Zobrazeno 1 - 10
of 112
pro vyhledávání: '"June L. Round"'
Autor:
D. Garrett Brown, Michaela Murphy, Roberto Cadeddu, Rickesha Bell, Allison Weis, Tyson Chiaro, Kendra Klag, Jubel Morgan, Hilary Coon, W. Zac Stephens, Marco Bortolato, June L. Round
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Multiple neurological disorders are associated with gastrointestinal (GI) symptoms, including autism spectrum disorder (ASD). However, it is unclear whether GI distress itself can modify aspects of behavior. Here, we show that mice that expe
Externí odkaz:
https://doaj.org/article/fb44e8b1995b409a99434735f789b45b
Autor:
Kendra A. Klag, Rickesha Bell, Xuan Jia, Alexandra Seguin, J. Alan Maschek, Mary Bronner, James E. Cox, June L. Round, Diane M. Ward
Publikováno v:
Nutrients, Vol 16, Iss 12, p 1804 (2024)
Iron deficiency is the number one nutritional problem worldwide. Iron uptake is regulated at the intestine and is highly influenced by the gut microbiome. Blood from the intestines drains directly into the liver, informing iron status and gut microbi
Externí odkaz:
https://doaj.org/article/76afd29c33324cec9502196e7b6feb74
Autor:
Caroline Himbert, Jennifer Ose, Biljana Gigic, Richard Viskochil, Kelly Santuci, Tengda Lin, Anjelica Ashworth, Jessica N. Cohan, Courtney L. Scaife, Jolanta Jedrzkiewicz, Victoria Damerell, Katelyn M. Atkins, Jun Gong, Matthew G. Mutch, Corey Bernadt, Seth Felder, Julian Sanchez, Stacey A. Cohen, Mukta K. Krane, Nathan Hinkle, Elizabeth Wood, Anita R. Peoples, Jane C. Figueiredo, Adetunji T. Toriola, Erin M. Siegel, Christopher I. Li, David Shibata, Kenneth Boucher, June L. Round, Alexis B. Ulrich, Martin Schneider, Lyen C. Huang, Sheetal Hardikar, Cornelia M. Ulrich
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Physical activity and BMI have been individually associated with cancer survivorship but have not yet been studied in combinations in colorectal cancer patients. Here, we investigate individual and combined associations of physica
Externí odkaz:
https://doaj.org/article/f367c0f04c41460f813d8acfd96ef8d1
Autor:
Kaylyn M. Bauer, Morgan C. Nelson, William W. Tang, Tyson R. Chiaro, D. Garrett Brown, Arevik Ghazaryan, Soh-Hyun Lee, Allison M. Weis, Jennifer H. Hill, Kendra A. Klag, Van B. Tran, Jacob W. Thompson, Andrew G. Ramstead, Josh K. Monts, James E. Marvin, Margaret Alexander, Warren P. Voth, W. Zac Stephens, Diane M. Ward, Aaron C. Petrey, June L. Round, Ryan M. O’Connell
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Intercellular communication is critical for homeostasis in mammalian systems, including the gastrointestinal (GI) tract. Exosomes are nanoscale lipid extracellular vesicles that mediate communication between many cell types. Notably, the roles of imm
Externí odkaz:
https://doaj.org/article/28e27534285f41e8b7743abd9a89a3a7
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Eosinophilic esophagitis (EoE) is an increasingly common food allergy disease of the esophagus that received its medical designation code in 2008. Despite this recency, great strides have been made in the understanding of EoE pathophysiology and type
Externí odkaz:
https://doaj.org/article/377b60acc0804c1c9ef7ba8a809a3f9f
Autor:
Thomas B. Huffaker, H. Atakan Ekiz, Cindy Barba, Soh-Hyun Lee, Marah C. Runtsch, Morgan C. Nelson, Kaylyn M. Bauer, William W. Tang, Timothy L. Mosbruger, James E. Cox, June L. Round, Warren P. Voth, Ryan M. O’Connell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
IFNy can polarize macrophages in the tumour microenvironment to an inflammatory state and thereby contributes to their anti-tumour function. Here the authors show an underlying mechanism in this process is IFNy-driven STAT1 occupancy and activation o
Externí odkaz:
https://doaj.org/article/b194e57208eb4a39a01b6f84ed5db4cc
Autor:
John Michael S. Sanchez, Daniel J. Doty, Ana Beatriz DePaula-Silva, D. Garrett Brown, Rickesha Bell, Kendra A. Klag, Amanda Truong, Jane E. Libbey, June L. Round, Robert S. Fujinami
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Abstract Background Multiple sclerosis (MS) is an inflammatory demyelinating disease that affects 2.5 million people worldwide. Growing evidence suggests that perturbation of the gut microbiota, the dense collection of microorganisms that colonize th
Externí odkaz:
https://doaj.org/article/8532539cee2a41329b1d2acb156ebb93
Autor:
W. Zac Stephens, Jason L. Kubinak, Arevik Ghazaryan, Kaylyn M. Bauer, Rickesha Bell, Kate Buhrke, Tyson R. Chiaro, Allison M. Weis, William W. Tang, Josh K. Monts, Ray Soto, H. Atakan Ekiz, Ryan M. O’Connell, June L. Round
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109916- (2021)
Summary: Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC cl
Externí odkaz:
https://doaj.org/article/c1e5d4d89cc84888a5fa9fbe24b048c9
Autor:
Andrew G. Ramstead, Jared A. Wallace, Soh-Hyun Lee, Kaylyn M. Bauer, William W. Tang, H. Atakan Ekiz, Thomas E. Lane, Ahmad A. Cluntun, Matthew L. Bettini, June L. Round, Jared Rutter, Ryan M. O’Connell
Publikováno v:
Cell Reports, Vol 30, Iss 9, Pp 2889-2899.e6 (2020)
Summary: Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvat
Externí odkaz:
https://doaj.org/article/85eca401df46476092567316c9937106
Autor:
Thomas B. Huffaker, Ruozhen Hu, Marah C. Runtsch, Erin Bake, Xinjian Chen, Jimmy Zhao, June L. Round, David Baltimore, Ryan M. O'Connell
Publikováno v:
Cell Reports, Vol 2, Iss 6, Pp 1697-1709 (2012)
An increased understanding of antitumor immunity is necessary for improving cell-based immunotherapies against human cancers. Here, we investigated the roles of two immune system-expressed microRNAs (miRNAs), miR-155 and miR-146a, in the regulation o
Externí odkaz:
https://doaj.org/article/3066eb1fb52b4a3d9edb71d00409d57f