Zobrazeno 1 - 10
of 16
pro vyhledávání: '"June R. Merwin"'
Publikováno v:
Delivery Strategies for Antisense Oligonucleotide Therapeutics ISBN: 9781315150901
Delivery Strategies for Antisense Oligonucleotide Therapeutics
Delivery Strategies for Antisense Oligonucleotide Therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83b0112c9796fb18a596ab3f42b76994
https://doi.org/10.1201/9781315150901-17
https://doi.org/10.1201/9781315150901-17
Publikováno v:
International Journal of Pharmaceutics. 182:21-32
Numerous studies have shown that chitosan, a mucoadhesive polymer, is a potential enhancer for transmucosal drug delivery. To further understand the mechanisms involved in chitosan action on the mucosal barrier, the activity of chitosan on the functi
Autor:
Ellen P. Carmichael, George L. Spitalny, Robert Plourde, Michael F. Ernst, Mark A. Findeis, Brett S. Robinson, June R. Merwin, Joanne L. Suchoski
Publikováno v:
Drug Delivery. 2:136-143
Receptor-mediated targeting to the liver using galactose-terminated ligands is a promising strategy for site-specific delivery of antiviral drugs for treatment of hepatitis B virus infection. Optimization of drug conjugates for receptor-mediated deli
Autor:
Wendy L. Thomas, G. Stephen Noell, Mark A. Findeis, June R. Merwin, Henry C. Chiou, George L. Spitalny, Timothy D. McKee, Mary E. DeRome
Publikováno v:
Bioconjugate Chemistry. 5:612-620
In vivo gene therapy shows promise as a treatment for both genetic and acquired disorders. The hepatic asialoglycoprotein receptor (ASGPr) binds asialoorosomucoid-polylysine-DNA (ASOR-PL-DNA) complexes and allows targeted delivery to hepatocytes. The
Publikováno v:
Biochemical and Biophysical Research Communications. 189:315-323
Human endothelial cells were transiently transfected with E-Selectin which enabled us to study tumor cell/endothelial interactions following engagement of E-Selectin without the added complications of metabolic stimulation, morphological changes, and
Publikováno v:
Biochemical and Biophysical Research Communications. 175:589-595
Functional biological assays were performed using a hybrid molecule of Transforming Growth Factor-Beta (TGF-5 beta) where nine amino acids near the cleavage site of TGF-beta 1 were substituted with nine amino acids located in the identical position o
Autor:
Olivier Kocher, Leonard Bell, Adeline Tucker, Joseph A. Madri, Craig T. Basson, June R. Merwin
Publikováno v:
Annals of the New York Academy of Sciences. 593:243-258
CD5-mediated specific delivery of DNA to T lymphocytes: compartmentalization augmented by adenovirus
Autor:
G. Stephen Noell, Wendy L. Thomas, Ellen P. Carmichael, Henry C. Chiou, Mary E. DeRome, June R. Merwin, Norma Robert, George L. Spitalny
Publikováno v:
Journal of immunological methods. 186(2)
Specific DNA delivery has been achieved via interactions between an asialoorosomucoid-polylysine conjugate and the asialoglycoprotein receptor. We have now extended this technology to another cell type. In order to achieve DNA delivery uniquely to T
Publikováno v:
Gene Therapeutics ISBN: 9781468468243
Human gene therapy has advanced during the past ten years from a theoretical concept to a rapidly emerging technology. Tremendous technological strides in recombinant DNA methodologies have fostered molecular studies in such fields as regulation of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f79bad05a37aa9679a3aa8b562ca085a
https://doi.org/10.1007/978-1-4684-6822-9_8
https://doi.org/10.1007/978-1-4684-6822-9_8
Publikováno v:
Trends in biotechnology. 11(5)
The general concept of targeted delivery of therapeutic agents was first recognized by Paul Ehrlich at the turn of the century I. Only recently has this strategy been applied to the delivery of DNA-protein complexes to cells 2. Most of the research o