Zobrazeno 1 - 10
of 112
pro vyhledávání: '"June L Round"'
Autor:
D Garrett Brown, Raymond Soto, Soumya Yandamuri, Colleen Stone, Laura Dickey, Joao Carlos Gomes-Neto, Elissa D Pastuzyn, Rickesha Bell, Charisse Petersen, Kaitlin Buhrke, Robert S Fujinami, Ryan M O'Connell, W Zac Stephens, Jason D Shepherd, Thomas E Lane, June L Round
Publikováno v:
eLife, Vol 8 (2019)
Symbiotic microbes impact the function and development of the central nervous system (CNS); however, little is known about the contribution of the microbiota during viral-induced neurologic damage. We identify that commensals aid in host defense foll
Externí odkaz:
https://doaj.org/article/8f9c877ea32349559ba7e12f43882bd9
Autor:
Marah C Runtsch, Morgan C Nelson, Soh-Hyun Lee, Warren Voth, Margaret Alexander, Ruozhen Hu, Jared Wallace, Charisse Petersen, Vanja Panic, Claudio J Villanueva, Kimberley J Evason, Kaylyn M Bauer, Timothy Mosbruger, Sihem Boudina, Mary Bronner, June L Round, Micah J Drummond, Ryan M O'Connell
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007970 (2019)
Identifying regulatory mechanisms that influence inflammation in metabolic tissues is critical for developing novel metabolic disease treatments. Here, we investigated the role of microRNA-146a (miR-146a) during diet-induced obesity in mice. miR-146a
Externí odkaz:
https://doaj.org/article/0b801b0c45b84c1488fd88a3d64a9028
Autor:
Jared Wallace, Ruozhen Hu, Timothy L Mosbruger, Timothy J Dahlem, W Zac Stephens, Dinesh S Rao, June L Round, Ryan M O'Connell
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153689 (2016)
Mammalian microRNA expression is dysregulated in human cancer. However, the functional relevance of many microRNAs in the context of tumor biology remains unclear. Using CRISPR-Cas9 technology, we performed a global loss-of-function screen to simulta
Externí odkaz:
https://doaj.org/article/a12ce76b539a4da6a0900b63f0d0c5e2
Autor:
D. Garrett Brown, Michaela Murphy, Roberto Cadeddu, Rickesha Bell, Allison Weis, Tyson Chiaro, Kendra Klag, Jubel Morgan, Hilary Coon, W. Zac Stephens, Marco Bortolato, June L. Round
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Multiple neurological disorders are associated with gastrointestinal (GI) symptoms, including autism spectrum disorder (ASD). However, it is unclear whether GI distress itself can modify aspects of behavior. Here, we show that mice that expe
Externí odkaz:
https://doaj.org/article/fb44e8b1995b409a99434735f789b45b
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
The mammalian intestinal tract is a unique site in which a large portion of our immune system and the 10^14 commensal organisms that make up the microbiota reside in intimate contact with each other. Despite the potential for inflammatory immune resp
Externí odkaz:
https://doaj.org/article/ee8a259b05f241b4b8cea8cfac7ee724
Autor:
Jason L Kubinak, June L Round
Publikováno v:
PLoS Pathogens, Vol 8, Iss 7, p e1002785 (2012)
Externí odkaz:
https://doaj.org/article/0a5e16fdbe774952afbcb7ec4b505c2e
Autor:
Lisa A Humphries, Meredith H Shaffer, Faruk Sacirbegovic, Tamar Tomassian, Kerrie-Ann McMahon, Patrick O Humbert, Oscar Silva, June L Round, Kogo Takamiya, Richard L Huganir, Janis K Burkhardt, Sarah M Russell, M Carrie Miceli
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45276 (2012)
The polarized reorganization of the T cell membrane and intracellular signaling molecules in response to T cell receptor (TCR) engagement has been implicated in the modulation of T cell development and effector responses. In siRNA-based studies Dlg1,
Externí odkaz:
https://doaj.org/article/5159c08438b74cfcb4ab902da3231388
Autor:
Kendra A. Klag, Rickesha Bell, Xuan Jia, Alexandra Seguin, J. Alan Maschek, Mary Bronner, James E. Cox, June L. Round, Diane M. Ward
Publikováno v:
Nutrients, Vol 16, Iss 12, p 1804 (2024)
Iron deficiency is the number one nutritional problem worldwide. Iron uptake is regulated at the intestine and is highly influenced by the gut microbiome. Blood from the intestines drains directly into the liver, informing iron status and gut microbi
Externí odkaz:
https://doaj.org/article/76afd29c33324cec9502196e7b6feb74
Autor:
Caroline Himbert, Jennifer Ose, Biljana Gigic, Richard Viskochil, Kelly Santuci, Tengda Lin, Anjelica Ashworth, Jessica N. Cohan, Courtney L. Scaife, Jolanta Jedrzkiewicz, Victoria Damerell, Katelyn M. Atkins, Jun Gong, Matthew G. Mutch, Corey Bernadt, Seth Felder, Julian Sanchez, Stacey A. Cohen, Mukta K. Krane, Nathan Hinkle, Elizabeth Wood, Anita R. Peoples, Jane C. Figueiredo, Adetunji T. Toriola, Erin M. Siegel, Christopher I. Li, David Shibata, Kenneth Boucher, June L. Round, Alexis B. Ulrich, Martin Schneider, Lyen C. Huang, Sheetal Hardikar, Cornelia M. Ulrich
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Physical activity and BMI have been individually associated with cancer survivorship but have not yet been studied in combinations in colorectal cancer patients. Here, we investigate individual and combined associations of physica
Externí odkaz:
https://doaj.org/article/f367c0f04c41460f813d8acfd96ef8d1
Autor:
Kaylyn M. Bauer, Morgan C. Nelson, William W. Tang, Tyson R. Chiaro, D. Garrett Brown, Arevik Ghazaryan, Soh-Hyun Lee, Allison M. Weis, Jennifer H. Hill, Kendra A. Klag, Van B. Tran, Jacob W. Thompson, Andrew G. Ramstead, Josh K. Monts, James E. Marvin, Margaret Alexander, Warren P. Voth, W. Zac Stephens, Diane M. Ward, Aaron C. Petrey, June L. Round, Ryan M. O’Connell
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Intercellular communication is critical for homeostasis in mammalian systems, including the gastrointestinal (GI) tract. Exosomes are nanoscale lipid extracellular vesicles that mediate communication between many cell types. Notably, the roles of imm
Externí odkaz:
https://doaj.org/article/28e27534285f41e8b7743abd9a89a3a7