Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Junaid Afzal"'
Autor:
Du Wenqiang, Ashkan Novin, Yamin Liu, Junaid Afzal, Yasir Suhail, Shaofei Liu, Nicole R. Gavin, Jennifer R. Jorgensen, Christopher M. Morosky, Reinaldo Figueroa, Tannin A. Schmidt, Melinda Sanders, Molly A. Brewer, Kshitiz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Scar tissue formation is a hallmark of wound repair in adults and can chronically affect tissue architecture and function. To understand the general phenomena, we sought to explore scar-driven imbalance in tissue homeostasis caused by a comm
Externí odkaz:
https://doaj.org/article/6a3069e8432b445ebee9af42f33137d5
Autor:
Junaid Afzal, Kshitiz
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/bcaa226b6b904df486b38307b46a4ac5
Autor:
Junaid Afzal, Wenqiang Du, Ashkan Novin, Yamin Liu, Khadija Wali, Anarghya Murthy, Ashley Garen, Gunter Wagner, Kshitiz
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Multiple parallels exist between placentation and cancer dissemination at molecular, cellular, and anatomical levels, presenting placentation as a unique model to mechanistically understand the onset of cancer metastasis. In humans, interaction of pl
Externí odkaz:
https://doaj.org/article/3217ed56d32f4f7cb6175ab5bc26df34
Autor:
Junaid Afzal, Yamin Liu, Wenqiang Du, Yasir Suhail, Pengyu Zong, Jianlin Feng, Visar Ajeti, Wasim A. Sayyad, Joerg Nikolaus, Maya Yankova, Alix C. Deymier, Lixia Yue, Kshitiz
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111146- (2022)
Summary: The vast potential of human induced pluripotent stem-cell-derived cardiomyocytes (hiPSC-CMs) in preclinical models of cardiac pathologies, precision medicine, and drug screening remains to be fully realized because hiPSC-CMs are immature wit
Externí odkaz:
https://doaj.org/article/0dbf0aa911234cc5aa6b863a486822f4
Autor:
Yamin Liu, Amina Atiq, Anna Peterson, Mikayla Moody, Ashkan Novin, Alix C. Deymier, Junaid Afzal, Kshitiz
Publikováno v:
Metabolites, Vol 13, Iss 4, p 549 (2023)
Metabolic acidosis (MA) is a highly prevalent disorder in a significant proportion of the population, resulting from imbalance in blood pH homeostasis. The heart, being an organ with very low regenerative capacity and high metabolic activity, is vuln
Externí odkaz:
https://doaj.org/article/af8d4479930b4eb2b898dd04c2a5b4d5
Publikováno v:
BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background The disease burden of SARS-CoV-2 as measured by tests from various localities, and at different time points present varying estimates of infection and fatality rates. Models based on these acquired data may suffer from systematic
Externí odkaz:
https://doaj.org/article/3159fa55c9a84bb18192020eb78c72d7
Autor:
Yamin Liu, Junaid Afzal, Styliani Vakrou, Gabriela V. Greenland, C. Conover Talbot, Virginia B. Hebl, Yufan Guan, Rehan Karmali, Jil C. Tardiff, Leslie A. Leinwand, Jeffrey E. Olgin, Samarjit Das, Ryuya Fukunaga, M. Roselle Abraham
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
Background: Hypertrophic cardiomyopathy (HCM) is characterized by myocyte hypertrophy and fibrosis. Studies in two mouse models (R92W-TnT/R403Q-MyHC) at early HCM stage revealed upregulation of endothelin (ET1) signaling in both mutants, but TGFβ si
Externí odkaz:
https://doaj.org/article/f0f284719e3944509201f2ec8335d642
Autor:
Hemanth N. Banavath, Barbara Roman, Nathan Mackowski, Debjit Biswas, Junaid Afzal, Yohei Nomura, Soroosh Solhjoo, Brian O'Rourke, Mark Kohr, Elizabeth Murphy, Charles Steenbergen, Samarjit Das
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 24 (2019)
Background Translocation of miR‐181c into cardiac mitochondria downregulates the mitochondrial gene, mt‐COX1. miR‐181c/d−/− hearts experience less oxidative stress during ischemia/reperfusion (I/R) and are protected against I/R injury. Addi
Externí odkaz:
https://doaj.org/article/e7018645c9104239a99e6920ae4b21b1
Autor:
Junaid Afzal, MBBS, MS, Angel Chan, MD PhD, Mehmet Fatih Karakas, MD, Kirubel Woldemichael, BS, Styliani Vakrou, MD, Yufan Guan, MD, Jeffrey Rathmell, PhD, Richard Wahl, MD, Martin Pomper, MD, PhD, D. Brian Foster, PhD, Miguel A. Aon, PhD, Benjamin Tsui, PhD, Brian O’Rourke, PhD, M. Roselle Abraham, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 5, Pp 543-560 (2017)
Adult stem cells demonstrate metabolic flexibility that is regulated by cell adhesion status. The authors demonstrate that adherent cells primarily utilize glycolysis, whereas suspended cells rely on oxidative phosphorylation for their ATP needs. Akt
Externí odkaz:
https://doaj.org/article/f7e9e7dda3dc4926bc72f4305223c445
Autor:
Xiaoping Lin, Steven Steinberg, Suresh K Kandasamy, Junaid Afzal, Blaid Mbiyangandu, Susan E Liao, Yufan Guan, Celia P Corona-Villalobos, Scot J Matkovich, Neal Epstein, Dotti Tripodi, Zhaoxia Huo, Garry Cutting, Theodore P Abraham, Ryuya Fukunaga, M Roselle Abraham
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156065 (2016)
MicroRNAs (miRNAs) are recognized as important regulators of cardiac development, hypertrophy and fibrosis. Recent studies have demonstrated that genetic variations which cause alterations in miRNA:target interactions can lead to disease. We hypothes
Externí odkaz:
https://doaj.org/article/3083cf18fae34166813dbd5d0f4f83d3