Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jun-ichi Sudo"'
Autor:
Jun-ichi Sudo, Fumiji Miyasaka, Kimio Higashiyama, Takashi Meguro, Kozo Takayama, Hiroaki Iwase, Katsuhiko Kakuno
Publikováno v:
Drug Development and Industrial Pharmacy. 28:59-65
To increase delivery of L-dopa in its transdermal absorption, a new lipophilic derivative of L-dopa, L-dopa-butylester, was synthesized. An in-vitro study employing two-chamber diffusion cells, in which the excised rat abdominal skin was mounted, rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae11083de05190577f6ade8f0191eca
https://doi.org/10.1081/ddc-120001486
https://doi.org/10.1081/ddc-120001486
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 744:19-23
An HPLC assay for determination of ATPase activity was developed and validated. After stopping the enzyme reaction of the enzyme source (rat renal cortical basolateral membranes) with ATP, products derived from ATP were analyzed by two methods; HPLC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1486b9da9105237499f56503dfdd0054
https://doi.org/10.1016/s0378-4347(00)00218-8
https://doi.org/10.1016/s0378-4347(00)00218-8
Autor:
Jun-ichi Sudo, Jun Terui, Tsuneji Nagai, Hiroaki Iwase, Kozo Takayama, Takiko Watanabe, Katsuhiko Kakuno
Publikováno v:
Drug Development and Industrial Pharmacy. 26:755-759
To maintain the stability of L-dopa in hydrogel, a new system composed of two separate layers of L-dopa and hydrogel was developed. L-Dopa sheets were made by immersing L-dopa solution into wiper sheets and by lyophilizing them. Examination for stabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95382bee8aabbd0c999c6063bf8ac50
https://doi.org/10.1081/ddc-100101294
https://doi.org/10.1081/ddc-100101294
Autor:
Kyoko Kon, Motoki Yonekawa, Kazutaka Kukita, Toshio Higa, Jun-ichi Sudo, Akio Kawamura, Jun Terui, Tadamasa Kon
Publikováno v:
Clinical and Experimental Nephrology. 3:23-28
Background. Desferrioxamine (DFO) a chelating agent, is used to treat metal toxicity caused by iron and aluminum in patients on hemodialysis. We hypothesized that DFO could also be used to treat cadrium-induced nephropathy. Animal experiments were th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7823b70ed04c254069569dd83092fdac
https://doi.org/10.1007/s101570050004
https://doi.org/10.1007/s101570050004
Autor:
Jun-ichi Sudo, Kozo Takayama, Jun Terui, Momoko Soyama, Katsuhiko Kakuno, Tsuneji Nagai, Hiroaki Iwase
Publikováno v:
European Journal of Pharmaceutical Sciences. 7:67-71
To improve compliance in administration of l-dopa, transdermal absorption of the agent was investigated in rats in vitro employing two-chamber diffusion cells in which the excised rat abdominal skin was mounted, and in vivo using an alcoholic hydroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61692509bee58bdc89aaecaca1dcb98
https://doi.org/10.1016/s0928-0987(98)00007-4
https://doi.org/10.1016/s0928-0987(98)00007-4
Publikováno v:
European Journal of Pharmacology: Environmental Toxicology and Pharmacology. 270:229-235
To explore the kinetics of Cd2+ in the body, rats received a single intravenous injection of CdCl2 or Cd-saturated metallothionein-II at 0.3 mg Cd/kg body weight. Cd2+ in the two agents was biexponentially eliminated from plasma: rapidly in the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99593a4ef17fa910c07ca90a9ee9abf
https://doi.org/10.1016/0926-6917(94)90067-1
https://doi.org/10.1016/0926-6917(94)90067-1
Autor:
Jun-ichi Sudo, Taiji Hayashi
Publikováno v:
The Journal of Toxicological Sciences. 17:31-39
To comparably investigate hemotoxic potentials of CdCl2, cadmium-saturated metallothioneins-I (Cd-MT-I) and -II (Cd-MT-II), rats received single intravenous injections of one of those dissolved in saline with equivalent concentrations of Cd (0, 0.1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695b04e55bcc09ba6b3364bdf62a5d53
https://doi.org/10.2131/jts.17.31
https://doi.org/10.2131/jts.17.31
Autor:
Yoshihiro SUZUKI, Jun-ichi SUDO
Publikováno v:
Japanese Journal of Pharmacology. 52:233-244
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e28c190583ba949f5e95d9f58c7a6436
https://doi.org/10.1016/s0021-5198(19)40058-9
https://doi.org/10.1016/s0021-5198(19)40058-9
Autor:
Nobuhiko Yamazaki, Tomizo Okuyama, Jun-ichi Sudo, Tsuneyoshi Tanabe, Tohru Kaku, Takashi Kubota, Yoshio Monma
Publikováno v:
The Journal of Toxicological Sciences. 15:1-13
Employing propranolol as a non-selective beta-blocker, atenolol, acebutolol and metoprolol as selective beta 1-blockers, butoxamine as a selective beta 2-blocker, labetalol as an alpha- and beta-blocker, and phentolamine as an alpha-blocker, we compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcca921084e347df9a6240645e57562
https://doi.org/10.2131/jts.15.1
https://doi.org/10.2131/jts.15.1
Publikováno v:
Biological and Pharmaceutical Bulletin. 17:871-873
To explore the mechanism responsible for puromycin aminonucleoside induced-nephrotoxicity, metal content was preliminarily investigated in the kidneys of rats that had received a single subcutaneous injection of the agent (80 mg/kg body weight). In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36c08b66fdee3479efdbbef085d6cfe
https://doi.org/10.1248/bpb.17.871
https://doi.org/10.1248/bpb.17.871