Zobrazeno 1 - 10
of 62
pro vyhledávání: '"June L. Biedler"'
Autor:
Jeanette D. Walton, David R. Kattan, Sharon K. Thomas, Barbara A. Spengler, Hong-Fen Guo, June L. Biedler, Nai-Kong V. Cheung, Robert A. Ross
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 6, Pp 838-845 (2004)
Cellular heterogeneity is a hallmark of human neuroblastoma tumors and cell lines. Within a single neuroblastoma are cells from distinct neural crest lineages whose relative abundance is significant for prognosis. We postulate that a self-renewing mu
Externí odkaz:
https://doaj.org/article/3d82b77190214067a8f8a24165bf19e2
Autor:
Kristin D. Kisselbach, Sotiris N Nikolopoulos, Audrey E. Evans, Robert A. Ross, June L. Biedler, Barbara A. Spengler
Publikováno v:
Oncogene. 19:380-386
alpha-Actinins are actin-binding proteins important in organization of the cytoskeleton and in cell adhesion. We have cloned and characterized a cDNA from human neuroblastoma cell variants which encodes the second non-muscle alpha-actinin isoform des
Autor:
Francis M. Sirotnak, Ching H. Yang, Berend Tolner, Judy H. Chiao, June L. Biedler, Barbara A. Spengler, Krishnendu Roy
Publikováno v:
Cancer Genetics and Cytogenetics. 105:29-38
A variant of the L1210 cell (L1210/R83) selected in the presence of the lipophilic antifolate, metoprine, and a concentration of the natural diastereoisomer of 5-formyltetrahydrofolate, lL5CHO-folateH4, suboptimum for growth exhibited a 35-fold incre
Publikováno v:
Blood. 84:3465-3472
During development, mice with mutations of stem cell factor (SCF) or its receptor c-kit exhibit defects in melanogenesis, as well as hematopoiesis and gonadogenesis. Because melanocytes derive from neural crest cells, the role of SCF and c-kit was in
Autor:
June L. Biedler, Barbara A. Spengler
Publikováno v:
Cancer and Metastasis Reviews. 13:191-207
Spontaneously transformed Chinese hamster lung cells with high levels of resistance (approximately 100-fold to 70,000-fold) to actinomycin D, daunorubicin, or vincristine exhibit morphology and growth patterns characteristic of normal cells in vitro
Autor:
June L. Biedler
Publikováno v:
Cancer. 70:1799-1809
Mammalian cells exposed to a single cytotoxic natural product drug, such as vincristine or dactinomycin, can develop resistance to the selective agent and cross-resistance to a broad spectrum of structurally and functionally distinct antibiotics and
Autor:
Gennaro Melino, Margherita Annicchiarico-Petruzzelli, June L. Biedler, Lucia Piredda, Mauro Piacentini, Serafina Oliverio
Publikováno v:
International Journal of Cancer. 52:271-278
Neuroblastomas in culture are characterized by the presence of 2 morphologically and biochemically distinct phenotypes (i.e., neural "N-type" and flat substrate-adherent "S-type") which undergo transdifferentiation. Human neuroblastoma SK-N-BE(2) cel
Autor:
June L. Biedler, Michael P. LaQuaglia, Marian B. Meyers, Elizabeth B. Kopp, Barbara A. Spengler
Publikováno v:
Journal of Pediatric Surgery. 26:1107-1112
Neuroblastoma remains a significant problem in pediatric oncology. Recently a "multidrug-resistance" gene that may cause cells to become resistant to various chemotherapeutic agents has been cloned. The gene encodes the high-molecular-weight plasma m
Publikováno v:
Cancer letters. 197(1-2)
Human neuroblastoma arises from the developing neural crest. Tumors are categorized clinically by their location, age at diagnosis, spread/metastasis, and degree of cellular maturation and heterogeneity. Our long-term studies have shown the presence