Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Junchao, Tong"'
Autor:
Anton Lindberg, Emily Murrell, Junchao Tong, N. Scott Mason, Daniel Sohn, Johan Sandell, Peter Ström, Jeffrey S. Stehouwer, Brian J. Lopresti, Jenny Viklund, Samuel Svensson, Chester A. Mathis, Neil Vasdev
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Positron emission tomography (PET) imaging of tau aggregation in Alzheimer’s disease (AD) is helping to map and quantify the in vivo progression of AD pathology. To date, no high-affinity tau-PET radiopharmaceutical has been optimized for
Externí odkaz:
https://doaj.org/article/565281a593e843aeae917584e9015b15
Autor:
Sarah E. Watling, Talwinder Gill, Erin V. Gaudette, J. Don Richardson, Tina McCluskey, Junchao Tong, Jeffrey H. Meyer, Jerry Warsh, Rakesh Jetly, Michael G. Hutchison, Shawn G. Rhind, Sylvain Houle, Stephen J. Kish, Isabelle Boileau
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Microglia are immune brain cells implicated in stress-related mental illnesses including posttraumatic stress disorder (PTSD). Their role in the pathophysiology of PTSD, and on neurobiological systems that regulate stress, is not completely
Externí odkaz:
https://doaj.org/article/2e26b60e876e435592d38a1c1f49ac1f
Autor:
Sarah E. Watling, Shawn G. Rhind, Jerry Warsh, Duncan Green, Tina McCluskey, Junchao Tong, Peter Truong, Sofia Chavez, J. Don Richardson, Stephen J. Kish, Isabelle Boileau
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionOxidative stress has been implicated in psychiatric disorders, including posttraumatic stress disorder (PTSD). Currently, the status of glutathione (GSH), the brain's most abundant antioxidant, in PTSD remains uncertain. Therefore, the cu
Externí odkaz:
https://doaj.org/article/032ec1a37d7e44e8b393dd6b8b860649
Autor:
Kimberly L. Desmond, Anton Lindberg, Armando Garcia, Junchao Tong, Michael B. Harkness, Elena Dobrota, Kelly Smart, Carme Uribe, Jeffrey H. Meyer, Sylvain Houle, Antonio P. Strafella, Songye Li, Yiyun Huang, Neil Vasdev
Publikováno v:
Molecular Imaging, Vol 2023 (2023)
[18F]SynVesT-1 is a PET radiopharmaceutical that binds to the synaptic vesicle protein 2A (SV2A) and serves as a biomarker of synaptic density with widespread clinical research applications in psychiatry and neurodegeneration. The initial goal of thi
Externí odkaz:
https://doaj.org/article/ae6f880542624361ace3956843c9ef59
Autor:
Sarah E. Watling, Samantha Jagasar, Tina McCluskey, Jerry Warsh, Shawn G. Rhind, Peter Truong, Sofia Chavez, Sylvain Houle, Junchao Tong, Stephen J. Kish, Isabelle Boileau
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2023)
IntroductionPreclinical data suggest methamphetamine (MA), a widely used stimulant drug, can harm the brain by causing oxidative stress and inflammation, but only limited information is available in humans. We tested the hypothesis that levels of glu
Externí odkaz:
https://doaj.org/article/a94226a0a77240f090977fce36b2b74d
Autor:
Nadia Boachie, Erin Gaudette, Richard P. Bazinet, Lin Lin, Rachel F. Tyndale, Esmaeil Mansouri, Marilyn A. Huestis, Junchao Tong, Bernard Le Foll, Stephen J. Kish, Tony P. George, Isabelle Boileau
Publikováno v:
Brain Sciences, Vol 13, Iss 10, p 1375 (2023)
Background: Endocannabinoids and related N-acylethanolamines (NAEs) are bioactive lipids with important physiological functions and putative roles in mental health and addictions. Although chronic cannabis use is associated with endocannabinoid syste
Externí odkaz:
https://doaj.org/article/c15397b4384f4b5dbc0cffdffb8ba890
Autor:
Vidya Narayanaswami, Junchao Tong, Ferdinando Fiorino, Beatrice Severino, Rosa Sparaco, Elisa Magli, Flavia Giordano, Peter M. Bloomfield, Jaya Prabhakaran, J. John Mann, Neil Vasdev, Kenneth Dahl, J. S. Dileep Kumar
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-17 (2020)
Abstract Background Serotonin 1A (5-HT1A) receptors are implicated in the pathogenesis of several psychiatric and neurodegenerative disorders motivating the development of suitable radiotracers for in vivo positron emission tomography (PET) neuroimag
Externí odkaz:
https://doaj.org/article/d04212c45a1c477c855f4b83967b0456
Autor:
Amanda J. Boyle, Emily Murrell, Junchao Tong, Christin Schifani, Andrea Narvaez, Melinda Wuest, Frederick West, Frank Wuest, Neil Vasdev
Publikováno v:
Molecules, Vol 27, Iss 23, p 8529 (2022)
Fluorine-18 labeled 6-fluoro-6-deoxy-D-fructose (6-[18F]FDF) targets the fructose-preferred facilitative hexose transporter GLUT5, which is expressed predominantly in brain microglia and activated in response to inflammatory stimuli. We hypothesize t
Externí odkaz:
https://doaj.org/article/d531225683494a0aba71ae3076373717
Autor:
Pablo M Rusjan, Dunja Knezevic, Isabelle Boileau, Junchao Tong, Romina Mizrahi, Alan A Wilson, Sylvain Houle
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192410 (2018)
[11C]CURB is a novel irreversible radioligand for imaging fatty acid amide hydrolase in the human brain. In the present work, we validate an algorithm for generating parametric map images of [11C]CURB acquired with a high resolution research tomograp
Externí odkaz:
https://doaj.org/article/a91f47903a02448a8440f4f811e003a7
Repurposing [11C]MC1 for PET Imaging of Cyclooxygenase-2 in Colorectal Cancer Xenograft Mouse Models
Autor:
Junchao Tong, Amanda J. Boyle, Victor W. Pike, Sami S. Zoghbi, Neil Vasdev, Andrea Narvaez, Robert B. Innis
Publikováno v:
Molecular Imaging and Biology. 24:365-370
Cyclooxygenase-2 (COX-2) is a target for inflammation and colorectal cancer (CRC). This study evaluated the COX-2 neuro-PET radiopharmaceutical, [11C]MC1, in CRC xenograft mice. [11C]MC1 was evaluated in ICRscid mice with HT-29 and HCT-116 CRC xenogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e70c4dec79aa410476e47f1672c287a
https://doi.org/10.1007/s11307-021-01675-0
https://doi.org/10.1007/s11307-021-01675-0