Cxcr2 signaling and the microbiome suppress inflammation, bile duct injury, and the phenotype of experimental biliary atresia.

Autor: Junbae Jee, Reena Mourya, Pranavkumar Shivakumar, Lin Fei, Michael Wagner, Jorge A Bezerra

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182089 (2017)

Biliary atresia is progressive fibro-inflammatory cholangiopathy of young children. Central to pathogenic mechanisms of injury is the tissue targeting by the innate and adaptive immune cells. Among these cells, neutrophils and the IL-8/Cxcl-8 signali

Externí odkaz: https://doaj.org/article/e4441947fa45492a9aa69745227c00a8

Maternal regulation of biliary disease in neonates via gut microbial metabolites

Autor: Jai Junbae Jee, Li Yang, Pranavkumar Shivakumar, Pei-pei Xu, Reena Mourya, Unmesha Thanekar, Pu Yu, Yu Zhu, Yongkang Pan, Haibin Wang, Xufei Duan, Yongqin Ye, Bin Wang, Zhu Jin, Yuanmei Liu, Zhiqing Cao, Miki Watanabe-Chailland, Lindsey E. Romick-Rosendale, Michael Wagner, Lin Fei, Zhenhua Luo, Nicholas J. Ollberding, Shao-tao Tang, Jorge A. Bezerra

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

The pathogenesis of biliary atresia remains poorly understood. Here, the authors report that maternal butyrate treatment alters the gut microbiome and glutamine/hypoxanthine metabolites similar to human subjects, and suppresses biliary atresia in new

Externí odkaz: https://doaj.org/article/f8ba779a49e84d54b38c7a365e7df194

Cxcr2 signaling and the microbiome suppress inflammation, bile duct injury, and the phenotype of experimental biliary atresia

Autor: Michael Wagner, Pranavkumar Shivakumar, Jorge A. Bezerra, Lin Fei, Junbae Jee, Reena Mourya

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182089 (2017)
PLoS ONE

Biliary atresia is progressive fibro-inflammatory cholangiopathy of young children. Central to pathogenic mechanisms of injury is the tissue targeting by the innate and adaptive immune cells. Among these cells, neutrophils and the IL-8/Cxcl-8 signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff62c872793bffa1d3ec268b54c51f6f
http://europepmc.org/articles/PMC5538677?pdf=render

Contributions of Edema Factor and Protective Antigen to the Induction of Protective Immunity by Bacillus anthracis Edema Toxin as an Intranasal Adjuvant

Autor: Stephen H. Leppla, Wei-Jen Tang, Daniel Tomé, Alexandra Duverger, Prosper N. Boyaka, Jeanne-Marie Carré, Junbae Jee, Estelle Cormet-Boyaka

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 185 (10), pp.5943-5952. ⟨10.4049/jimmunol.0902795⟩

We have shown that intranasal coapplication of Bacillus anthracis protective Ag (PA) together with a B. anthracis edema factor (EF) mutant having reduced adenylate cyclase activity (i.e., EF-S414N) enhances anti-PA Ab responses, but also acts as a mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5503c3c86565daf1c387c8628b454f
https://doi.org/10.4049/jimmunol.0902795

Routes of Allergic Sensitization and Myeloid Cell IKK beta Differentially Regulate Antibody Responses and Allergic Airway Inflammation in Male and Female Mice

Autor: Estelle Cormet-Boyaka, Michael J. Fial, Ian C. Davis, Stephanie DiBartola, Junbae Jee, Astrid Bonnegarde-Bernard, Haley Steiner, Daniel Tomé, Prosper N. Boyaka

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (3), pp.e92307. ⟨10.1371/journal.pone.0092307⟩
PLoS ONE, Vol 9, Iss 3, p e92307 (2014)

WOS:000333675600031; International audience; Gender influences the incidence and/or the severity of several diseases and evidence suggests a higher rate of allergy and asthma among women. Most experimental models of allergy use mice sensitized via th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61611d4811b20aea424a18bcb2ad5af9
https://hal-agroparistech.archives-ouvertes.fr/hal-01568631