Zobrazeno 1 - 10
of 12
pro vyhledávání: '"June Sonnenberg-Reines"'
Autor:
Karen L. Marquis, Suzan Aschmies, Hua Zhou, Robert Martone, Kevin Atchison, June Sonnenberg-Reines, Anthony Kreft, Menelas N. Pangalos, Thomas A. Comery, J. Steven Jacobsen, George Diamantidis, Xiaohai Gong
Publikováno v:
The Journal of Neuroscience. 25:8898-8902
Transgenic mice (Tg2576) overexpressing the Swedish mutation of the human amyloid precursor protein display biochemical, pathological, and behavioral markers consistent with many aspects of Alzheimer's disease, including impaired hippocampal function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b492d9ca4d6361b6a9a861cd42e865
https://doi.org/10.1523/jneurosci.2693-05.2005
https://doi.org/10.1523/jneurosci.2693-05.2005
Publikováno v:
AGE. 21:15-23
We have developed a simple in vitro assay using tissue homogenates that allows detection and characterization of several endogenous proteolytic activities which convert Alzheimer’s amyloid precursor protein (APP) to the smaller, carboxy-terminal fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf18d489071935d1142a43e235076f1
https://doi.org/10.1007/s11357-998-0003-y
https://doi.org/10.1007/s11357-998-0003-y
Autor:
Jonathan A. Bard, Xioahai Gong, Karissa Adkins, Michael W. Leach, Michael E. Burczynski, Mei Jin, Margaret M. Zaleska, Glen Frick, Hua Zhou, Kevin Atchison, Magid Abou-Gharbia, Anthony Kreft, Shaiu-Ching Sun, Erik Wagner, Carrie Balliet, J. Steven Jacobsen, Peter H. Reinhart, Boyd L. Harrison, Jane Z. Xu, Sangeeta Raje, Robert Martone, David Riddell, Menelas N. Pangalos, June Sonnenberg-Reines, S. Bradley Forlow, Peimin Lu, Aram Oganesian, Hong I. Wan, Thomas A. Comery, David W. Clarke, Xinyi Huang, Scott C. Mayer, Cathleen Gonzales, Suzan Aschmies, Ronald L. Magolda, Donna M. Huryn
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 331(2)
The presenilin containing gamma-secretase complex is responsible for the regulated intramembraneous proteolysis of the amyloid precursor protein (APP), the Notch receptor, and a multitude of other substrates. gamma-Secretase catalyzes the final step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01864b0edb6ae8cb4168e2f7f50f033a
https://pubmed.ncbi.nlm.nih.gov/19671883
https://pubmed.ncbi.nlm.nih.gov/19671883
Autor:
Joshua D Berkowitz, Boyd L. Harrison, Robert Martone, Hua Zhou, Micheal Chlenov, Yun Hu, Peimin Lu, Koi Michele Morris, June Sonnenberg-Reines, S. Aschmies, Joan E. Sabalski, Kerri Lipinski, George Diamantidis, Kevin Atchison, Thomas J. Caggiano, Shaiu-Ching Sun, Zheng Xu, Jun Pu, Anthony F. Kreft, Dave R. Riddell, Yiqun Wang, Lynn Resnick, Mei Jin, Donna M. Huryn, Erik Wagner, J. Steven Jacobsen
Publikováno v:
Bioorganicmedicinal chemistry. 17(13)
gamma-Secretase inhibitors have been shown to reduce the production of beta-amyloid, a component of the plaques that are found in brains of patients with Alzheimer's disease. A novel series of heterocyclic sulfonamide gamma-secretase inhibitors that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb35335c5e137415c463df8839ade10
https://pubmed.ncbi.nlm.nih.gov/19443228
https://pubmed.ncbi.nlm.nih.gov/19443228
Autor:
Ron Magolda, Joseph R. Stock, David Riddell, Scott C. Mayer, John Ellingboe, Ting Wang, Melissa Lin, Hua Zhou, Yun Hu, Galante Rocco, Dennis M. Kubrak, Mei Jin, Madelene Miyoko Antane, Aram Oganesian, Anthony Kreft, Margaret M. Zaleska, Derek C. Cole, Michael Chlenov, Minsheng Zhang, Menelas N. Pangalos, Alex M. Porte, J. Steven Jacobsen, Lynn Resnick, Joseph Zeldis, Kristi Fan, Donna M. Huryn, Uday Jain, Shaiu-Ching Sun, Cathleen Gonzales, Boyd L. Harrison, William E. Moore, Peimin Lu, Magid Abou-Gharbia, Thomas A. Comery, Molly Hoke, Suzan Aschmies, George Diamantidis, Kevin R. Woller, Peter H. Reinhart, Robert Martone, June Sonnenberg-Reines, Kevin Atchison, Erik Wagner, Zheng Xu, Douglas M. Ho, Kenneth Alfred Martin Kremer
Publikováno v:
Journal of medicinal chemistry. 51(23)
SAR on HTS hits 1 and 2 led to the potent, Notch-1-sparing GSI 9, which lowered brain Abeta in Tg2576 mice at 100 mg/kg po. Converting the metabolically labile methyl groups in 9 to trifluoromethyl groups afforded the more stable analogue 10, which h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c063931baa66ff9027ac9d0def280432
https://pubmed.ncbi.nlm.nih.gov/19012391
https://pubmed.ncbi.nlm.nih.gov/19012391
Autor:
Peimin Lu, David S. Casebier, Dennis Kubrak, S. Aschmies, David Riddell, William Jay Moore, Zheng Wang, Mei Jin, Hua Zhou, Thomas A. Comery, John W. Ellingboe, Shaiu-Ching Sun, Erik Wagner, Aram Oganesian, Joseph Raymond Stock, Boyd L. Harrison, Zheng Xu, Robert Martone, George Diamantidis, Madelene Antane, Kevin Atchison, Kevin R. Woller, Yun Hu, June Sonnenberg-Reines, Charles William Mann, J. Steven Jacobsen, Anthony F. Kreft, Derek C. Cole
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(3)
Accumulation of beta-amyloid (Abeta), produced by the proteolytic cleavage of amyloid precursor protein (APP) by beta- and gamma-secretase, is widely believed to be associated with Alzheimer's disease (AD). Research around the high-throughput screeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f145553716fc797084c8e75ab564dd0
https://pubmed.ncbi.nlm.nih.gov/19097890
https://pubmed.ncbi.nlm.nih.gov/19097890
Autor:
Steven Jacobsen, Thomas Comery, Suzan Aschmies, Hua Zhou, Mei Jin, Kevin Atchison, Jane Xu, Erik Wagner, June Sonnenberg-Reines, Anthony Kreft, Roy Sun, Peimin Liu, Xiaohai Gong, Margaret Zaleska, Karissa Adkins, Aram Oganesian, Maximillian Folletti, Hong Wan, Scott Mayer, Molly Hoke, Peter Reinhart, Boyd Harrison, Ron Magolda, Menelas Pangalos, Robert Martone
Publikováno v:
Alzheimer's & Dementia. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bec3fd30b590df9418fb44aedf87f0d4
https://doi.org/10.1016/j.jalz.2008.05.1379
https://doi.org/10.1016/j.jalz.2008.05.1379
Autor:
Hua Zhou, John W. Ellingboe, Derek Cecil Cole, Donna M. Huryn, Suzan Aschmies, Mei Jin, Charles William Mann, William E. Moore, Robert Martone, David S. Casebier, George Diamantidis, Zheng Xu, Alex Porte, Kevin R. Woller, Kevin Atchison, Anthony F. Kreft, Erik Wagner, Yun Hu, June Sonnenberg-Reines, Joseph T. Lundquist, J. Steven Jacobsen, Dennis Kubrak, Dave R. Riddell, Peimin Lu, Diane B. Hauze, Joseph Raymond Stock, Shaiu-Ching Sun, Boyd L. Harrison, Aram Oganesian
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(14)
Using a cell-based assay, we have identified a new series of Notch-sparing gamma-secretase inhibitors from HTS screening leads 2a and 2e. Lead optimization studies led to the discovery of analog 8e with improved gamma-secretase inhibitory potency and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2478e69d5a0c4998fbffb6b302c18ddb
https://pubmed.ncbi.nlm.nih.gov/18556202
https://pubmed.ncbi.nlm.nih.gov/18556202
Autor:
Hua Zhou, Diane B. Hauze, John W. Ellingboe, Robert Martone, Shaiu-Ching Sun, Dennis Kubrak, Alex Porte, David Riddell, Joseph Raymond Stock, Kevin Atchison, Susan Aschmies, Will Moore, Anthony F. Kreft, Boyd L. Harrison, Yun Hu, Kevin R. Woller, Charles William Mann, June Sonnenberg-Reines, Peimin Lu, Derek Cecil Cole, Steven Jacobsen, Donna M. Huryn, Mei Jin, Zheng Xu, Erik Wagner
Publikováno v:
Alzheimer's & Dementia. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8591d843baaef6a709c2f577d6dc4b07
https://doi.org/10.1016/j.jalz.2006.05.1984
https://doi.org/10.1016/j.jalz.2006.05.1984
Autor:
Eric Gould Gundersen, Shaiu-Ching Sun, Scott Christian Mayer, Kristi Fan, Robert Martone, Donna M. Huryn, June Sonnenberg-Reines, J. Steven Jacobsen, Kimberly Haas, Anthony F. Kreft, Hua Zhou
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(7)
Alzheimer's disease (AD) is a debilitating disease widely thought to be associated with the accumulation of beta amyloid (Abeta) in the brain. Inhibition of gamma-secretase, one of the enzymes responsible for Abeta production, may be a useful strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d56483e4a8342be0c78b8c2c7a59bb
https://pubmed.ncbi.nlm.nih.gov/15780628
https://pubmed.ncbi.nlm.nih.gov/15780628