Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Jun-ichiro Oka"'
Autor:
Junpei Takahashi, Yudai Ueta, Daisuke Yamada, Sachie Sasaki‐Hamada, Takashi Iwai, Tomomi Akita, Chikamasa Yamashita, Akiyoshi Saitoh, Jun‐Ichiro Oka
Publikováno v:
Neuropsychopharmacology Reports, Vol 42, Iss 4, Pp 492-501 (2022)
Abstract Aim We previously reported that oxytocin, a peptide hormone, can reverse the β‐amyloid peptide (25–35) (Aβ25–35)‐induced impairments of the murine hippocampal synaptic plasticity. In this study, we examined the effects of oxytocin
Externí odkaz:
https://doaj.org/article/ff4dd2c485744413a1596cf3f380bc36
Autor:
Azusa Sugiyama, Misa Yamada, Hiroki Furuie, Leo Gotoh, Akiyoshi Saitoh, Hiroshi Nagase, Jun-Ichiro Oka, Mitsuhiko Yamada
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 3, Pp 174-179 (2019)
Strategies to facilitate extinction of fear memory have attracted increasing attention for enhancing the effectiveness of exposure therapy for anxiety disorders. Previously, we demonstrated that systemic administration of a delta opioid receptor agon
Externí odkaz:
https://doaj.org/article/95d6dffb1d39407593d60fb4a09fe3ae
Autor:
Akiyoshi Saitoh, Akinobu Soda, Shuhei Kayashima, Kazumi Yoshizawa, Jun-Ichiro Oka, Hiroshi Nagase, Mitsuhiko Yamada
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 3, Pp 176-183 (2018)
We previously reported that systemic administration of a delta opioid receptor (DOP) agonist, KNT-127, produced a potent anxiolytic-like effect in rats. Interestingly, DOPs are highly distributed in the prelimbic medial prefrontal cortex (PL-PFC). In
Externí odkaz:
https://doaj.org/article/e2e5275ac36d4120ba0daf7bb970fb18
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 3, Pp 134-137 (2017)
Chotosan (CTS), a traditional herbal formula called Kampo medicine, was shown to be effective in the treatment of vascular dementia in a clinical study, and exerted protective effects against transient cerebral ischemia-induced cognitive impairment i
Externí odkaz:
https://doaj.org/article/7344c1f8f5c94e8ea9539eb14e7183fd
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 2, Pp 110-113 (2017)
We previously demonstrated that chotosan (CTS), a traditional herbal formula called Kampo medicine, improves diabetes-induced cognitive deficits. In the present study, we investigated the antidepressant-like effects of CTS in mice. The administration
Externí odkaz:
https://doaj.org/article/2c7c94047af148d580cbb178294ac4ba
Autor:
Sachie Sasaki-Hamada, Keita Tamaki, Hayuma Otsuka, Tatsuto Ueno, Hiroaki Sacai, Yimin Niu, Kinzo Matsumoto, Jun-Ichiro Oka
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 2, Pp 192-200 (2014)
Childhood-onset type 1 diabetes is associated with modest impairments in cognition and has an elevated risk of cognitive decline. Our previous study showed that working memory and hippocampal long-term depression (LTD) were impaired in juvenile-onset
Externí odkaz:
https://doaj.org/article/961d14dbb0124ae696254373b74d7088
Autor:
Kinzo Matsumoto, Qi Zhao, Yimin Niu, Hironori Fujiwara, Ken Tanaka, Sachie Sasaki-Hamada, Jun-Ichiro Oka
Publikováno v:
Journal of Pharmacological Sciences, Vol 122, Iss 4, Pp 257-269 (2013)
Cognitive deficits and behavioral and psychological symptoms of dementia (BPSD) are typical features of patients with dementia such as Alzheimer’s disease (AD), vascular dementia (VD), and other forms of senile dementia. Clinical evidence has demon
Externí odkaz:
https://doaj.org/article/15316cda8e924b4db98b0148337d05de
Autor:
Sachie Sasaki-Hamada, Hiroaki Sacai, Azusa Sugiyama, Takahiro Iijima, Akiyoshi Saitoh, Masatoshi Inagaki, Mitsuhiko Yamada, Jun-Ichiro Oka
Publikováno v:
Journal of Pharmacological Sciences, Vol 122, Iss 3, Pp 232-236 (2013)
We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In th
Externí odkaz:
https://doaj.org/article/208703f545a54db8a168d1261b893813
Publikováno v:
Journal of Pharmacological Sciences, Vol 107, Iss 2, Pp 226-230 (2008)
Tamoxifen (Tam) decreased the clearance of L-glutamate (L-Glu) by cultured astrocytes at 1 pM, 1 nM, and 1 μM, but became toxic at 10 μM. When L-Glu transporters were mostly inhibited by threo-β-benzyloxyaspartate (TBOA) (1 mM) or D,L-threo-β-hyd
Externí odkaz:
https://doaj.org/article/b614048c91f44446b8c1c7111d981d97
Publikováno v:
Journal of Pharmacological Sciences, Vol 94, Iss 2, Pp 137-143 (2004)
The novel antiepileptic drug gabapentin was designed as a structural analog of γ-aminobutyric acid (GABA). However, its mechanism of action remains unclear. In the present study, we investigated the effect of gabapentin on spinal reflexes in anesthe
Externí odkaz:
https://doaj.org/article/dcc778a2973a4906b7f5881948ee4491