Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Junchao Qin"'
Autor:
Jing Wang, Yingying Yin, Lei Yang, Junchao Qin, Zixiang Wang, Chunhong Qiu, Yuan Gao, Gang Lu, Fei Gao, Zi-Jiang Chen, Xiyu Zhang, Hongbin Liu, Zhaojian Liu
Publikováno v:
eLife, Vol 13 (2024)
Transmembrane channel-like (TMC) proteins are a highly conserved ion channel family consisting of eight members (TMC1–TMC8) in mammals. TMC1/2 are components of the mechanotransduction channel in hair cells, and mutations of TMC1/2 cause deafness i
Externí odkaz:
https://doaj.org/article/2988ec83d11844a597eef4f541688ec4
Autor:
Shiyu Wang, Yuling Cai, Tongtong Li, Yan Wang, Ziyou Bao, Renxue Wang, Junchao Qin, Ziqi Wang, Yining Liu, Zhaojian Liu, Wai‐Yee Chan, Xiangfeng Chen, Gang Lu, Zi‐Jiang Chen, Tao Huang, Hongbin Liu
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract The progression of spermatogenesis along specific developmental trajectories depends on the coordinated regulation of pre‐mRNA alternative splicing (AS) at the post‐transcriptional level. However, the fundamental mechanism of AS in sperm
Externí odkaz:
https://doaj.org/article/580dd51ab47e4e0b925cda24115a03f0
Autor:
Donghai Cui, Zixiang Wang, Qianli Dang, Jing Wang, Junchao Qin, Jianping Song, Xiangyu Zhai, Yachao Zhou, Ling Zhao, Gang Lu, Hongbin Liu, Gang Liu, Runping Liu, Changshun Shao, Xiyu Zhang, Zhaojian Liu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Regulation of alternative splicing (AS) enables a single transcript to yield multiple isoforms that increase transcriptome and proteome diversity. Here, we report that spliceosome component Usp39 plays a role in the regulation of hepatocyte
Externí odkaz:
https://doaj.org/article/b67b2955615d443aa044fde249134601
Autor:
Zixiang Wang, Shourong Wang, Junchao Qin, Xiyu Zhang, Gang Lu, Hongbin Liu, Haiyang Guo, Ligang Wu, Victoria O. Shender, Changshun Shao, Beihua Kong, Zhaojian Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Altered expression of splicing factors can contribute to tumour progression. Here the authors show that splicing factor BUD31 enhances ovarian cancer progression by promoting exon inclusion in the anti-apoptotic BCL2 family member, BCL2L12.
Externí odkaz:
https://doaj.org/article/ecc4c07d0bba40c28fd1c9e0b5d35895
Autor:
Junchao Qin, Tao Huang, Jing Wang, Limei Xu, Qianli Dang, Xiuhua Xu, Hongbin Liu, Zhaojian Liu, Changshun Shao, Xiyu Zhang
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-9 (2022)
Abstract The recombinase RAD51 catalyzes the DNA strand exchange reaction in homologous recombination (HR) during both mitosis and meiosis. However, the physiological role of RAD51 during spermatogenesis remains unclear since RAD51 null mutation is e
Externí odkaz:
https://doaj.org/article/2ab31572ea9e4b97a80b0ce2248bea53
Autor:
Jianping Song, Donghai Cui, Jing Wang, Junchao Qin, Shourong Wang, Zixiang Wang, Xiangyu Zhai, Huan Ma, Delin Ma, Yanfeng Liu, Bin Jin, Zhaojian Liu
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Cholangiocarcinomas (CCAs) are rare but aggressive tumors of the bile ducts. CCAs are often diagnosed at an advanced stage and respond poorly to current conventional radiotherapy and chemotherapy. High mobility group A1 (HMGA1) is an archite
Externí odkaz:
https://doaj.org/article/c620c10c50de4ae7a211a56ca0070ae8
Autor:
Shourong Wang, Zixiang Wang, Jieyin Li, Junchao Qin, Jianping Song, Yingwei Li, Ling Zhao, Xiyu Zhang, Haiyang Guo, Changshun Shao, Beihua Kong, Zhaojian Liu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-18 (2021)
Abstract Aberrant expression of splicing factors was found to promote tumorigenesis and the development of human malignant tumors. Nevertheless, the underlying mechanisms and functional relevance remain elusive. We here show that USP39, a component o
Externí odkaz:
https://doaj.org/article/953d4fe21bc8497f8b3f3d99d93793bc
Autor:
Limei Xu, Tingting Wu, Shihua Lu, Xiaohe Hao, Junchao Qin, Jing Wang, Xiyu Zhang, Qiao Liu, Beihua Kong, Yaoqin Gong, Zhaojian Liu, Changshun Shao
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101604- (2020)
Ovarian cancer is the most lethal gynecological malignancy. Abnormal homologous recombination repair, high level of reactive oxygen species (ROS) and upregulation of antioxidant genes are characteristic features of ovarian cancer. However, the molecu
Externí odkaz:
https://doaj.org/article/5b50b962dc954c91b54c2a7b09e9c176
Autor:
Junchao Qin, Tao Huang, Zixiang Wang, Xiyu Zhang, Jing Wang, Qianli Dang, Donghai Cui, Xinyu Wang, Yunjiao Zhai, Ling Zhao, Gang Lu, Changshun Shao, Shiyang Li, Hongbin Liu, Zhaojian Liu
Publikováno v:
Cell Death & Differentiation. 30:184-194
Alternative splicing (AS) is tightly regulated during cell differentiation and development. AS events are prevalent in the testis, but the splicing regulation in spermatogenesis remains unclear. Here we report that the spliceosome component Bud31 pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cca5339fb29c1b2f52076d0f722d62
https://doi.org/10.1038/s41418-022-01057-1
https://doi.org/10.1038/s41418-022-01057-1
Autor:
Donghai Cui, Zixiang Wang, Qianli Dang, Jing Wang, Junchao Qin, Jianping Song, Xiangyu Zhai, Ling Zhao, Gang Lu, Hongbin Liu, Runping Liu, Changshun Shao, Xiyu Zhang, Zhaojian Liu
Regulation of alternative splicing (AS) enables a single transcript to yield multiple isoforms that increase transcriptome and proteome diversity. Here, we report that spliceosome component Usp39 plays a critical role in the regulation of hepatocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d0d0ca50a3e97408b125a769e31767
https://doi.org/10.21203/rs.3.rs-2182223/v1
https://doi.org/10.21203/rs.3.rs-2182223/v1
