Zobrazeno 1 - 10
of 59
pro vyhledávání: '"June Koo Lee"'
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background The C:G > T:A substitution at the CpG dinucleotide contexts is the most frequent substitution type in genome evolution. The mutational process is obviously ongoing in the human germline; however, its impact on common and rare geno
Externí odkaz:
https://doaj.org/article/58342cf4385b481581c51064dd1d4f53
Autor:
Lixing Yang, Su Wang, Jake June-Koo Lee, Semin Lee, Eunjung Lee, Eve Shinbrot, David A. Wheeler, Raju Kucherlapati, Peter J. Park
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background The classical genetic model of colorectal cancer presents APC mutations as the earliest genomic alterations, followed by KRAS and TP53 mutations. However, the timing and relative order of clonal expansion and other types of genomi
Externí odkaz:
https://doaj.org/article/e1103dd842d241ac93334d046b63241a
Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway
Autor:
Jian Carrot-Zhang, Xiaotong Yao, Siddhartha Devarakonda, Aditya Deshpande, Jeffrey S. Damrauer, Tiago Chedraoui Silva, Christopher K. Wong, Hyo Young Choi, Ina Felau, A. Gordon Robertson, Mauro A.A. Castro, Lisui Bao, Esther Rheinbay, Eric Minwei Liu, Tuan Trieu, David Haan, Christina Yau, Toshinori Hinoue, Yuexin Liu, Ofer Shapira, Kiran Kumar, Karen L. Mungall, Hailei Zhang, Jake June-Koo Lee, Ashton Berger, Galen F. Gao, Binyamin Zhitomirsky, Wen-Wei Liang, Meng Zhou, Sitapriya Moorthi, Alice H. Berger, Eric A. Collisson, Michael C. Zody, Li Ding, Andrew D. Cherniack, Gad Getz, Olivier Elemento, Christopher C. Benz, Josh Stuart, J.C. Zenklusen, Rameen Beroukhim, Jason C. Chang, Joshua D. Campbell, D. Neil Hayes, Lixing Yang, Peter W. Laird, John N. Weinstein, David J. Kwiatkowski, Ming S. Tsao, William D. Travis, Ekta Khurana, Benjamin P. Berman, Katherine A. Hoadley, Nicolas Robine, Matthew Meyerson, Ramaswamy Govindan, Marcin Imielinski
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108784- (2021)
Externí odkaz:
https://doaj.org/article/4264da604a8b4596a7e8b99d914ad26d
Autor:
Jake June-Koo Lee, Youngsook Lucy Jung, Taek-Chin Cheong, Jose Espejo Valle-Inclan, Chong Chu, Doga C. Gulhan, Viktor Ljungström, Hu Jin, Vinayak V. Viswanadham, Emma V. Watson, Isidro Cortés-Ciriano, Stephen J. Elledge, Roberto Chiarle, David Pellman, Peter J. Park
Publikováno v:
Nature.
Focal copy-number amplification is an oncogenic event. Although recent studies have revealed the complex structure1–3 and the evolutionary trajectories4 of oncogene amplicons, their origin remains poorly understood. Here we show that focal amplific
Autor:
Jin Soo Lee, June Koo Lee, H.-G. Jung, Jin Hee Kim, Kyong-Ah Yoon, Yang-Kyu Choi, Sun-Young Kong, Kieun Bae, Young Seok Ju, Sunshin Kim, Geon Kook Lee, Yun-Hee Kim
Publikováno v:
British Journal of Cancer
Background Recently, fusion variants of the breast cancer anti-oestrogen-resistance 4 (BCAR4) gene were recurrently discovered in lung adenocarcinoma from the genome-wide studies. However, the functional characterisation of BCAR4 fusion has not been
Autor:
Isidro, Cortés-Ciriano, Doga C, Gulhan, Jake June-Koo, Lee, Giorgio E M, Melloni, Peter J, Park
Publikováno v:
Nature reviews. Genetics. 23(5)
Distilling biologically meaningful information from cancer genome sequencing data requires comprehensive identification of somatic alterations using rigorous computational methods. As the amount and complexity of sequencing data have increased, so ha
Autor:
Raju Kucherlapati, Peter J. Park, June Koo Lee, Semin Lee, Lixing Yang, Su Wang, Eunjung Lee, David A. Wheeler, Eve Shinbrot
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-17 (2019)
Genome Biology
Genome Biology
Background The classical genetic model of colorectal cancer presents APC mutations as the earliest genomic alterations, followed by KRAS and TP53 mutations. However, the timing and relative order of clonal expansion and other types of genomic alterat
Publikováno v:
Nature Genetics. 51:912-919
Mutations in BRCA1 and/or BRCA2 (BRCA1/2) are the most common indication of deficiency in the homologous recombination (HR) DNA repair pathway. However, recent genome-wide analyses have shown that the same pattern of mutations found in BRCA1/2-mutant
Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway
Autor:
Ina Felau, Reanne Bowlby, Kiran Kumar, June Koo Lee, Zhining Wang, Pavana Anur, Yuexin Liu, Wen-Wei Liang, Jennifer Shelton, Josh Stuart, Christopher C. Benz, Iman Hajirasouliha, Jean C. Zenklusen, Christina Yau, David I. Heiman, David Haan, Tiago C. Silva, Ekta Khurana, Samantha J. Caesar-Johnson, Lixing Yang, Rehan Akbani, Andrew D. Cherniack, John N. Weinstein, Hailei Zhang, Rameen Beroukhim, Ming-Sound Tsao, Toshinori Hinoue, Jeffrey S. Damrauer, Brian Craft, Steven J.M. Jones, Peter W. Laird, Jingchun Zhu, John A. Demchok, Martin L. Ferguson, Aditya Deshpande, Alice H. Berger, Li Ding, Hui Shen, David J. Kwiatkowski, Katherine A. Hoadley, William D. Travis, Xiaotong Yao, Jian Carrot-Zhang, Joshua D. Campbell, Camir Ricketts, Minita Shah, Marcin Imielinski, Olivier Elemento, Ashton C. Berger, Meng Zhou, Sitapriya Moorthi, Nicolas Robine, A. Gordon Robertson, Karen Mungall, Verena Friedl, Siddhartha Devarakonda, Benjamin J. Raphael, Mary Goldman, Esther Rheinbay, Ofer Shapira, Galen F. Gao, Benjamin P. Berman, Eric Minwei Liu, Mauro A. A. Castro, Matthew Meyerson, Tuan Trieu, Lisui Bao, Liming Yang, Christopher K. Wong, Michael C. Zody, Paul T. Spellman, Gad Getz, Roy Tarnuzzer, Kami E. Chiotti, Hyo Young Choi, Anab Kemal, Eric A. Collisson, Kanika Arora, Ramaswamy Govindan, Binyamin Zhitomirsky, Jason C. Chang, D. Neil Hayes
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108784-(2021)
Cell reports
Cell reports
SUMMARY RTK/RAS/RAF pathway alterations (RPAs) are a hallmark of lung adenocarcinoma (LUAD). In this study, we use whole-genome sequencing (WGS) of 85 cases found to be RPA(–) by previous studies from The Cancer Genome Atlas (TCGA) to characterize
Autor:
Elazer R. Edelman, David Gonzalez-Sanchez, Yutaro Mori, Diana Tamayo, Maria S Chancay, Xiaoming Sun, Xiaoyan Xiao, Marian Kalocsay, June Koo Lee, Kyle W. McCracken, Dario R. Lemos, Takaharu Ichimura, Ana C Figueroa-Ramirez, Li Li, Pierre Galichon, M. Todd Valerius, Joseph V. Bonventre, Nathan Lee
Recent studies demonstrated that metabolic disturbance, such as augmented glycolysis, contributes to fibrosis. The molecular regulation of this metabolic perturbation in fibrosis, however, has been elusive. COUP-TFII (also known as NR2F2) is an impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::151270468a1cc926ea7d295f6216098a
https://doi.org/10.1101/2020.06.05.135889
https://doi.org/10.1101/2020.06.05.135889