancreatic β-cells producing insulin. Recent studies have shown that gut microbiota and immunity are closely linked to systemic immunity, affecting the bala
Externí odkaz:
https://doaj.org/article/878875f150af406d8296e16b65413387
Autor:
June-Chul Lee, Hae-Youn Lee, Tae Kang Kim, Min-Soo Kim, Young Mi Park, Jinyoung Kim, Kihyoun Park, Mi-Na Kweon, Seok-Hyung Kim, Jin-Woo Bae, Kyu Yeon Hur, Myung-Shik Lee
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187515 (2017)
Consumption of a typical Western diet is a risk factor for several disorders. Metabolic syndrome is the most common disease associated with intake of excess fat. However, the incidence of inflammatory bowel disease is also greater in subjects consumi
Externí odkaz:
https://doaj.org/article/342f6f5612b94c4bb3acf72c010c2016
Autor:
Seok-Hyung Kim, Jin-Woo Bae, Min-Soo Kim, Jinyoung Kim, June Chul Lee, Myung-Shik Lee, Kyu Yeon Hur, Hae Youn Lee, Wenying Quan
Publikováno v:
Autophagy. 12:1390-1403
Autophagy, which is critical for the proper turnover of organelles such as endoplasmic reticulum and mitochondria, affects diverse aspects of metabolism, and its dysregulation has been incriminated in various metabolic disorders. However, the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc68f4eada95e5d547535c0c2d081ca
https://doi.org/10.1080/15548627.2016.1184799
https://doi.org/10.1080/15548627.2016.1184799
Autor:
Jin-Woo Bae, Na-Ri Shin, Tae Woong Whon, June Chul Lee, Myung-Shik Lee, Min-Soo Kim, Hae Youn Lee
Publikováno v:
Gut
Background Recent evidence indicates that the composition of the gut microbiota contributes to the development of metabolic disorders by affecting the physiology and metabolism of the host. Metformin is one of the most widely prescribed type 2 diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7923fc5a85796baa783b6af0663597d2
https://doi.org/10.1136/gutjnl-2012-303839
https://doi.org/10.1136/gutjnl-2012-303839
Autor:
Seok-Hyung Kim, Jin-Woo Bae, Mi-Na Kweon, Young Mi Park, Jinyoung Kim, June-Chul Lee, Hae-Youn Lee, Min-Soo Kim, Tae Kang Kim, Kyu Yeon Hur, Kihyoun Park, Myung-Shik Lee
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187515 (2017)
PLoS ONE
PLoS ONE
Consumption of a typical Western diet is a risk factor for several disorders. Metabolic syndrome is the most common disease associated with intake of excess fat. However, the incidence of inflammatory bowel disease is also greater in subjects consumi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5685fc275db047b0cf52ec66a1962fa
https://doi.org/10.1371/journal.pone.0187515
https://doi.org/10.1371/journal.pone.0187515
Autor:
Joanne Ng, Vinay Kumar, Seog Bae Oh, June Chul Lee, In Jung Jang, Kyung Mi Lee, Cassian Yee, Seon Ah Lim, Tae Jin Kim, Yong Ho Kim, Kwanghee Kim, Jung Eun Lee
Publikováno v:
European journal of immunology. 44(6)
Along with MHC class I (MHCI), 2B4 provides nonredundant NK-cell inhibition in mice. The immunoregulatory role of 2B4 has been increasingly appreciated in models of tumor and viral infection, however, the interactions among 2B4, MHCI, and other activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21cd472bf4f17439c0bd084133ef0e7
https://pubmed.ncbi.nlm.nih.gov/24610736
https://pubmed.ncbi.nlm.nih.gov/24610736
Publikováno v:
Diabetes/metabolism research and reviews. 27(8)
Recently, a couple of articles suggested the possibility that apoptosis of pancreatic β-cells induces inflammatory/immune responses to β-cells. Such a theory is based on the assumption that apoptotic cells can, under certain circumstances, induce i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431290b7678055128f87d7d6e75ad3c2
https://pubmed.ncbi.nlm.nih.gov/22069262
https://pubmed.ncbi.nlm.nih.gov/22069262
Autor:
Seung Hoon Oh, Sunshin Kim, Moon-Kyu Lee, June-Chul Lee, Dohoon Kim, Myung-Shik Lee, Kwang-Won Kim
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 187(10)
We have reported that apoptotic β cells undergoing secondary necrosis, called “late apoptotic (LA) β cells,” stimulated APCs and induced diabetogenic T cell priming through TLR2, which might be one of the initial events in autoimmune diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a8613a6f8a7760e51f485f05f1fa5f
https://pubmed.ncbi.nlm.nih.gov/21998452
https://pubmed.ncbi.nlm.nih.gov/21998452
Publikováno v:
Tumori. 97(3)
Aims and background Elevated TGF-β1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. However, the molecular mechanism of immunosuppression by TGF-β1 is not yet clarified. Methods IL-2-activated human NK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3d7a4997280f063b2156c06ab142ac
https://pubmed.ncbi.nlm.nih.gov/21789015
https://pubmed.ncbi.nlm.nih.gov/21789015
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 182(10)
The presence of membrane-bound TGF-β1 (mTGF-β1) has been recently observed in regulatory T cells, but only a few studies have reported the same phenomenon in cancer cells. In this study, we investigate the regulation of mTGF-β1 expression in five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e504087944cb622b04641c6982bdd4
https://pubmed.ncbi.nlm.nih.gov/19414763
https://pubmed.ncbi.nlm.nih.gov/19414763